Effect of cisapride on oesophageal pH monitoring and symptoms in children with gastro-oesophageal reflux disease.

The effect of cisapride on oesophageal pH monitoring and symptoms was studied in seven children with gastro-oesophageal reflux disease. They were treated with cisapride in a dose of 0.2 mg/kg/ very six hours. The comparative analysis of oesophageal pH monitoring between before and after the six-week treatment period showed significant improvements in the percentage of time pH<4, the number of reflex episodes (P=0.06). The symptoms, including pneumonia, cyanosis and asthma, were improved in all but one patient. The patients tolerated cisapride without any side effects.