Tratamento cirúrgico do mixoma odontogênico sem ressecção maxilar: relato de caso / Surgical Treatment od Odontogenic Mixoma Without Maxillary Resection: Case Report / Tratamiento Quirúrgico del Mixoma Odontogénico Sin Resección Maxilar: Informe de Caso

Mixoma Odontogênico é um tumor de origem mesenquimal raro, de desenvolvimento lento e agressivo que acomete indivíduos entre os 10 e 40 anos de idade e principalmente, do gênero feminino. Este estudo teve como principal objetivo descrever um caso clinico de tratamento cirúrgico do mixoma odontogênico sem ressecção maxilar em uma paciente do gênero feminino que compareceu ao Ambulatório de Patologia Oral e Maxilo Facial, da Faculdade de Odontologia da UNIRG, na cidade de Gurupi-TO - Brasil. A paciente foi submetida ao tratamento cirúrgico conservador, através da curetagem e enucleação total do tumor. A proservação foi realizada em períodos de 12 meses, 24 meses e 48 meses aonde pode-se observar a sequencial e completam reparação óssea, inclusive a permanência dos dentes envolvidos que foram submetidos a tratamento endodôntico com total remodelação da lâmina dura e do ligamento periodontal... (AU)

Odontogenic Myxoma (OM) is a rare tumor of mesenchymal origin, of slow and aggressive development that affects individuals between 10 and 40 years of age and mainly female. This study aimed to describe a clinical case of surgical treatment of odontogenic myxoma with out maxillary resection in a female patient who attended the Outpa tient Clinic of Oral Pathology and Facial Maxillo, of UNIRG Dental School, in the city of Gurupi-TO - Brazil. The patient underwent con servative surgical treatment through curettage and total enucleation of the tumor. Proservation was carried out in periods of 12 months, 24 months and 48 months where it was possible to observe the sequential and complete bone repair including the permanence of the involved teeth that underwent endodontic treatment with total remodeling of hard blade and of the periodontal ligament... (AU)

El mixoma odontogénico es un tumor de origen mesenquimal poco frecuente, de desarrollo lento y agresivo que afecta a individuos entre 10 y 40 años de edad y principalmente mujeres. El objetivo principal de este estudio fue describir un caso clínico de tratamiento quirúrgico de mixoma odontogénico sin resección maxilar en una paciente femenina que asistió a la Clínica Ambulatoria de Patología Oral y Maxilo Facial, de la Facultad de Odontología de UNIRG, en la ciudad de Gurupi-TO - Brasil. El paciente se sometió a tratamiento quirúrgico conservador mediante legrado y enucleación tumoral total. La conservación se realizó en periodos de 12 meses, 24 meses y 48 meses donde es posible observar reparación ósea secuencial y completa, incluyendo la permanencia de los dientes implicados que fueron sometidos a tratamiento endodóntico con remodelación total de la durancia y ligamento periodontal... (AU)

Perfil inmunohistoquímico del mixoma odontogénico, con énfasis en marcadores de agresividad tumoral y microdensidad vascular / Perfil imuno-histoquímico do mixoma odontogênico, com ênfase em marcadores de agressividade tumoral e microdensidade vascular / Immunohistochemical profile of odontogenic myxoma, with a focus on microvascular density and tumor aggressiveness markers

Con el fin de tener una mayor comprensión sobre el comportamiento biológico del mixoma odontogénico (MO), se realizó inmunohistoquímica en 31 muestras, utilizando marcadores relacionados con mecanismos de progresión tumoral (adhesión, angiogénesis, apoptosis, inflamación y proliferación celular). El epitelio odontogénico fue detectado en cuatro muestras mediante CK19 y CD138, este último, mostró expresión baja en matriz extracelular (MEC) y alta en las células tumorales. La microdensidad vascular (MDV) media fue de 7.51 y 5.35 vasos marcados con CD34 y VEGF-A respectivamente. Una alta expresión de Orosomucoide-1 y Mast Cell Tryptase se observó células tumorales y en MEC. El MO mostró negatividad para Calretinina. Este perfil inmunohistoquímico, la baja expresión para Ki-67, Bcl-2 y p53, y la relativamente baja MDV, sugieren que la actividad proliferativa, anti-apoptótica o angiogénica no representan los principales mecanismos de crecimiento del MO, los cuales podrían estar asociados a eventos como inmunomodulación y degradación de la MEC.

Immunohistochemistry tests were performed in 31 samples to elucidate the biological behavior of the odontogenic myxoma (OM), using markers related to mechanisms of tumor progression (adhesion, angiogenesis, apoptosis, inflammation and cell proliferation). Odontogenic epithelium was detected in four samples with CK19 and CD138; the latter had a low expression in the extracellular matrix (ECM) and a high expression in tumor cells. The mean microvascular density (MVD), assessed with CD34 and VEGF-A, was 7.51 and 5.35 blood vessels. A high expression of orosomucoid-1 and mast cell tryptase was observed in tumor cells and ECM, while calretinin was negative. The immunohistochemical profile mentioned above, as well as the low expression of Ki67, Bcl-2 and p53 and the relatively low MVD, suggest that the proliferative, antiapoptotic and angiogenic activities do not represent the main growing mechanisms of OM, which could be associated to other events, such as immunomodulation and ECM degradation.

Para melhor compreensão do comportamento biológico do mixoma odontogênico (MO), imuno-histoquímica foi realizada em 31 amostras, utilizando marcadores relacionados aos mecanismos de progressão tumoral (adesão, angiogênese, apoptose, inflamação e proliferação celular). Epitélio odontogênico foi detectado em quatro amostras por CK19 e CD138, o último mostrou baixa expressão na matriz extracelular (MEC) e alta em células tumorais. A microdensidade vascular (MDV) média foi de 7.51 e 5.35 vasos marcados com CD34 e VEGF-A, respectivamente. Uma alta expressão de Orosomucoide-1 e Mast Cell Tryptase foi observada nas células tumorais e na MEC. O MO mostrou negatividade para Calretinina. O perfil imuno-histoquímico mencionado acima, a baixa expressão de Ki-67, Bcl-2 e p53 e a relativamente baixa MDV, sugerem que a atividade proliferativa, anti-apoptótica ou angiogênica não representam os principais mecanismos de crescimento do MO, os quais poderiam estar associados com eventos como imunomodulação e degradação da MEC.

Fabrication of complete dentures for a patient with odontogenic myxoma: A case report / 대한치과보철학회지

Odontogenic myxoma of the jaws is a rare benign odontogenic tumor. In this case, a 61-year-old male patient had a chief complaint about maxillary anterior gingival mass and excisional biopsy result confirmed odontogenic myxoma. The clear acrylic resin custom tray was designed to minimize displacement of flabby tissue which remained after the surgery. Neutral zone and external impression technique could provide satisfactory result in terms of denture stability and retention during jaw relation record and wax denture try-in procedure. This clinical report describes fabrication of complete dentures for a patient with odontogenic myxoma in regard to flabby tissue and neutral zone.

Peripheral odontogenic myxoma.

Odontogenic myxomas are a rare benign odontogenic mesenchymal tumor found exclusively in the tooth‑bearing area of the jaw and are usually located centrally in the mandible. Soft tissue localization is rarely seen and is classified as peripheral odontogenic myxoma (POM). POM is slow growing and less aggressive as compared to central myxoma. It has a low recurrence rate, comprises 3–6% of all odontogenic tumors. Only a few cases of POM on maxillary gingiva are reported in the literature. Here, we present an unusual case of primary POM occurring in the gingiva of anterior maxilla in a 14‑year‑old female patient.

Odontogenic Myxoma of Mandible Appeared as an Ameloblastoma on CT Imaging.

Odontogenic myxoma is a rare benign tumor of ectomesenchymal origin, which can arise from dental papilla, follicle or periodontal ligament. Most commonly it arises from mandible followed by maxilla. We report a case of odontogenic myxoma in a 23 years old female who came with complaint of painless swelling in left mandible. CT scan revealed an expansile radiolucent lesion involving the left mandible body with cortical thinning and mild destruction at few places. Biopsy was done which was suggestive of odontogenic myxoma. Surgery was done and odontogenic myxoma was proved on the biopsy.

Odontogenic myxoma in children: case report

Odontogenic myxoma is a rare tumor, often diagnosed during routine radiographs or when it is so severe that it causes pain, a noticeable increase in volume or tooth displacement and mobility. Young adults (25-30 years of life) are more often affected by the lesion but all ages are vulnerable. The mandible is more commonly involved than the maxilla and the tumors usually grow slowly and silently. However, growth can be rapid and destructive. The radiographic aspect of a myxoma is that of a uni or multilocular, radiolucent lesion reminiscent of honeycomb or soap bubbles, depending on its size. It is an expansive tumor that may cause displacement or resorption of the teeth involved. Microscopically, the tumor is composed of round and spindle cells, with a star arrangement, arranged in a loose abundant myxoid stroma, containing only a few collagen fibrils. The treatment of choice is radical surgical excision because myxomas are not encapsulated and tend to infiltrate the surrounding bone. However, small tumors can be treated by curettage. Periodic reassessment is required for at least five years due to the high rate of recurrence. Larger tumors may need to be treated using a more extensive resection with a safety margin. This study reports a clinical case of odontogenic myxoma in a child aged 7 years. The tumor was located in the posterior region of the mandible and was surgically treated with an en bloc resection with preservation of the base of the mandible. The follow-up of the case is ongoing and no recurrence has been observed to date.

Odontogenic Myxomas with an Unusual Presentation in the Anterior Mandible: A Case Report

Odontogenic myxoma (OM) is a rare and locally invasive benign neoplasm derived from the odontogenic ectomesenchyme, found exclusively in the jaws. As a myxoma, this tumour consists mainly of spindle-shaped cells and scattered collagen fibers distributed through a loose, mucoid material. The lesion is found in age groups ranging from 10–50 years but commonly diagnosed in young adults (25–35 years). The lesion often grows without symptoms and presents as a painless swelling. It has variable radiographic presentation but often causing root displacement and resorption. In this article we present a rare case report of swelling in anterior mandible in a 31-year-old-male, diagnosed histopathologically as odontogenic myxoma.

Odontogenic Myxoma of Maxilla: Management and Follow-up of A Rare Case.

Odontogenic myxoma is a slow growing benign, locally malignant tumor, notorious for recurrence. It represents a broadspectrum of lesions of uncertain histogenesis with a characteristic histologic appearance. We report a rare case of odontogenic myxoma in a 10-year-old male patient and present the respective strategy for the management of a huge myxoma of right-side of maxilla via an intraoral approach after a brief review of its clinical and radiological features.

Clinico-radiographic examination of odontogenic myxoma with displacement of unerupted upper third molar: review of the literature / Examen clínico-radiográfico de un mixoma odontogénico con desplazamiento de un tercer molar no erupcionado: revisión de la literatura

Odotogenic myxoma is a benign tumor which presents in 3 percent to 6 percent of all odontogenic tumors. According to the WHO classification, multiple radiolucent areas of varying size, separated by straight or curved bony septa with poorly defined borders are the radiologic characteristics of the condition. We report the case of maxillary odontogenic myxoma in a 21 year old man. The radiological feature of the current case was interesting, due to the size of the lesion and severe displacement of the upper third molar.

El mixoma odontogénico es un tumor benigno que se presenta en el 3 por ciento a 6 por ciento de todos los tumores odontogénicos. De acuerdo a la clasificación de la OMS, las características radiológicas de esta patología presentan múltiples áreas radiolúcidas de tamaño variable, separadas por tabiques óseos rectos o curvos, con márgenes mal definidos. Presentamos un caso de mixoma odontogénico maxilar en un hombre de 21 años. La característica radiológica es interesante, debido al tamaño de la lesión y al desplazamiento severo del tercer molar superior.

Hypomethylation of tumor suppressor genes in odontogenic myxoma

Odontogenic myxoma (OM) is an ectomesenchymal benign odontogenic tumor characterized by spindle or stellate-shaped cells embedded in an abundant myxoid or mucoid extracellular matrix. DNA methylation is characterized by the addition of methyl groups in cytosines within CpG islands in the promoter gene. DNA methylation can decrease the expression of tumor suppressor genes and contribute to the development of neoplastic lesions. The aim of study was to evaluate the methylation pattern of the tumor suppressor genes P16 (CDKN2A), P21 (CDKN1A), P27 (CDKN1B), P53 (TP53) and RB1 in OM and dental pulp. Methylation was evaluated using methylation-specific polymerase chain reaction (PCR). The transcription was studied in some cases by using reverse transcription quantitative PCR. A higher frequency of unmethylated P27, P53, and RB1 samples was observed in the OM when compared with the dental pulp. OM expressed mRNA of all the genes evaluated. Considering all the samples together, the expression of Rb was higher in the unmethylated samples compared with the partially methylated samples. This investigation revealed hypomethylation of the genes P27, P53, and RB1 in OM. In addition, methylation of tumor suppressor genes was found to be an usual event in normal dental pulp.

O mixoma odontogênico (MO) é um tumor odontogênico benigno de origem mesenquimal caracterizado pela presença de células fusiformes ou estreladas dispostas em abundante matriz extracelular mucóide. A metilação do DNA é caracterizada pela adição de grupos metil em citosinas constituintes de ilhas CpG na região promotora do gene. A metilação pode diminuir a expressão de genes supressores de tumor e contribuir para o desenvolvimento de lesões neoplásicas. O objetivo deste trabalho foi avaliar o padrão de metilação nos genes P16 (CDKN2A), P21 (CDKN1A), P27 (CDKN1B), P53 (TP53), RB1 nos MO e na polpa dental. A metilação foi avaliada pela reação em cadeia da polimerase específica para a metilação. A transcrição dos genes foi estudada em alguns casos pela reação da transcriptase reversa (PCR quantitativa). Uma maior frequência de amostras não metiladas para os genes P27, P53 e RB1 foi observada nos MO quando comparados à polpa dental. Os MO expressaram RNAm de todos os genes avaliados. Considerando todas as amostras juntas, a expressão de Rb foi maior em amostras não metiladas comparadas as amostras parcialmente metiladas. Esta investigação mostrou a hipometilação dos genes P27, P53 e RB1 nos MO. Adicionalmente, a metilação nos genes supressores de tumor é um evento frequente em polpa dental normal.

Mixoma odontogénico / Odontogenic myxoma

El mixoma odontogénico se considera una neoplasia benigna, poco frecuente, de consistencia firme y gelatinosa, de crecimiento lento con potencial infiltrativo que produce expansión de la cortical con extensa destrucción ósea y alto índice de recidiva. De origen ectomesenquimàtico, probablemente derivado del órgano dentario. No existe una predilección particular por sexo, y si una ligera preferencia por presentarse en mandíbula, generalmente asintomàtico. Se presenta una paciente femenina de dieciséis años de edad, color de la piel blanca, con antecedentes de salud, que acude a consulta de cirugía màxilo facial por aumento de volumen de hemicara derecha, sin otra sintomatología acompañante. Al examen físico se observa aumento de volumen en región maxilar derecha. Al realizar tomografía axial computarizada se observó lesión hiperdensa que ocupaba todo el seno maxilar derecho, con àreas de mayor densidad, que respetaba el hueso que conforma el piso de la órbita. Bajo anestesia general naso traqueal se le realizó hemimaxilectomia, retirada de tumor y colocación de prótesis inmediata obturadora. Después de un año de evolución clínica y radiogràfica se colocó la prótesis definitiva, sin presencia de recidiva tumoral(AU)

An odontogenic myxoma is a uncommon benign neoplasm of a gelatinous and solid consistency, of lengthy growing with a infiltration potential producing an cortex expansion of with and extend bone destruction and a high rate of relapse. Its origin is ectomesenchymal, probably derived from dental organ. There is not a particular sexual preference, but a slight one by be present in mandible and generally asymptomatic. This is the case of a female white patient aged 16, with health backgrounds referred to Maxillofacial consultation due to an of right hemifacial increase without another accompanying symptomatology. At physical examination there is an increase in volume of right maxillary region. In computerized axial tomography (CAT) a hyperdense lesion occupying all right maxillary sinus with areas of higher density without affecting the orbit floor bone. Under nasotracheal general anesthesia a hemimaxillotomy was carried out, tumor removal and obturator immediate prosthesis placing. At a year of clinical course and radiography definitive prosthesis was placed without tumor relapse(AU)

Distraction Osteogenesis Followed by Implant Installation on the Reconstructed Mandible with a Free Iliac Bone Graft in a OdontogenicMandibular Myxoma Patient: Case Report

Odontogenic Myxoma of Maxilla: A Case Roport

Odontogenic Myxoma of the jaws is a rare benign tumor derived from embryonic mesenchymal elements of dental anlage. It appears to originate from the dental papilla, follicle or periodontal ligament. Odontogenic Myxoma of the maxilla is less frequent but behaves more aggressively than that of the mandible, because it spreads through the maxillary sinus. Radiographically, the tumors present as unilocular or multilocular radiolucent lesions with well-defined borders with fine, bony trabeculae. On gross examination, the tumor appears as a smooth, glistening, gelatinous, lobulated mass. On microscopic examination, these neoplasms exhibit loose arrangement of stellate-shaped cells. The intercellular substance is a mucinous and homogeneous matrix. We report a case of odontogenic myxoma of the maxilla observed in our clinic with good prognosis after partial maxillectomy.

Odontogenic myxoma of the mandible: Report of a case

A case of odontogenic myxoma related to both impacted canine teeth in the mandible

Odontogenic myxoma is a rare tumor which occurs almost exclusively in the jaws, and seems to be of odontogenic origin. Clinically this tumor tends to appear in the second and third decades of life, and most of the lesions are located in the premolar - molar region. It is characterized grossly by mucoid or gelatinous gray-whitish tissue that replaces the cancellous bone and expands the cortex. It is invasive locally and has a high recurrence rate ranging from 10% to 33%. Radiographically, the appearance of this tumor is varied, but usually appears as a unilocular or multilocualr radioluscency of varying size. We experienced a rare case of odontogenic myxoma 12 years old patient related to mandibular bilateral impacted canines in the mandible, so we report this case with literature.

Odontogenic Myxoma: Report of Two Cases

Odontogenic myxoma is one of rare tumors in oral and maxillofacial region and it is thought to be mesenchymal or ectomesenchymal origin. Its characteristics are benign and non-metastatic but it has the potential of local invasion and high recurrence rate. It originally occurs in atrium of heart and in central case, my xoma is located mainly in the maxilla and mandible. Most odontogenic myxoma develops in 2nd or 3rd decades of life and rarely occurs in child or older persons over fifty. The distribution of reported cases between the sexes is similar and the maxilla and mandible are equally affected or slightly higher in mandible. Clinically it is usually asymptomatic, however it can cause pain and paresthesia is complained in the advanced stages. Displacement and mobility of teeth have also been reported Odontogenic myxoma is not a frequent tumor, but in case of slow and painless growing tumor it must be considered as a differential diagnosis.