Management of Recurrence of Ameloblastoma and Odontogenic Keratocyst: A Cross-Sectional Study / Manejo de la recurrencia del ameloblastoma y keratoquiste odontogénico: Estudio de corte transversal

Abstract Objectives: Odontogenic keratocyst (OKC) and ameloblastoma are slowly growing and locally invasive tumors with high recurrence rate. The aim of this study was to investigate the clinicopathologic features of recurrent ameloblastoma and OKC cases, and evaluate outcomes of our treatments in terms of recurrence. Material and Methods: A total of 23 patients with confirmed recurrent ameloblastoma or OKC and treated in our clinic within eleven years period were reviewed retrospectively. Results: Eleven recurrent OKC cases and twelve recurrent ameloblastoma cases were included. Most recurrences occurred within five years after the initial treatment (69.6%). Enucleation had the highest recurrence rate among the first treatments (18/23). All recurrences were located in the mandible, with one exception (22/23). All recurrent OKCs were multilocular. Different histopathologic subtypes of ameloblastoma were seen in our study, follicular ameloblastoma was the most common (8/12). The mean diameter of the lesions was 4.3 cm (ranging from 2 cm to 7 cm). Statically significant relation was found between location and diameter of lesion and year of recurrence onset (p=0.004; p=0.026). We performed radical treatments in these cases (ten patients underwent marginal resections, and thirteen patients underwent segmental resection), and no recurrence was observed during the follow-up period. Conclusion: Previous inadequate surgical procedures were the most important cause of recurrence. Marginal or segmental resection with safety margins is the best method to treat recurrences of OKC or ameloblastoma cases.

Resumen Objetivo: Los keratoquistes odontogénicos (KQO) y ameloblastomas son tumores invasivos de lento crecimiento local con una alta tasa de recurrencia. El propósito de este estudio fue investigar las características clínico patológicas de los casos de ameloblastoma y KQO recurrentes y evaluar los resultados de tratamientos en término de recurrencia. Materiales y Métodos: Un total de 23 pacientes con casos confirmados de ameloblastomas o KQO recurrentes tratados en nuestra clínica en un período de once años fueron incluidos. Resultados: Once casos de KQO recurrentes y doce ameloblastomas recurrentes fueron incluidos. La mayoría de las recurrencias ocurrieron en los primeros 5 años posteriores al tratamiento inicial (69.6%). La enucleación mostró la tasa de recurrencia más alta entre los tratamientos iniciales (18/23). Todas las recurrencias se presentaron en la mandíbula excepto por un caso (22/23). Todos los KQO fueron multiloculares. Distintos subtipos histológicos del ameloblastoma fueron detectados en el estudio y el ameloblastoma folicular fue el más común (8/12). El diámetro promedio de las lesiones fue de 4.3cm en un rango de 2cm a 7cm. Una relación estadísticamente significativa se encontró entre la ubicación y el diámetro de la lesión y el tiempo de aparición de la recurrencia (p=0.004; p=0.026). Se realizaron tratamientos radicales en los siguientes casos, diez pacientes tuvieron resecciones marginales y trece pacientes resección segmental; no se observaron recurrencias en el período de seguimiento. Conclusión: Procedimientos previos inadecuados fueron la causa más relevante de recurrencia. Resección marginal o segmental con márgenes de seguridad son el mejor método para tratar casos de ameloblastoma y KQO recurrentes.

Peripheral Developing Odontoma or Peripheral Ameloblastic Fibro-Odontoma Erupting to Oral Cavity Case Report / Odontoma en Desarrollo Periférico o Fibro-Odontoma Ameloblástico Periférico Eruptando a Cavidad Oral Reporte de Caso

ABSTRACT: The appearance of mixed odontogenic tumors into the oral cavity is a rare event. It is considered that some mixed tumors are only a stage in the complete development of a hamartomatous formation such as ameloblastic fibroodontoma and odontoma. Both pathologies share in common cellular elements which at one point makes them indistinguishable from each other. We present the case of a 21 year old patient who showed a mandibular growth whose histological elements present characteristics of both pathologies. The treatment was surgical excision of the lesion. There were no complications or recurrences to periodic reevaluation.

RESUMEN: La aparición de tumores odontogénicos mixtos en la cavidad oral es un evento raro. Se considera que algunos tumores mixtos son solo una etapa en el desarrollo completo de una formación hamartomatosa como el fibro-odontoma ameloblástico y odontoma. Ambas patologías comparten elementos celulares comunes que en un punto los hacen indistinguibles entre sí. Presentamos el caso de un paciente de 21 años que mostró un crecimiento mandibular cuyos elementos histológicos presentan características de ambas patologías. El tratamiento fue la escisión quirúrgica de la lesión. No hubo complicaciones o recurrencias a la reevaluación periódica.

Peripheral odontogenic myxoma in a 12-year-old girl: a rare entity

Peripheral odontogenic myxoma is a rare odontogenic tumor representing an extra osseous counterpart of central odontogenic myxoma. It is commonly seen in gingiva between the 3rd and 4th decades of life and appears predominantly in females. Compared to central odontogenic myxoma, it is a less aggressive, slow-growing lesion with a low recurrence rate. However, close postoperative follow-up is required because of the unlimited growth potential of incompletely removed lesions. It shares many features with other soft tissue myxoid proliferations occurring in the oral cavity and hence needs to be differentiated from them. Very few cases of peripheral odontogenic myxomas have been reported and, to the best of our knowledge, no case has been reported in a pediatric patient. We present an unusual case of peripheral odontogenic myxoma occurring in a 12-year-old girl located in the anterior mandibular gingiva, with an emphasis on differential diagnosis.

Cementoblastoma benigno: relato de caso / Benign Cementoblastoma: Case Report

O cementoblastoma benigno ou cementoma verdadeiro é uma neoplasia odontogênica benigna. Acredita-se que essa lesão é a única neoplasia verdadeira do cemento. Ela apresenta incidência entre 1 e 6,2% dentre os tumores odontogênicos, o que vem a tornála rara. Sendo assim, o objetivo do presente trabalho foi relatar o caso clínico de uma paciente com diagnóstico de cementoblastoma benigno, enfatizando as peculiaridades desse tumor, a importância do diagnóstico correto e o estabelecimento de um tratamento adequado, bem como ressaltar a importância da proservação do caso.

Benign cementoblastoma or true cementoma is a benign odontogenic tumour. It is believed that this lesion presents the unique true cementum neoplasm. It is a rare lesion comprising 1 to 6,2% of odontogenic tumours. Therefore, the objective of this study was to report the case of a patient diagnosed with benign cementoblastoma, emphasizing the peculiarities of this tumor, the importance of correct diagnosis and appropriate treatment setting, as well as underscoring the importance of proactive observation.

Odontogenic Tumour Patterns- An Introspective Analysis.

Odontogenic tumours encompass a diverse group of uncommon tumours that are frequently aggressive in their biological behaviour. They comprise 2.4% of all the lesions biopsied in the dental office. Odontogenic tumours have for years been recognized for presenting clinical & histopathological challenges arising from epithelial, ectomesenchymal and/or mesenchymal elements of tooth forming tissues. Understanding of the most common and rare odontogenic tumours will be of great use in their study and clinical management. Histological patterns and sub-patterns are characteristic of particular tumours, hence serve as a proverbial beacon to arrive at a confirmatory histopathological diagnosis. The molecular mechanisms of Epithelial Mesenchymal Interaction have long been studied as a basis for these versatile tumour patterns. Morphogenesis and cell differentiation in the developing tooth are controlled by a series of reciprocal interactions between the epithelial and mesenchymal tissues. In these rare neoplasms, there is lack of information about ectomesenchymal interactions which is involved in the pathogenesis of these tumours. Our paper aims to assess the validity of tumour pattern as a unique prognostic parameter for odontogenic tumours.

Odontogenic Myxomas with an Unusual Presentation in the Anterior Mandible: A Case Report

Odontogenic myxoma (OM) is a rare and locally invasive benign neoplasm derived from the odontogenic ectomesenchyme, found exclusively in the jaws. As a myxoma, this tumour consists mainly of spindle-shaped cells and scattered collagen fibers distributed through a loose, mucoid material. The lesion is found in age groups ranging from 10–50 years but commonly diagnosed in young adults (25–35 years). The lesion often grows without symptoms and presents as a painless swelling. It has variable radiographic presentation but often causing root displacement and resorption. In this article we present a rare case report of swelling in anterior mandible in a 31-year-old-male, diagnosed histopathologically as odontogenic myxoma.

Basal Cell Ameloblastoma: Report of a Rare Case with Review of Literature

Ameloblastoma is a benign tumour of odontogenic epithelial origin with several histological variants comprising of follicular, plexiform, acanthomatous, desmoplastic, granular cell and basal cell types. Basal cell ameloblastoma (BCA) is the rarest histologic subtype in which the tumour is composed of numerous odontogenic epithelial islands supported by fibrous connective tissue stroma. It exhibits variations in the clinical course and histological features compared with the classic type of ameloblastoma. Till date, only 11 cases of BCA have been reported in the literature. Considering the rarity of the lesion, we report here a unique case of BCA occurring in the 8th decade with review of the literature of this rare variant.

Cellular proliferation markers in peripheral and central fibromas: a comparative study

ABSTRACT Objective: To perform a comparative study of the cellular proliferation in the peripheral and central fibromas. Material and Methods: Immunohistochemistry for PCNA and the AgNOR technique were performed in 9 cases of peripheral odontogenic fibroma (POF), in 4 cases of odontogenic fibroma (OdF), in 8 cases of peripheral ossifying fibroma (PEOF) and 7 cases of ossifying fibroma (OsF). The Kruskal-Wallis and Mann-Whitney tests were used for the statistical analyses. Results: Mesenchymal component of the central lesions presented a higher mean number of AgNOR per nucleus and PCNA index than did the peripheral lesions (P≤0.05). The mean number of AgNOR per nucleus in the epithelial component proved to be higher in the OdF than in the POF (P≤0.05). The mesenchymal and epithelial components presented similar mean numbers of AgNOR per nucleus and PCNA index in the OdF, as well as a similar mean number of AgNOR per nucleus in the POF. Conclusions: The mesenchymal component may well play a role in the differences between the biological behaviour of the central lesions as compared to the peripheral lesions. Moreover, considering that the epithelial and mesenchymal components in odontogenic fibromas presented a similar proliferation index, more research is warranted to understand the true role of the epithelial components, which are believed to be inactive in nature, as well as in the development and biological behaviour of these lesions. .

Imuno-expressão da DNMT1, DNMT3a e DNMT3b nos tumores odontogênicos / DNA methyltransferase 1, 3A and 3B immunohistochemical expression in odontogenic tumours

Os tumores odontogênicos são um grupo heterogéneo de lesões formadas a partir de tecidos que dão origem ao dente. A metilação do ADN, uma adição covalente de um grupo metilo na posição 5 de carbono de um nucleótideo de citosina, é considerado um importante regulador da expressão génica. A adição do radical metil é catalisada por ADN metiltransferases (DNMTs). Embora alguns estudos epigenéticos tenham sido realizados em tumores odontogênicos, um estudo com os três tipos de DNMTs em vários membros desse grupo está em falta. Este estudo analisa a expressão de DNMTs em tumores odontogênicos. Amostras de vinte ameloblastomas, dez Calcificante tumores odontogênicos císticos, dez calcificados tumores epiteliais, dez tumor odontogênico adenomatóide, dez tumores odontogênicos queratocísticos, quatro fibromas ameloblásticos, dois fibro-odontoma ameloblástico, quatro fibroma centrais odontogênicos, sete tecidos de fibromas odontogênicos periféricos e dez mixomas odontogênicos foram incluídos. DNMT1, 3A e 3B foram expressas no núcleo e / ou citoplasma de todos os tumores odontogênicos. A alta expressão de DNMTs em células de tumor odontogênico sugere metilação como um mecanismo importante para este grupo de tumores.

Odontogenic tumours are a heterogeneous group of lesions formed from tissues that give rise to the tooth. DNA methylation, a covalent addition of a methyl group to the 5-carbon position of a cytosine nucleotide, is considered an important regulator of gene expression. The addition of the methyl radical is catalyzed by DNA methyltransferases (DNMTs). Although some epigenetic studies have been conducted in odontogenic tumours, a study with the three types of DNMTs in several different members of this group is missing. This study analyzes the expression of DNMTs in odontogenic tumours. Formalin-fixed and paraffin-embedded tissue samples of twenty ameloblastomas, ten calcifying cystic odontogenic tumors, ten calcifying epithelial tumors, ten adenomatoid odontogenic tumors, ten keratocystic odontogenic tumors, five ameloblastic fibromas, two ameloblastic fibro-odontoma, four central odontogenic fibroma, seven peripheral odontogenic fibroma and ten odontogenic mixoma were included. DNMT1, 3A and 3B were expressed in the nucleus and/or cytoplasm of all odontogenic tumours. The high expression of DNMTs in odontogenic tumour cells suggests methylation as an important mechanism for this group of tumours.

Peripheral Ameloblastoma - A Case Report With Emphasis On Etiopathogenesis.

Peripheral ameloblastoma, a rare and unusual variant of odontogenic tumour, comprises about 1% of all ameloblastomas. The extraosseous location is the peculiar feature of this type of tumour, which is otherwise similar to the classical ameloblastoma. It appears in the gingiva and oral mucosa and it usually does not show any bone involvement on radiographs, except for saucer shaped erosion of underlying alveolar bone. Recurrence is considered uncommon. We report a case of peripheral ameloblastoma of maxillary gingiva.

Synchronous pleomorphic adenoma and periapical cyst: clinical case report / Adenoma pleomorfo e cisto periapical sincrônicos: relato de caso clínico

The pleomorphic adenoma or mixed benign tumor is the most common benign neoplasia of the salivary gland in human beings. It preferentially occurs in the superficial lobe of the parotid gland. In the oral cavity, associated with the minor salivary glands, it has a greater predilection for the palate region, with slight predisposition in women between the 3rd and 4th decades of life. The radicular cyst is an odontogenic inflammatory cyst resulting from pulp lesions caused by traumas or caries. In spite of being relatively common, there are no reports of association with salivary gland tumors. The aim of this work is to report a case of a 36-year-old woman patient, who presented with synchronous development of a pleomorphic adenoma and periapical cyst within the same region. The option taken was to perform enucleation of both lesions,followed by local curettage. The patient has been followed-up clinically and radiographically for around 18 months without signs of recurrence.

O adenoma pleomórfico ou tumor misto benigno é a neoplasia benigna mais comum primária de glândula salivar. Ocorre preferencialmente no lobo superficial da glândula parótida. Na cavidade oral, associado com as glândulas salivares menores, tem uma maior predileção para a região do palato, com ligeira predisposição em mulheres entre a 3 ª e 4 ª décadas de vida. O cisto radicular é um cisto odontogênico inflamatório decorrente de lesões causadas por traumas ou cárie. Apesar de ser relativamente comum, não há relatos de cistos periapicais associados com tumores de glândula salivar. O objetivo deste artigo é relatar um caso de uma paciente de 36 anos de idade com desenvolvimento sincrônico de adenoma pleomorfo e cisto periapical em uma mesma região. A opção tomada foi a de realizar a enucleação de ambas as lesões, seguido de curetagem local. A paciente está sendo acompanhada clínica e radiograficamente por cerca de 18 meses sem sinais de recidiva.

Cementoblastoma benigno: relato de caso / Benign cementoblastoma: a case report

Cementoblastoma benigno é uma neoplasia odontogênica relativamente rara caracterizada, pela formação de uma massa de tecido semelhante ao cemento, em conexão com a raiz do dente. Radiograficamente está aderido à porção apical ou lateral da raiz e se apresenta como uma massa radiopaca densa, bem delimitada e circundada por um halo radiotransparente fino e uniforme. Neste artigo, os achados clínicos e radiográficos de um caso de Cementoblastoma benigno são apresentados.

Benign cementoblastoma is a relatively rare odontogenic neoplasm characterized by the formation of a mass of cementum-like tissue, connected to the root of the tooth. Radiographically, it is attached to the apical or lateral root and presents as a well-defined, dense radiopaque mass, surrounded by a thin and uniform radiolucent halo. In this article, the clinical, radiographic and therapeutic features of a case of benign cementoblastoma are presented.

Radiographic interpretation of unilocular radiolucent mandibular lesions

The main goal of this study was to identify the main distinctive radiographic characteristics of different unilocular radiolucent mandibular lesions based on the criteria used by different groups of specialists during the process of radiograph interpretation to arrive at a correct diagnosis. A total of 24 panoramic radiographs were selected exhibiting the following lesions: ameloblastoma, keratocystic odontogenic tumor, dentigerous cyst and simple bone cyst. Six cases of each pathology were analyzed by 3 specialists from 4 related areas (pathologists, stomatologists, radiologists and oral surgeons). A number of important distinctive features and confounding characteristics that are liable to misinterpretation were pointed out by the specialists during the analysis. The method of generalized estimating equations (GEE) was used to estimate the probability of correct diagnosis according to the specialization of the examiner and the type of lesion and no significant relation was found (p>0.05 for all variables). The overall percentage of correct diagnosis among the specialists was around 56%, which shows that these lesions are of difficult radiographic diagnosis. Although the specialty of the examiners did not influence the results, i.e., the 4 different kinds of specialists showed the same diagnostic capacity, the criteria used for interpreting the same lesions were often different among the specialists. The compilation of these criteria enabled the identification and selection of some useful distinctive radiographic characteristics to formulate diagnostic hypothesis of unilocular radiolucent lesions. The radiographic diagnosis of the unilocular radilucent mandibular lesions is particularly difficult and the histopathological examination is essential to make the definitive diagnosis.

O objetivo deste estudo foi identificar as principais caracteristicas radiograficas para a diferenciacao de lesoes radiolucidas uniloculares mandibulares, por meio dos criterios utilizados por diferentes grupos de especialistas durante o processo de interpretacao radiografica para a obtencao dos diagnosticos corretos das lesoes. Vinte e quatro radiografias panoramicas foram selecionadas exibindo as seguintes lesoes: ameloblastoma, tumor odontogenico queratocistico, cisto dentigero e cisto osseo simples. Seis casos de cada entidade patologica foram analisados por 3 especialistas de 4 areas diretamente relacionadas a diagnostico (patologistas, estomatologistas, radiologistas e cirurgioes buco-maxilo-faciais). Inumeras caracteristicas importantes tanto para a correta distincao quanto para a ocorrencia de confusao entre as lesoes, foram levantadas pelos especialistas durante a analise. O metodo de equacoes de estimacao generalizada (EEG) foi utilizado para estimar a probabilidade do acerto do diagnostico segundo a especialidade do examinador e o tipo de lesao, nao sendo encontrada relacao significativa (p>0.05 para todas as variaveis). A porcentagem geral de diagnostico correto entre os especialistas ficou em torno de 56%, o que mostra que estas lesoes sao de dificil diagnostico radiografico. Embora a especialidade dos examinadores nao tenha influenciado os resultados, isto e, os 4 tipos de especialistas mostraram a mesma capacidade diagnostica, os criterios utilizados para a interpretacao das mesmas lesoes foram frequentemente diferentes entre os especialistas. A compilacao desses criterios possibilitou a identificacao e selecao de algumas caracteristicas radiograficas distintivas uteis na formulacao de hipoteses diagnosticas de lesoes radiolucidas uniloculares. O diagnostico radiografico das lesoes radiolucidas uniloculares mandibulares e particularmente dificil e a analise histopatologica e essencial para a obtencao do diagnostico definitivo.

Carcinoma escamocelular intraóseo primario mandibular: reporte de caso / Primary intraosseous squamous cell carcinoma of the mandible: case report / Carcinoma mandibular intra-ósseio primário de células escamosas: relato do caso

El carcinoma escamocelular intraóseo primario mandibular se encuentra, de acuerdo con la clasificación de la Organización Mundial de la Salud, dentro de los carcinomas odontogénicos. Se trata de una neoplasia poco común, con una relación hombre:mujer de 3,5:1 y una mayor frecuencia de presentación entre la quinta y la sexta década de vida. Su localización más común es en la región posteroinferior mandibular, siendo localmente agresivo, con metástasis a ganglios linfáticos regionales. Debido a que su comportamiento es intraóseo y a que no presenta lesiones iniciales intraorales, su diagnóstico clínico es difícil, durando largos periodos sin que se sospeche su presencia. Confirmar su diagnóstico requiere de un estudio anatomopatológico que detecte la presencia de células epiteliales carcinomatosas intraóseas. Imagenológicamente se evidencia como una lesión quística atípica, mal definida en la mayoría de los casos, radiolúcida y con osteolisis. El tratamiento de elección, con fines curativos, es la realización de una exéresis con amplios márgenes de seguridad oncológica y una posterior cirugía reconstructiva. Se presenta en este artículo el caso de un paciente de 31 años de edad con un carcinoma escamocelular intraóseo primario de la mandíbula tipo sólido, al que se le realizó una resección mandibular derecha en bloque, seguida de cirugías reconstructivas hasta obtener un adecuado resultado funcional y estético...

The primary intraosseous squamous cell carcinoma of the mandible is classified by the World Health Organization within the odontogenic carcinomas. It is a rare disease. Epidemiologically the male: female ratio is 3,5:1. The highest incidence is in the fifth and sixth decades of life. The most affected area is the posteroinferior mandibular region. It is a locally aggressive tumor that metastasizes to regional lymph nodes. The clinical diagnosis is difficult, because their behavior is intraosseous so it can last long periods of time before the diagnosis is made. It requires a pathological study which detects the presence of intraoseus carcinomatous epithelial cells. Imaging shows a radiolucent lesion with osteolysis in the form of atypical cystic lesions poorly defined in most cases. The treatment of choice for curative purposes is to provide an excision with wide safety margins and subsequent reconstructive surgery. We present a 31 years old patient with a primary mandibular intraosseous squamous cell carcinoma (solid type), whose treatment consisted of an en bloc resection and right mandibular reconstructive surgeries to obtain an adequate functional and aesthetic result...

O carcinoma de preliminar intrabony escamocelular a mandibular está, no acordo com a classificação da organização World-wide da saúde, dentro dos carcinomas dos odontogénicos. Neoplasia é um pouco comum, com um homem da relação: mulher de 3,5:1 e uma freqüência mais grande da apresentação entre a quinta e sexta década da vida. Sua posição mais comum está na região do posteroinferior a mandibular, sendo localmente aggressive, com o metástasis ao ganglia lymphatic regional. Porque seu comportamento é intrabony e àquele não se apresentar/exposição os ferimentos iniciais intraoral, seu diagnóstico clínico é períodos longos difíceis, durando sem sua presença é suspeitado. Confirmar seu diagnóstico requer de um estudo do anatomopatológico que detecte a presença de pilhas epithelial dos carcinomatosas intrabony. Imagenológicamente é demonstrado como um ferimento atypical do quística, bad definido em a maioria dos casos, radiolúcida e com o osteolisis no formulário do L. O tratamento da eleição, com alvos dos curativos, é a realização de um exéresis com margens de segurança amplas do oncológica e uma cirurgia mais atrasada do reconstructiva. O exemplo de um paciente de 31 anos de idade com um carcinoma aparece neste artigo de preliminar intrabony escamocelular do tipo contínuo da maxila, a que um resección lhe foi feito à direita mandibular no bloco, seguido de cirurgias dos reconstructivas até obter um resultado funcional e aesthetic apropriado...

Desmoplasic ameloblastoma in maxilla: report of case and review of the literature / Ameloblastoma desmoplásico en la maxila - relato de un caso y revisión de la literatura

The ameloblastoma is a benign neoplasm of epithelial odontogenic origin, slowly growing, locally invasive and it is the most common odontogenic tumor in the jaws. Histologically, various types have been described in literature. The desmoplastic variant is rare and characterized by difference in the typical findings of ameloblastoma, including localization, radiographic and histological features. The purpose of this article is to report a case of desmoplastic ameloblastoma in the left maxilla, and review of relevant literature, emphasizing peculiar aspects of this unusual lesion.

El ameloblastoma es una neoplasia benigna de origen epitelial odontogénica de crecimiento lento, localmente invasiva y constituye el tumor odontogénico más común en los maxilares. Histológicamente, existen varios tipos descritos en la literatura. La variante desmoplástica es rara y se caracteriza por diferencias en los hallazgos típicos del ameloblastoma, incluso la localización y aspectos radiográficos e histológicos. Los objetivos de este artículo son relatar un caso de ameloblastoma desmoplásico en el lado izquierdo del maxilar superior y presentar una revisión de la literatura relevante, enfatizando aspectos peculiares de esta rara lesión.

Extraosseous calcifying odontogenic cyst: a case report and a literature review

The calcifying odontogenic cyst is an uncommon odontogenic lesion that can have intra- or extraosseous occurrence with both cystic or tumor behavior. A report of an extraosseous calcifying odontogenic cyst (ECOC) in a 57-year-old black woman is presented as well as a review of the literature about the lesion. The clinical, radiographic and histopathologic features are discussed, along with etiology and treatment.

O cisto odontogênico calcificante é uma lesão odontogênica incomum que pode ser intra ou extra-óssea, tanto com um comportamento cístico quanto com um comportamento neoplásico. Neste trabalho está sendo apresentado o relato de um caso de cisto odontogênico calcificante em uma mulher da raça negra, com 57 anos de idade, bem como uma revisão da literatura sobre a lesão. Os achados clínicos, radiográficos e histopatológicos são discutidos, assim como sua etiologia e o seu tratamento.