ABSTRACT
PURPOSE: This study set out to evaluate the compliance to, and efficacy of oral supplementation, using a 1.5 kcal/mL or 1 kcal/mL sip feed, in children with mild to moderate malnutrition. METHODS: This was a parallel, randomized, controlled open-label trial in children aged 3 to 6 years with a weight for height Z (WHZ) score <−1 and ≥−3, who were randomized to receive a total of 600 kcal/day from either a 1.5 kcal/mL or a 1.0 kcal/mL pediatric sip feed for 28 days. Assessments included daily study product intake, body weight, tolerance and dietary intake from solid food. RESULTS: Of 110 children recruited, 98 (mean±standard deviation of age 49±7 months) completed the study. Both sip feeds were well tolerated, with high compliance (80±24% and 81±22% of prescribed volume in 1.5 kcal/mL and 1.0 kcal/mL groups respectively, p=0.79). Both study groups gained similar weight during the 28 days intervention period (0.42±0.40 kg in 1.5 kcal/mL group vs. 0.49±0.49 kg in 1.0 kcal/mL group, p=0.43). There were no significant differences between the groups in weight gain and in the change in WHZ score over the intervention period. Dietary analysis at the end of the study did not show replacement of solid food by the oral nutritional supplements. CONCLUSION: In children with mild to moderate malnutrition, both 1.5 kcal/mL and 1 kcal/mL pediatric sip feeds had high compliance and were well tolerated, and were equally effective in promoting weight gain in the 28 days study period.
Subject(s)
Child , Humans , Body Weight , Compliance , Malnutrition , Weight GainABSTRACT
OBJETIVO: Em pacientes hospitalizados, comparar a evolução de variáveis antropométricas e a ocorrência de efeitos adversos relacionados ao consumo de suplementos nutricionais e infusão de nutrição enteral. MÉTODOS: 10 pacientes que recebiam suplementos nutricionais (Grupo SN) e 20 em nutrição enteral (Grupo NE), pareados para o gênero, idade (50 ± 21 vs 49 ± 23 anos) e afecções de base foram submetidos à avaliação antropométrica ao início e término da terapêutica. Diariamente, foi aplicado um questionário semi-estruturado referente às queixas gastrointestinais. Determinaram-se as diferenças estatísticas obtidas entre o início e o final da terapêutica (teste t para amostras dependentes) e entre os grupos de estudo (teste t para amostras independentes). RESULTADOS: A circunferência muscular do braço aumentou nos pacientes do Grupo NE (80 ± 15 vs 85 ± 15 por cento de adequação, p = 0,009) e diminuiu no Grupo SN (96 ± 14 vs 92 ± 14 por cento de adequação, p = 0,04). Náuseas e vômitos foram mais frequentes no Grupo SN (60 vs 10 por cento, p = 0,01) e as queixas relacionadas ao sabor dos produtos ocorreram em 30 por cento dos casos. CONCLUSÃO: Os pacientes que receberam suplementos nutricionais apresentaram maior ocorrência de queixas gastrointestinais e evolução desfavorável dos parâmetros antropométricos. Os dados obtidos no estudo não evidenciam o benefício da suplementação nutricional de rotina em pacientes hospitalizados.
OBJECTIVE: To compare the evolution of anthropometric variables and the occurrence of adverse effects related to the ingestion of nutritional food supplements and enteral diet administration in hospitalized patients. METHODS: The study was performed in the Clinical Medicine wards of the Hospital of the School of Medicine of Ribeirão Preto, USP, with 10 patients receiving nutrition supplements, and 20 patients under enteral nutrition therapy, paired by gender, age (50 ± 21 vs 49 ± 23 years) and basic afflictions. All were volunteers submitted to anthropometric evaluation at the beginning and end of nutritional therapy, utilizing standard techniques. A semi-structured questionnaire was applied daily referring to gastrointestinal complaints. Statistical differences between onset and final results (t-test for dependent samples) and between-group differences (t-test for independent samples) were estimated. RESULTS: Arm muscle circumference increased in patients receiving enteral nutrition therapy (80 ± 15 vs 85 ± 15 percent adequacy, p = 0.009) and decreased in those receiving nutritional supplements (96 ± 14 vs 92 ± 14 percent adequacy, p = 0.04). Nausea and vomiting were more frequent in the latter (60 vs 10 percent, p = 0.01); complaints about taste of the products were reported by 30 percent of the cases. CONCLUSION: Patients who received oral nutrition supplements reported gastrointestinal complaints and had a less favorable anthropometric evolution. Study data did not disclose the benefit of routine nutrition supplements for hospitalized patients.