Association between obesity indicators and hyperuricemia in Chinese adults / 公共卫生与预防医学

Objective The study aims to find a suitable obesity index for predicting hyperuricemia (HUA)in Chinese adults. Methods The obesity indexes of 8133 subjects in China Health and Nutrition Survey in 2009 were calculated, and the basic situation of them was analyzed descriptively. χ2 test and t test were used to test the differences of categorical variables and continuous variables between the HUA group and the non-HUA group. The area under the curve (AUC) and receiver operating characteristic (ROC) curves were used to analyze the predictive value of these indices for HUA. Binary logistic regression was used to analyze the relationship between obesity and HUA. Results Demographic covariates, prevalence and Body Mass Index (BMI) all have impacts on the prevalence of HUA. Obesity indexes have a good predictive effect on HUA, and the Lipid Accumulation Product (LAP) is the best (AUC=0.77 (95% CI [0.75, 0.78]). Obesity indexes all have a significant correlation with HUA. When covariates were not adjusted, LAP had the highest OR value (OR=5.87, 95% CI [5.08, 6.77]). Conclusion LAP index is significantly related to HUA, and it can be used as an emerging index to assess the prevalence of HUA in Chinese adults.

Comparison of the predictive value of anthropometric indicators for the risk of benign prostatic hyperplasia in southern China / 亚洲男科学杂志(英文版)

This study aimed to compare the predictive value of six selected anthropometric indicators for benign prostatic hyperplasia (BPH). Males over 50 years of age who underwent health examinations at the Health Management Center of the Second Xiangya Hospital, Central South University (Changsha, China) from June to December 2020 were enrolled in this study. The characteristic data were collected, including basic anthropometric indices, lipid parameters, six anthropometric indicators, prostate-specific antigen, and total prostate volume. The odds ratios (ORs) with 95% confidence intervals (95% CIs) for all anthropometric parameters and BPH were calculated using binary logistic regression. To assess the diagnostic capability of each indicator for BPH and identify the appropriate cutoff values, receiver operating characteristic (ROC) curves and the related areas under the curves (AUCs) were utilized. All six indicators had diagnostic value for BPH (all P ≤ 0.001). The visceral adiposity index (VAI; AUC: 0.797, 95% CI: 0.759-0.834) had the highest AUC and therefore the highest diagnostic value. This was followed by the cardiometabolic index (CMI; AUC: 0.792, 95% CI: 0.753-0.831), lipid accumulation product (LAP; AUC: 0.766, 95% CI: 0.723-0.809), waist-to-hip ratio (WHR; AUC: 0.660, 95% CI: 0.609-0.712), waist-to-height ratio (WHtR; AUC: 0.639, 95% CI: 0.587-0.691), and body mass index (BMI; AUC: 0.592, 95% CI: 0.540-0.643). The sensitivity of CMI was the highest (92.1%), and WHtR had the highest specificity of 94.1%. CMI consistently showed the highest OR in the binary logistic regression analysis. BMI, WHtR, WHR, VAI, CMI, and LAP all influence the occurrence of BPH in middle-aged and older men (all P ≤ 0.001), and CMI is the best predictor of BPH.

A Study on Dietary Habits and Lifestyle of Girls with Precocious Puberty / 대한소아소화기영양학회지

PURPOSE: This study was conducted to analyze the change in the obesity index in girls receiving a gonadotropin-releasing hormone agonist (GnRHa), based on treatment duration, and to aid in nutritional counseling by investigating dietary habits and lifestyle. METHODS: Anthropometric examinations were conducted on 62 girls treated with GnRHa from January 2010 through July 2014. Parents were asked to fill out questionnaires on patient dietary habits and lifestyle. RESULTS: The group taking GnRHa for over 1 year had a higher rate of obesity increase than the group taking GnRHa for less than 1 year, but they had common habits related to obesity, which should be corrected. In addition, 69.2% of the normal weight group taking GnRHa for over 1 year gained weight, and needed more intensive programs, which include physical exercise and nutritional education. Although girls with precocious puberty showed a decrease in the intake of high-calorie foods with nutritional intervention regardless of treatment duration, they still had problems that needed improvement, such as shorter meals and lack of exercise. CONCLUSION: Girls with precocious puberty and their parents should emphasize maintenance of proper body weight, especially when treatment for over 1 year is anticipated. Consistent education in nutrition, ways to increase intensity and duration of physical activity, and the need to slow down mealtimes are important in managing obesity; doctors need to perform regular checkups and provide nutritional counseling.

Comparison of Correlation between Prostate Volume and Obesity Indices

BACKGROUND: Benign prostatic hyperplasia (BPH) is a common condition in males over 40 years old, and the incidence of BPH has a tendency to increase with age. Obesity is state of excessive accumulation of fat in the body that leads to changes in the body's metabolism and endocrine function. Therefore, progression of BPH occurs in the obese state according to many articles. The purpose of this study was to compare the efficacy of obesity indices which correlate with prostate volume. METHODS: The study was carried out in 285 males, who visited a health promotion center and underwent transrectal ultrasonography and abdominal fat computed tomography from April, 2010 to June, 2013. Anthropometric parameters were measured directly and blood samples were obtained in the morning after over eight hours of fasting. The correlation between obesity indices and prostate volume was analyzed. RESULTS: After adjusting for age, prostate volume was positively correlated with BMI (r=0.227, P<0.001), waist circumference (WC) (r=0.151, P=0.011), waist to height ratio (WHtR) (r=0.149, P=0.012), and visceral fat area (VFA) (r=0.157, P=0.008). However prostate volume showed no correlation with subcutaneous fat area (SFA) and visceral to subcutaneous ratio (VSR). WHtR had the largest area under the curve (AUC) for the identification of prostate volume more than 30 mL (AUC=0.595, P=0.017) followed by VFA and BMI in order. CONCLUSION: Prostate volume was positively correlated with BMI, WC, WHtR, and VFA among the obesity indices and WHtR had the largest AUC followed by VFA and BMI in order.

The Effects of Low-sodium Diet Education Program on Dietary Habits, Diet Quality and Obesity Index in Overweight and Obese Middle-aged Women / 대한지역사회영양학회지

OBJECTIVES: This study was conducted to investigate the effect of low sodium diet education program on dietary habits, diet quality, and measures of obesity in overweight or obese middle-aged women. METHODS: Subjects were 81 individuals aged 45 years or over, who completed an 8-week nutrition education. The subjects were divided into a normal group (N = 30) and an overweight-obese group (N = 51) according to the BMI. The effects were evaluated by anthropometric measurement, biochemical analysis, questionnaire, and diet records before and after the program. RESULTS: Overweight-obese group showed significant decreases in weight (p < 0.0001), BMI (p < 0.0001), percent of body fat (p = 0.0087), waist circumference (p < 0.0001), systolic (p = 0.0003) and diastolic blood pressure (p = 0.0261). Nutrients intakes were not different between the two groups and only sodium intake was decreased after education. Total score of general dietary habits, dietary behavior related to sodium intake, dietary diversity score (DDS), diet variety score (DVS), and diet quality index-international (DQI-I) were improved in both groups compared to the baseline. Overweight-obese group showed significant improvement in 'having fruits everyday', 'having fish everyday', 'trying to eat many kinds of food', 'eating less broth when eating soup, stew, and noodles', 'eating less kimchi and salt-fermented vegetable', and 'propensity to think that dishes should be pretty seasoned'. In addition, moderation of empty calories food (p = 0.0064) and macronutrient ratio (p = 0.0004) were improved in the overweigh-obese group, but in the normal group, the results did not reach statistical significance. CONCLUSIONS: These results suggested that low sodium diet education program may contribute to obesity management by improving diet quality and dietary habits in middle-aged women.

Changes of Obesity Index, Serum Lipid Profiles and Nutrient Intakes in Obese Children after the Weight Control Program of Nutrition Education / 대한지역사회영양학회지

The purpose of this study was to evaluate the effect of a weight control program on anthropometric values, serum lipid profiles and nutrient intakes. The subjects of this study were 38 obese children (boy : 17, girl : 21) with obesity index over 120%. The weight control program for obese children included nutritional education (50 min) and exercise (50 min) for 10 weeks. The nutrition intakes of the children were surveyed before and after the weight control program by 24hr recall test. The BMI, Rohrer Index, Obesity Index, WHR (Waist - Hip ratio) and body fat(%) were significantly decreased after completion of the weight control program. The total cholesterol and HDL-cholesterol of subjects were significantly increased after the weight control program. Distribution of serum lipid profiles was slightly changed. The energy intakes were significantly decreased (p < 0.001). from 1760.8 kcal to 1435.2 kcal. In addition, the intakes of P, Zn, retinol, vitamin B1, vitamin B2, vitamin E and niacin were significantly decreased. while intakes of vitamin C and folate were increased. Calcium and folic acid were upper 25% of subjects, under EAR(Estimated Average Requirements) intake before the weight control program. The distribution of energy intakes was significantly changed into positive status; fat percentage was decreased 26.3% to 22.1% (p < 0.01). Carbohydrate was increased 58.6% to 61.2% (p < 0.05). Meal distribution of energy intakes was changed; calorie percentage from lunch significantly increased from 32.2% to 38.3%. Calorie percentage from snack significantly decreased from 17.7% to 13.5%. In conclusion, weight control program for 10 weeks is effective in obesity index and nutrient intakes although serum lipid values were a little changed.

The Relationship Between Intraocular Pressure and Age, Hypertension and Obesity Index in Ocular Hypertensive Patients

PURPOSE: To evaluate the relationship between intraocular pressure (IOP) and age, blood pressure and obesity index inocular hypertensive patients. METHODS: A total of 2684 ocular hypertensive patients underwent automated multi-phasic testing, including fundus photography, blood pressure and assessment of obesity. The subjects were divided into six age groups by decades ranging from 20~29 years to over 70 years of age. The relationships between factors were examined using multiple regression analysis. RESULTS: The mean participant age was 48.0+/-11.0 years, and 1,777 (66.3%) participants were male and 907 (33.7%) were female. The mean intraocular pressure (IOP) was 22.04+/-2.2 mmHg and was significantly higher in males than in females (p=0.023). The IOP was associated with mean blood pressure, gender and obesity index. After adjustment for mean blood pressure and obesity index, the relationship between IOP and age showed a significantly negative tendency (p<0.001). The relationship between IOP and obesity index adjusted for age and mean blood pressure had a significantly positive tendency (p<0.001), regardless of gender. The relationship between IOP and mean blood pressure adjusted for age and obesity index showed a significantly positive tendency (p=0.00014). CONCLUSIONS: IOP was associated with the mean blood pressure and obesity index. Regardless of gender, IOP decreased with age but increased with hypertension. It is necessary to check IOP regularly, especially in ocular hypertensive patients with systemic hypertension.

A Comparative Study Examining the Obesity Indices, Psychological Well-being Index Scores, and Nutrient Intakes of Daughters According to Their Mother's Degree of Obesity

The purpose of this study was to understand the effects a mother's degree of obesity has on her daughter's obesity index, psychological well-being index, and nutrient intakes. The daughters, as study subjects, were classified into two groups according to their mother's body mass index (BMI): an obese group [BMI>25 kg/m2, mother obesity group (MOG)] and a normal weight group [BMI<25 kg/m2, mother normal weight group (MNG)]. The daughters in MOG showed significantly higher percent ideal body weight values than the daughters in MNG (p<0.001). MOG and MNG had significantly different psychological well-being index scores in terms of being classified into a highly stressed group (p<0.001), potentially stressed group (p<0.05), and healthy group (p<0.001). Intakes of daily energy, protein, fat, thiamin, riboflavin, niacin, phosphorus, and iron were also significantly different (p<0.001) between MOG and MNG. In particular, the vitamin A and C intakes of the MNG daughters were significantly higher than those of the MOG daughters (p<0.001). Overall, the results showed that a mother's level of obesity was essentially related to her daughter's obesity index, psychological well-being index score, and nutrient intakes. Therefore, it seems necessary for mothers to maintain an ideal body weight to prevent obesity and diet related problems in their daughters.

Do mother's interests in weight control influence preschoolers' obesity and weight related concerns?

The purpose of this study was to assess the relationship between the mother's interest in weight control and its association with the preschooler's obesity and weight related concerns. This was a cross-sectional study based on 470 parents' self-reports. To score interests in weight control, mothers rated each of 6 items on a five-point Likert scale ranging from disagree (1) to agree (5). The perceptions of mothers' weights and their children's weights, mothers' Body Mass Index (BMI), preschoolers' Weight-Length Index (WLI) (%), and weight-related concerns were determined. The mothers' BMI was significantly correlated with interest scores of weight control in mothers (r=0.632, p<0.001) while their children's obesity was weakly correlated with the mothers' interest scores (r=0.133, p=0.025). Mothers with a high interest of weight control reported higher percentages of family history of obesity than mothers with lower interests (63.2% vs. 36.8%, p<0.001). Two-thirds of the mothers (65.4%) were accurate in their perceptions about their weights. Similarly, 63.7% of mothers knew exactly their children's weight-statuses. Compared with mothers with low interest in weight controls, mothers with high interest in weight control had lower correct-perceptions about their weights (p<0.05) but higher correct-perceptions about their children's weights. More than two-thirds of mothers (85%) reported not worrying about their children's obesity in the future. Only 14.3% of the mothers were satisfied with their current weight statuses. Three-fourths of mothers preferred exercise as an effective weight-control method for their children, 20% preferred diet therapy and 5.5% preferred behavior modification. More girls were overweight / obese, than boys (overweight: 16.1% (girl) vs. 12.8% (boy), obese: 5.4% (girl) vs. 4.5% (boy)). About 40% of overweight girls' mothers had low interests in their weight controls with low correct-perceptions in their children's weights, which suggests possible elevated risk of obesity, especially in girls, in the future.

Obesity Indices and Plasma Total Antioxidant Status in Hypertensive Elderly Living in Ulsan Area / 대한지역사회영양학회지

The role of free radicals in the progression of many diseases and aging has been given a great attention and total antioxidant status (TAS) has shown to be reduced with aging. The incidence of hypertension has shown to be relatively high in the aged population, and it is known to be associated with increased obesity and oxidative stress. The aim of this study was to examine the obesity indices and the total antioxidant status in hypertensive elderly (64y

The Prevalence of Elevated Serum Liver Enzymes in Obese Children / 대한소아소화기영양학회지

PURPOSE: With a remarkable increase in the prevalence of childhood obesity, the prevalence of nonalcoholic fatty liver disease is assumed to be increasing. The aim of this study is to evaluate the prevalence of nonalcoholic fatty liver disease, hyperlipidemia, and glucose intolerance in normal and obese children. METHODS: A total of 2,206 elementary students (boys: 1340, girls: 866) were grouped according to obesity index; normal group and obesity group (mild, moderate, severe). Aspartate aminotransferase (AST, SGOT) and alanine aminotransferase (ALT, SGPT) were measured with total cholesterol, triglyceride, and fasting blood glucose. RESULTS: Compared with the 4.6% of elevated aminotransferases in normal group, obese groups showed significantly higher prevalence; 12.1% in mild obesity group, 19.4% in moderate group, and 21.6% in severe group (p<0.0001). The prevalence of hypertriglyceremia was 16.9% in normal weight group, which was significantly lower than obesity group (mild obesity group 30.3%, moderate and severe 37.6%, 38.2% each). In boys, the prevalences of elevated aminotransferases in normal weight and obese groups (mild, moderate, severe) were 6.8%, 18.0%, 23.0%, and 26.0%, respectively (p<0.0001). In girls, those were 2.1%, 5.1%, 12.0%, and 12.6%, respectively (p<0.0001). The prevalence of hypertriglyceremia was relative to severity of obesity in boys and girls (p<0.0001). CONCLUSION: The prevalence of elevated serum liver enzymes increased with severity of obesity. For the prevention and treatment of fatty liver and hypertriglycemia, it is important to lower the obesity degree and enforce the education for a weight loss in the student and the parents.

Plasma Ghrelin Levels and Its Relationship with Obesity in Obese Children / 대한소아내분비학회지

Background:Ghrelin is a new endogenous ligand for the growth hormone secretagogue receptor. It activates the release of growth hormone from the pituitary and it also participates in the regualtion of energy homeostasis. The aims of the study were to characterize the changes in plasma ghrelin levels in obese subjects compared with lean control or overweight subjects, and their relationship to various parameters in obese subjects. METHODS:In this study, 121 elementary school children were divided into 3 groups according to their body mass index (BMI). The lean control subjects consisted of 28 children who had less than 85 percentile of BMI. The overweight subjects consisted of 22 children who had 85-95 percentile of BMI. The obese subjects consisted of 71 children who had over 95 percentile of BMI. All subjects in 3 groups were evaluated according to their age, height, weight, obesity index, plasma ghrelin, serum lipid, glucose and insulin levels. Leu72Met mutation of prepro-ghrelin gene was directly detected by digesting the PCR fragments with Bsrl. RESULTS:Among antropometric data, body weight, BMI and obesity index were higher in obesity and overweight subjects than those of lean control subjects (P<0.05). The plasma ghrelin levels were significantly lower in overweight and obese subjects (P<0.05). In addition, serum triglyceride and LDL cholesterol levels were significantly higher in these groups compared to the control subjects (P<0.05). The concentrations of plasma ghrelin were significantly negatively correlated with BMI, obesity index, serum triglyceride, LDL cholesterol and insulin in all the children. However, there was no significant relationship between plasma ghrelin levels and any various parameters in obese subjects. Leu72Met mutation was detected in about 30% of obese children. However, we could not find any differences between lean control and obese children. CONCLUSION: We proved a significantly lower plasma ghrelin levels in overweight and obese subjects. Further studies are now needed to establish the role of ghrelin in the pathogenesis of human obesity.

Childhood Obesity

Due to economic growth, and as lifestyles got more convenient, the number of calories being spent has decreased for two reasons. One is the lack of physical activities and the other is the increased consumption of westernized food. This outbreak of obesity is the highest among the children and the adolescents. Among primary, middle, and high school students in seoul, the prevalence of obesity has increased from 6.2% in 1988 to 17.9% in 2002 in boys, and from 6.5% to 10.9% during the same period in girls. Thus, during the last 14 years, the obesity frequency increased 2.9 times in boys, and 1.7 times in girls. Increase of child obesity is a worldwide tendency. In United States, 20% of all children, 27% of all adolescents, and 33% of all adults are obese. Childhood obesity is catching much attention, because it has physiological and psychological damages for long term as well as for short term. Some of the psychological damages of an obese children are having difficulties with familial and friend relation-ships, also having a low selfesteem. Although, physiological damages in short term are not clear, the long term damages would have progressed from an early age up to an adult. Detection and treatment of overweight and obesity in child-hood are important not only from the aspect of preventive pediatrics, but also the public health that in which include child's physical, social, and psychological health as well as the negative effect it will have on the adults.

Correlation between Mother's Characteristics and Biophysical Index in Obese Children / 여성건강간호학회지

PURPOSE: This study was performed to investigate the correlation between mother's characteristics and obesity index, percentage of body fat, total cholesterol, and serum leptin levels in obese children. METHOD: Sixty two students in 4th, 5th, and 6th grades were selected from two elementary schools located in the suburbs of Seoul. Mother's characteristics were collected by questionnaires. Biophysical indexes were as follows; obesity indexes were calculated by height and weight, percentages of body fat were measured by a bioelectrical impedence fatness analyzer, total cholesterol levels were measured by a Hitachi automatic analyzer, and serum leptin levels were measured by the immunoradiometric assay method. RESULT: The degree of mother's concern for their children's obesity showed a statistically significant positive correlation with biophysical indexes such as obesity index and serum leptin level in obese children. However, there were no significant correlations between mother's economic state, education level, occupation and biophysical indexes. Also, there were no significant correlations between mother's concern for their children's obesity and percentage of body fat, and serum cholesterol levels. CONCLUSION: These results indicate that mother's concern for their children's obesity is one of the most important factors in child obesity.

Effective Screening Test for Obesity in Obese Adolescents and the Correlation Among Obesity Index, Body Mass Index and Serum Lipid Profile

PURPOSE: Every year, there is a remarkable increase in the prevalence of children with excess body fat. The aim of this study is to find a useful screening method in assessing adolescent, obesity and to specify the predictable risk factors that are related to adult cardiovascular disease according to BMI and obesity index. METHODS: From July to November in 2001, a total of 2,814(male : female=2,011 : 803) mid to high school students who were in the obesity range according to obesity index(>20%) were evaluated according to height, weight, body mass index(BMI), obesity index, and serum lipid levels. RESULTS: Among the obese students over 20% by obesity index, 86.6% were over the range of 95 percentile by BMI. Among students defined as obese by BMI, 21.0% of males and 21.4% of females students had hypercholesterolemia; by obesity index, the ratio was 20.7% male and 19.0% female. The frequency of hypertriglyceremia in male students was 15.0% in group I(overweight group, 85P 97p); in female students 11.8%, 20.7% and 28.2% respectively. CONCLUSION: In this study, using BMI alone to test the serum lipid level in adolescent obesity had a limit of 10.0-17.0% omission. Therefore using obesity index as a screening method to find the adult cardiovascular disease would rather reduce the omission rate. The risk factor of cardiovascular disease according to BMI was the increasing level of triglyceride in both male and female students. We think that using the obesity index has more rationale rather than BMI in assessing lipid profiles.

Relationship between intraocular pressure and systemic health parameters in the Korean population

This study examined the influence of age, sex, blood pressure, and obesity index on intraocular pressure (IOP), in order to investigate the relationship between the upper limits of the following two conditions in the general Korean population: the "systolic or diastolic hypertensive and obese" group and the "systolic or diastolic hypotensive and lean" group. A total of 6828 healthy subjects (13,656 eyes) underwent automated multi-phasic tests, including tonometry, blood pressure, visual field, and body mass index. The 6,828 subjects were divided into five groups based on age; less than 40, 40 to 49, 50 to 59, 60 to 69, and over 70 years old. They were also divided into four categories on the basis of sex, age, blood pressure, and obesity index. The mean IOP in males (15.8+/-3.3 mmHg) was significantly higher than in females (14.8+/-3.1 mmHg) (P < 0.05), but this difference decreased proportionally with increasing age. IOP had a tendency to decrease with increasing age (P < 0.05). IOP increased significantly with increasing systolic blood pressure, diastolic blood pressure and obesity index (all, P < 0.05). The mean IOP of the "systolic or diastolic hypertensive and obese" group was higher than that of the "systolic or diastolic hypotensive and lean" group in the general Korean population (P < 0.05). These data could aid investigation into the epidemiological, etiologic and oriental influences related to the risk factors of glaucoma, especially in oriental populations.

A Study on Body Image Recognition, Food Habits, Food Behaviors and Nutrient Intake according to the Obesity Index of Elementary Children in Changwon / 대한지역사회영양학회지

No abstract available.

A Study on the Growth, Development and Obesity Index of Breast-feeding Infants / 아동간호학회지

This study is to identify the characteristics of the growth and deveolpment, and to assess Obesity Index, BMI and Kaup Index of infants paticipated in a healthy breast-feeding contest. The subjects of this study were 94 breast- feeding infants, ages from 6 to 8 months. Their weight and height were measured and compared with Korean Standards. Their developmental state was tested by DDST(Denver Developmental Screening Test) standardized in Korea. The data were analyzed by using the SPSS-WIN 10.0. The result is as follows : 1. The weight of infants was more than Korean Standards, but the height was less. 2. There were statistically significant differences in Obesity Index, BMI and Kaup Index. Obese infants estimated by Obesity Index were about 10%, but by BMI and Kaup Index were 35.1% and 27.7%. 3. Spearman's rhos of Obesity Index and Kaup Index, Obesity Index and BMI, and Kaup Index and BMI were individually 0.526, 0.528 and 0.753. In conclusion, BMI should be added to the criteria for assessing healthy breast-feeding infants.

A Study on the Growth, Development and Obesity Index of Breast-feeding Infants / 아동간호학회지

This study is to identify the characteristics of the growth and deveolpment, and to assess Obesity Index, BMI and Kaup Index of infants paticipated in a healthy breast-feeding contest. The subjects of this study were 94 breast- feeding infants, ages from 6 to 8 months. Their weight and height were measured and compared with Korean Standards. Their developmental state was tested by DDST(Denver Developmental Screening Test) standardized in Korea. The data were analyzed by using the SPSS-WIN 10.0. The result is as follows : 1. The weight of infants was more than Korean Standards, but the height was less. 2. There were statistically significant differences in Obesity Index, BMI and Kaup Index. Obese infants estimated by Obesity Index were about 10%, but by BMI and Kaup Index were 35.1% and 27.7%. 3. Spearman's rhos of Obesity Index and Kaup Index, Obesity Index and BMI, and Kaup Index and BMI were individually 0.526, 0.528 and 0.753. In conclusion, BMI should be added to the criteria for assessing healthy breast-feeding infants.

Plasma Leptin, Insulin Resistance, and Obesity Index of Type 2 Diabetics and Normal Subjects among Koreans / 대한내분비학회지

BACKGROUND: Leptin has been reported to be correlated with the amount of adipose tissue in humans. The plasma leptin concentrations were not different between diabetics and non-diabetics in Mexican-Americans; however, the leptin might stimulate or diminish insulin secretion and induce insulin resistance. Then, it can be postulated that leptin may one of the key factors in the development of insulin resistance. Therefore we were to note any differences in FPL (fasting plasma leptin levels) between diabetics and normal subjects, and to investigate variables such as PBF (percentage body fat), BMI (body mass index), FPI (fasting plasma insulin) to determine their effects on the variation of FPL. We also were to investigate whether FPL influenced the GUR (glucose utilization rate). METHODS: The subjects were 116 type 2 diabetics and 45 normal subjects in Korean. PBF, BMI, WHR (waist hip ratio) were measured. Fasting plasma insulin and leptin levels were measured by radioimmunoassay. Euglycemic and/or hyperglycemic clamp tests were performed in 19 diabetics and 16 normal subjects. RESULTS: 1. There was no difference in FPL between diabetics and normal subjects. 2. A significant difference was found in FPL between female and male subjects. 3. Gender and body composition such as PBF, BMI contributed plasma leptin levels. 4. FPL was associated with GUR (Insulin resiatance) only in male subjects. 5. During 2h clamp tests, the acute increments of insulin or glucose did not change the leptin levels. CONCLUSION: These data suggested that there was no difference in FPL between diabetics and normal subjects, whereas gender, body composition such as PBF, BMI contributed leptin levels.