Comparison of Weight for Height and BMI for Age for Estimating Overnutrition Burden in Under-Five Populations With High Stunting Prevalence

Background: Overnourished under-five children are anthropometrically classified as either being at possible risk of overweight, overweight or obese and defined so, when either weight for height or body mass index for age (BMI-for-age) are >1SD to 2SD, >2SD to 3SD and >3SD, respectively of the analogous World Health Organization standards. Aim: To compare weight for height and BMI for age definitions for quantifying overnutrition burden. Methods: Theoretical consequences of ignoring age were evaluated by comparing, at varying height for age z-scores, the age- and sex-specific cutoffs of BMI that would define overnutrition with these two metrics. Overnutrition prevalence was then compared in simulated populations (short, intermediate and tall) and real-life datasets from India. Results: In short (-2SD) children, the BMI cutoffs with weight for height criteria were lower in comparison to BMI for age till 7-8 months, but higher at later ages. In National Family Health Survey-4, India dataset (short population), overnutrition (>1SD) prevalence with weight for height was higher from 0-0.5 years (exclusive breastfeeding age), but lower at subsequent ages. The prevalence difference (weight for height - BMI for age) in 0.5-5 years was -2.26% (6.57% vs 8.83%); this attenuated in 0-5 years (-1.55%; 7.23% vs 8.78%). The discrepancy was maximal for stunted children and was lower in girls. A similar pattern, of lower magnitude, was observed for overweight (>2SD) comparison. In intermediate and tall populations, there were no meaningful differences. Conclusion: The two definitions produce cutoffs, and hence estimates of overnutrition, that differ with the age, sex, and height of under-five children. The relative invariance, with age and height, of BMI for age, favors its use.

INTRA-FAMILY DIFFERENCES IN NUTRITIONAL STATUS BETWEEN PRE-SCHOOL AND SCHOOL AGE CHILDREN

Currently under- and over-nutrition are public health problems in Indian children. A community-based study in 3249 children was undertaken to assess the magnitude of intra-family differences in nutritional status between pre-school and school age children from urban low middle income families. Length/height and weight were measured; nutritional status was computed using WHO Anthro and Anthro Plus software. One-fourth of children were stunted, 1/5th underweight, 1/10th wasted and less than 5% were overweight. Prevalence of stunting, underweight and wasting was higher in children whose elder siblings were stunted, underweight or wasted. However, majority of the younger siblings of under-nourished elder siblings were normally nourished; majority of the elder siblings of undernourished younger sibling were normally nourished. In view of this, it is essential to screen all children, identify those who are under- or overnourished using BMI-for-age and provide appropriate interventions.

Malnutrición por exceso en niños de 5 a 10 años y su asociación con el estado nutricional pre y gestacional, lactancia materna y patología materna

La malnutrición por exceso es un problema de salud pública relevante, con origen multifactorial y factores asociados como el estado nutricional pregestacional (ENP), durante y post gestación, ganancia excesiva de peso (EGP) gestacional y duración de la lactancia materna. El objetivo del estudio fue evaluar la malnutrición por exceso en niños de 5 a 10 años y su asociación con el estado nutricional pre y gestacional, lactancia materna exclusiva (LME) y patologías maternas. Se realizó un estudio con 213 niños y niñas estudiantes de 5 a 10 años. Los datos biosociodemográficos se obtuvieron mediante entrevistas con las madres y datos maternos previos y el embarazo con el carné de control. El estimó estado nutricional se estimó con z-score del peso para la talla e IMC/E, según sexo. Para los análisis estadísticos se usó el software STATA 15.0. El 56% de los estudiantes tuvo malnutrición por exceso. Un 53,1% de las madres presentó malnutrición por exceso previo al embarazo que aumentó a 74,6% post gestación. El 71,4% de los niños tuvo una LME ≥6 meses. Se relacionó estadísticamente la edad materna ≥35 años (p= 0,044) y la malnutrición por exceso pregestacional (p= 0,014). La edad materna ≥35 años aumentó el riesgo de malnutrición por exceso casi dos veces (OR= 1,78; IC: 1,029-3,046), al igual que el ENP (OR= 2,11; IC: 1,193-3,693) y en patologías maternas (OR= 1,41; IC: 1, 073-2,694). En conclusión, los niños preescolares de 5 a 10 años con factores de edad materna ≥35, ENP y patologías maternas tuvieron entre 1,4 y 2,11 veces más riesgo de presentar malnutrición por exceso comparado con aquellos niños sin estos factores.

Overnutrition is a relevant public health problem with a multifactorial origin. Associated factors include maternal nutritional status before, during, and after gestation, excessive gestational weight gain, and breastfeeding duration. The objective of the study was to evaluate the association between overnutrition in children aged 5-10 years and pre- and gestational nutritional status, exclusive breastfeeding, and maternal pathologies. The study consisted of 213 schoolchildren aged 5-10 years. Bio-socio-demographic data were obtained through interviews with mothers, previous maternal data and pregnancy follow-up records. Nutritional status was measured using weight-for-height and BMI z-score by age and sex. The STATA 15.0 software was used for statistical analysis. A total of 56% of the schoolchildren had overnutrition. Meanwhile, 53.1% of the mothers demonstrated pre-pregnancy overnutrition, which increased to 74.6% post-pregnancy. It was found that 71.4% of schoolchildren had experienced exclusive breastfeeding ≥6 months. Maternal age ≥35 years (p= 0.044) and pre-gestational nutritional status (p= 0.014) were statistically related. Maternal age ≥35 years increased overnutrition by almost two-fold (OR= 1.78; IC: 1.029-3.046), as did pre-gestational nutritional status (OR= 2.11; IC: 1.193-3.693) and maternal pathologies (OR= 1.41; IC: 1.073-2.694). In conclusion, schoolchildren aged 5-10 years with mothers ≥35 years of age, who had overnutrition in the pre-gestational period, and a pathology were 1.4 to 2.44 times more at risk of developing overnutrition than children without these factors.

Prevalence of Overnutrition using Body Mass Index in Comparison with Bioelectrical Impedance Analysis among Children and Adolescents in Benin, Nigeria

Aim: To compare the prevalence of overweight and obesity among school children in Egor Local Government Area (LGA) using body mass index (BMI) and bioelectricial impedance analysis (BIA) and determine the ability of body mass index (BMI) to predict body fat mass as measured by bioelectricial impedance analysis (BIA). Study Design: This was a cross sectional study conducted in Egor Local Government Area of Edo State of Nigeria with1067 children aged 6-18 years recruited from private and public schools. Body mass index was calculated as weight in kilograms divided by the square of height in meters while Body fat was estimated by BIA using a Tanita scale. Place and Duration of Study: The study took place in selected private and public primary/secondary schools in Egor LGA of Edo State. The study was conducted over a three-month period from October to December 2017. Methodology: Using multi-stage sampling technique,1067 children aged 6-18 years were recruited from private and public schools in Egor Local Government Area in Benin City, Nigeria. Body fat was estimated by BIA using a Tanita scale, whereas BMI was calculated as weight in kilograms divided by the square of height in meters. Data was analyzed using SPSS version 21. Results: A total of 1067 pupils consisting of 538 (50.4%) males and 529 (49.6%) females were recruited. The overall prevalence of overnutrition by BMI, 13.4% (overweight 9.6% and obesity 3.8%) was comparable to that by BIA which was 12.4% (overweight 5.4% and obesity 6.9%). BMI showed a strong positive correlation with fat mass, and fat mass index especially in females (0.917, 0.907, p < 0.000). Conclusion: The prevalence of overnutrition using BMI and BIA was comparable. The prevalence of obesity is however underestimated with BMI.

Early introduction of exercise prevents insulin resistance in postnatal overfed rats

Early childhood obesity increases the risk of developing metabolic diseases. We examined the early introduction of exercise in small-litter obese-induced rats (SL) on glucose metabolism in the epididymal adipose tissue (AT) and soleus muscle (SM). On day 3 post-birth, pups were divided into groups of ten or three (SL). On day 22, rats were split into sedentary (S and SLS) and exercise (E and SLE) groups. The rats swam three times/week carrying a load for 30 min. In the first week, they swam without a load; in the 2nd week, they carried a load equivalent to 2% of their body weight; from the 3rd week to the final week, they carried a 5% body load. At 85 days of age, an insulin tolerance test was performed in some rats. At 90 days of age, rats were killed, and blood was harvested for plasma glucose, cholesterol, and triacylglycerol measurements. Mesenteric, epididymal, retroperitoneal, and brown adipose tissues were removed and weighed. SM and AT were incubated in the Krebs-Ringer bicarbonate buffer, 5.5 mM glucose for 1 h with or without 10 mU/mL insulin. Comparison between the groups was performed by 3-way ANOVA followed by the Tukey post-hoc test. Sedentary, overfed rats had greater body mass, more visceral fat, lower lactate production, and insulin resistance. Early introduction of exercise reduced plasma cholesterol and contained the deposition of white adipose tissue and insulin resistance. In conclusion, the early introduction of exercise prevents the effects of obesity on glucose metabolism in adulthood in this rat model.

Addressing the Double Burden of Malnutrition using the Life Course Perspective

@#The double burden of malnutrition refers to the coexistence of undernutrition which is typically characterised by stunting and wasting, alongside overnutrition at all levels of the population. The objective of this article is to review the current issues in addressing the double burden of malnutrition using the life course approach. Studies addressing life course approach in DBM were identified through PubMed & EMBASE databases. Relevant studies were critically appraised. The challenges, opportunities and way forward in addressing DBM through the life course concept were discussed. The review showed that the DBM dilemma could be addressed via a holistic perspective through a life course concept as nutrition plays an important role in influencing health from pre-conception to old age. The life course concept proposes that environmental exposures, including biological, physical, social, and behavioral factors, including life experiences, throughout life, influence health outcomes in current generations and their offspring.

Hábitos alimentarios y estado nutricional de niños y niñas que asisten a las Escuelas Deportivas Integrales del Instituto Nacional de Deporte, Región de Ñuble / Eating habits and nutritional status of children attending the Integral Sports Schools of the National Sports Institute, Ñuble Region, Chile

RESUMEN La malnutrición por exceso se ha convertido en un problema de salud pública a través de todo el ciclo vital. El objetivo del estudio fue analizar los hábitos alimentarios y el estado nutricional de niños y niñas que asisten a las Escuelas Deportivas Integrales (EDI) del Instituto Nacional de Deporte en la comuna de Chillán. Se realizó evaluación antropométrica y aplicación de encuesta sobre hábitos alimentarios, que permitía medir alimentos consumidos de manera diaria, semanal y mensual de: frutas, verduras, lácteos, agua, carne, pescado, legumbres, golosinas dulces y saladas, productos fritos, comida rápida y embutidos. En los resultados, se confirma una alta prevalencia de malnutrición por exceso (58,7%). Para el cumplimiento de las Guías Alimentarias Basadas en Alimentos (GABAS) para la población chilena, se observó sólo un 59,2% en frutas, 71,4% para verduras, 13,8% en pescado, 39,3% en legumbres y 66,3% en lácteos. Diariamente, más del 65% consume golosinas dulces y/o saladas. Semanalmente, la comida rápida y productos fritos se ingieren en un 66% y 79% respectivamente. Se sugiere la necesidad de realizar intervenciones multidisciplinarias de prevención y promoción de la salud, orientadas a mejorar estilos de vida saludables en la población infantil y así contribuir a disminuir los índices de morbilidad infantil.

ABSTRACT Over nutrition has become a public health problem over the life cycle. The objective of the study was to analyze the eating habits and nutritional status of children attending the Integral Sports Schools (ISS) of the National Sports Institute in Chillán, Chile. An anthropometric evaluation was performed; an eating habits survey, which measured the consumption of fruit, vegetables, dairy products, water, meat, fish, legumes, sweet and salty treats, fried products, junk food, and cold meats on a daily, weekly, and monthly basis was completed. Results confirmed a high prevalence of overnutrition (58.7%). Complying with Food Based Dietary Guidelines for the Chilean Population, values were 59.2% for fruit, 71.4% for vegetables, 13.8% for fish, 39.3% for legumes, and 66.3% for dairy products. More than 65% of the children ate sweet and/or salty treats on a daily basis. Weekly intake of junk food and fried products was 66% and 79%, respectively. Multidisciplinary prevention and health promotion interventions are required to improve healthy lifestyles in children and thus contribute to reducing child morbidity rates.

Double burden of malnutrition among mother-child DYADS in urban poor settings in India

Introduction: Low-and middle-income countries are undergoing nutrition transition wherein presence of under and over-nutrition in the same household is increasing. Aims & Objectives: This study explored the coexistence of under and over-nutrition among mother-child dyads in an urban poor setting in India. Material & Methods: Data was collected from 225 dyads in urban poor settings of Delhi. Anthropometric measurements (weight, height, waist-circumference, hip circumference in mothers and weight, height, MUAC in children) were taken from a random sample of mothers aged >18 years with children aged 3-5 years. Prevalence of underweight, stunting, wasting and overweight/obesity were determined in children, while corresponding proportions of underweight and overweight/obesity were determined in mothers, based on BMI and waist circumference. Results: Of the 225 children, 19% were stunted, 12% were underweight, 4.8% were wasted, while 20% were overweight/obese. Among their mothers, 8.4% were underweight, 20% were overweight/obese and 23% had waist circumference > 88cm. A large proportion of overweight and obese mothers (33% and 30% respectively) had stunted, wasted or underweight children. Among the overweight/obese children, 12% had underweight, and 22% had overweight/obese parentage. Among, all dual burden households, the nutritional status of child correlates with that of mother. Conclusion: One-third mother-child dyads revealed the existence of double burden of malnutrition characterized by high prevalence of undernutrition, stunting and wasting in children, and overweight/obesity in mothers within the same household. It is crucial to understand the pathways to this coexistence, and to test effectiveness of context-specific interventions to curb associated future health risks

El perfil general del excedente nutrimental en México en el periodo 1990-2013: un enfoque a partir del suministro energético de macronutrimentos y grupos de alimentos / General profile of the nutrition surplus in Mexico from 1990-2013: An approach using the energy supplied by macronutrients and food groups

RESUMEN En este texto se analiza la evolución del suministro excesivo de kilocalorías en México desde 1990 a 2013. Para cada año del periodo se estimó el requerimiento de energía y macronutrimentos de la población mexicana y se lo contrastó con el respectivo suministro per cápita para estimar la discrepancia entre requerimiento y suministro. Las discrepancias se analizaron como serie temporal. Así, el excedente energético osciló entre 700 y 800 kcal/día per cápita en todo el periodo y los azúcares-dulcificantes aportaron el mayor suministro energético por encima de su requerimiento. El exceso de lípidos se incrementó de modo intenso y constante principalmente por el aumento de lípidos de carne de aves de corral y cerdo. El exceso aportado por las bebidas alcohólicas tendió a polarizarse en el creciente consumo de cerveza. En suma, a partir de los azúcares-dulcificantes y la carne se tendió a configurar el suministro energético y su respectivo excedente. Esto tiene implicaciones directas en la prevalencia de enfermedades crónicas no transmisibles así como en el uso insostenible de la tierra, el agua y la energía.

ABSTRACT This text analyzes the evolution of the excessive food energy supply in Mexico from 1990 to 2013. For each year, the energy and macronutrient requirements of the Mexican population were estimated and contrasted with the per capita energy supply. Discrepancies between requirement and supply were analyzed as a time series. The energy surplus ranged from 700 to 800 kcal per capita per day throughout the studied period and sugar/sweeteners contributed the highest above-requirement energy supply. Lipids excess increased steadily and intensely, mainly due to lipid increases from poultry and pork. Excess energy from alcoholic beverages tended to be concentrated into growing beer consumption. In summary, the energy supply and the corresponding surplus tended to be made up mainly of sugar/sweeteners and meat. This has direct implications for the prevalence of chronic non-communicable diseases as well as unsustainable use of land, water and energy.

Effects of early postnatal nutrition on adult-onset insulin resistance in Sprague-Dawley rats / 中华围产医学杂志

Objective To explore the effects of early postnatal nutrition on adult-onset insulin resistance by an artificial nutrition intervention during the critical period. Methods On postnatal day 2, Sprague-Dawley rats were assigned randomly to overnutrition (SL), normonutrition (NL) and undernutrition (LL) via artificially adjusting the number of pups nursed per dam. Litter size was adjusted to 3 pups/dam, 10 pups/dam and 20 pups/dam for the SL, NL and LL groups, respectively. There were eight litters for each group. All the pups were nursed by their natural dams and fed with a standard rodent laboratory chow. The pups were weaned on postnatal day 21 and three male pups from each litter were separated. After that, all male rats were housed three per cage and fed standard chow until 16 weeks old. At 3 and 16 weeks, rats were killed after overnight fasting and blood was collected. Liver, gastrocnemius muscle and perirenal and epididymal fat pads were dissected and weighed to calculate relative mass after normalization for body weight. Physiological parameters, biochemical values and insulin resistance status, including serum insulin level, homeostasis model assessment for insulin resistance (HOMA-IR) index and intraperitoneal glucose tolerance test (IPGTT), were dynamically monitored. Analysis of variance was used for statistical analysis. Results (1) Before weaning, the body weights of SL rats were significantly heavier than NL rats after postnatal day 10, and weights of LL rats were significantly lower than NL rats after postnatal day 7. After weaning, body weights of SL rats still remained heavier and weights of LL rats continued to be lower than NL rats (P<0.05). (2) At 3 weeks, the weights of liver and perirenal and epididymal fat pads in SL rats were significantly heavier than NL rats, whereas LL rats were lower than NL rats (P<0.05). At 16 weeks, the weights of liver, epididymal fat pads and gastrocnemius muscle in SL rats were significantly heavier than NL rats. Meanwhile, the weights of all detected tissues in LL rats were lower than the NL group. The weights of epididymal fat pads after normalization for body weight in the SL group were heavier than the NL group (P<0.05). (3) At 3 weeks, the fasting serum glucose level of the SL group was significantly higher than the NL and LL groups [(7.77±1.10) vs (6.33±1.20) and (5.80±1.51) mmol/L, respectively, F=13.217, P<0.01]. At 16 weeks of age, the serum insulin level in SL rats significantly increased compared to NL and LL rats [(0.31±0.11) vs (0.16±0.08) and (0.14±0.11) ng/ml, respectively, F=5.369, P=0.017]. For HOMA-IR evaluation, the index was significantly lower in LL rats compared to NL and LL rats at 3 weeks of age [(0.09±0.01) vs (0.25±0.01) and (0.31±0.05), respectively, F=25.923, P=0.005]. At 16 weeks, the index was significantly elevated in SL rats compared to NL and LL rats [(1.77±0.53) vs (0.84±0.44) and (0.83±0.67), respectively, F=5.765, P=0.015]. Furthermore, IPGTT was performed in all groups at 14 weeks of age. SL rats had significantly higher serum glucose levels at 60 min and a significantly increased area under the curve when compared to NL and LL rats (all P<0.05). (4) Serum from 16 week old SL rats was found to contain significantly higher levels of albumin, triglycerides and free fatty acids compared to NL rats (all P<0.05). Conclusions Early postnatal overnutrition induces persistent overweight and visceral white adipose accumulation in rats, while early postnatal undernutrition show the opposite effects. Early postnatal overnutrition may lead to adult-onset insulin resistance in rats. Avoiding overnutrition during the early postnatal period, a critical window for growth and development, may prevent or decrease later metabolic risks.

Percepción de condicionantes del comportamiento alimentario en estudiantes universitarios con malnutrición por exceso / Perception of determining factors in the dietary behavior of higher education students with overnutrition

Introducción: la Organización Mundial de la Salud proyectó para el año 2015 que 3.000 millones de adultos en el mundo presentarán malnutrición por exceso. Esta situación debe ser considerada, especialmente en el fortalecimiento de los programas de salud existentes destinados a usuarios con estas patologías. Objetivo: interpretar la percepción de estudiantes universitarios con malnutrición por exceso, de los factores que condicionan su alimentación. Materiales y métodos: utilizando un diseño cualitativo del tipo fenomenológico, se realizan entrevistas semiestructuradas a 16 alumnos pertenecientes a la Universidad Católica de la Santísima Concepción durante el año 2010, que cumplieron con los requisitos de ingreso al estudio y firmaron el consentimiento informado. Resultados: entre las condicionantes que se perciben como influyentes en la alimentación de los estudiantes entrevistados se encuentran la limitada disponibilidad de tiempo durante la vida universitaria; el grupo familiar; los amigos; el alto costo y una reducida oferta de alimentos saludables dentro del establecimiento educacional; situaciones de estrés académico y el lugar de residencia. Conclusiones: a excepción de la familia, las condicionantes de la alimentación identificadas por los entrevistados son interpretadas como desfavorables para mantener una alimentación saludable y un control adecuado del peso corporal.

Introduction: According to the World Health Organization the number of adults presenting overnutrition will reach 3.000 million by the year 2015. This situation must be considered, especially strengthening the existing health programs that aim at people with these pathologies. Objective: The main goal is to interpret the perception of the factors that condition the diet of higher education students with overnutrition. Materials and methods: Through a phenomenological-type study, using a qualitative design, semi-structured interviews were conducted to 16 students that fulfilled the requirements to participate in the study and granted their consent. All of them were at Universidad Católica de la Santísima Concepción during the year 2010. Results: Among the determining factors that have a strong influence on the diet of the interviewed students, it was found the limited period of time that students have between classes; their family; their friends; the elevated price, and the reduced supply of healthy food on campus; academic stress, and their place of residence. Conclusions: With the sole exception of the family, the conditioning factors identified by the interviewed people were considered as unfavorable to maintain a balanced diet and an appropriate control over body weight.

Early postnatal overnutrition results in insulin resistance in adulthood / 中华内分泌代谢杂志

Overnutrition during the early postnatal life,a critical time window for growth and development,may induce metabolic syndrome later in life,including overweight/obesity and insulin resistance.The important target organs of insulin,such as liver,adipose tissue,skeletal muscle,and central nervous systems show insulin resistance.The involved mechanisms include abnormality of insulin signal pathway,increment of free fatty acid and some adipocytokines,oxidative stress,maladjustment of orexigenic and anorexigenic neuron,modifications of the hypothalamic-pituitary-adrenal glucocorticoid axis as well as epigenetic,etc.Hence,overnutrition should be avoided during the early postnatal life,so as to decrease the risk of developing long-term insulin resistance.

Avaliação do metabolismo ósseo em modelos de plasticidade ontogenética / Evaluation of bone metabolism in models of developmental plasticity

O aumento da prevalência da obesidade e osteoporose, bem como a identificação de mecanismos comuns que ligam a osteogênese e a adipogênese, sugerem que a obesidade e osteoporose podem ser distúrbios relacionados, e além disso, ambos podem ter suas origens no início da vida. Em 3 modelos diferentes de plasticidade ontogenética foi observado obesidade na vida adulta. Sendo assim, o objetivo deste trabalho foi investigar o impacto desses 3 modelos, o desmame precoce mecânico (DPM) e o farmacológico (DPF), e a supernutrição neonatal (SN) no tecido ósseo da prole durante o desenvolvimento. Para tanto, 2 experimentos foram realizados. No experimento 1, ratas lactantes foram divididas em 3 grupos: controle - os filhotes tiveram livre acesso ao leite durante toda a lactação; DPM - as mães foram envolvidas com uma atadura nos últimos 3 dias de lactação; DPF - as mães foram tratadas com bromocriptina (0,5 mg/duas vezes/dia) 3 dias antes do desmame padrão. No experimento 2, o tamanho da ninhada foi reduzido para 3 filhotes machos no 3o dia de lactação até o desmame (SN); o grupo controle permaneceu com 10 filhotes durante toda a lactação. Realizou-se absorciometria de raios-x de dupla energia, tomografia computadorizada, microtomografia computadorizada, teste biomecânico e análises séricas. Os dados foram considerados significativos quando P<0,05. No experimento 1, ao desmame, os filhotes DPM e DPF apresentaram menor massa corporal, massa gorda, densidade mineral óssea total (DMO), conteúdo mineral ósseo total (CMO), área óssea e osteocalcina sérica, e maior telopeptídeo carboxi-terminal do colágeno tipo I (CTX-I). O cálcio ionizado sérico foi menor apenas na prole DPM, a 25-hidroxivitamina D (25(OH)D) foi maior e o PTH menor apenas na prole DPF. Aos 180 dias, as proles DPM e DPF apresentaram maior massa corporal, maior massa de gordura visceral, hiperleptinemia, maior 25(OH)D e menor CTX-I...

Nutritional changes during critical developmental periods are associated with chronic diseases in adulthood, a phenomenon known as developmental plasticity. Osteogenesis and adipogenesis have common mechanisms. In 3 different models of developmental plasticity, we observed programming for obesity. Thus, the aim of this study was to investigate the impact of these 3 models, mechanical early weaning (MEW), pharmacological early weaning (PEW), and early overnutrition (EO) upon offspring’s bone tissue during development. Thus, the present study was divided into two experiments. In experiment 1, lactating rats were separated into 3 groups: control - pups had free access to milk; MEW - dams were involved with a bandage interrupting lactation in the last 3 days; PEW - dams were pharmacologically treated to block prolactin (0.5 mg bromocryptine/twice a day) 3 days before standard weaning. In experiment 2, litter size was adjusted to 3 male rats per litter (EO). Litter containing 10 pups per mother was control. Bone tissue was evaluated by dual-energy X-ray absorptiometry, computed tomography, microcomputed tomography, biomechanical tests and serum analyses. Data significant had P<0.05. In experiment 1, at weaning, MEW and PEW pups presented lower body weight, total body fat, total bone mineral density (BMD), total bone mineral content (BMC), bone area, serum osteocalcin and higher C-terminal cross-linked telopeptide of type I collagen (CTX-I). However, serum ionized calcium was lower only in MEW pups, 25-hydroxyvitamin D was higher and PTH was lower only in PEW pups. In adulthood, MEW and PEW groups presented higher body weight, visceral fat mass, 25-hydroxivitamin D, hyperleptinemia and lower CTX-I...

Mapping the nutrition transition in Peru: evidence for decentralized nutrition policies / Cartografía de la transición nutricional en el Perú: datos que avalan la necesidad de políticas nutricionales descentralizadas

The study objectives were to map the different stages of the nutrition transition for each departmentwithin Peru, and to determine the nutrition policy needs for each geographic areabased on their current stage in the nutrition transition. Results show that most of the countryis suffering from a double-burden of malnutrition, with high rates of stunting among childrenless than 5 years of age and high rates of overweight and obesity among women of reproductiveage. Currently, Peru has only country-wide nutrition policies, administered by the Ministryof Health, that are primarily focused on stunting prevention. This study argues for the need tohave decentralized nutrition policies that vary according to what type of malnutrition is beingexperienced in each geographic area.

Los objetivos de este estudio consistían en trazar un mapa por departamentos yetapas de la transición nutricional en el Perú y determinar las políticas nutricionalesnecesarias en las distintas zonas geográficas en función de sus etapas en la transición.Los resultados demuestran que la mayor parte del país está sufriendo la llamada“doble carga de la malnutrición”, en la que coexisten tasas elevadas de desnutricióncrónica entre los menores de 5 años y tasas elevadas de sobrepeso y obesidad en lasmujeres en edad fecunda. En el Perú actual, las políticas nutricionales, gestionadaspor el Ministerio de Salud, están centralizadas y su prioridad es prevenir la detencióndel crecimiento. Este estudio aboga por la necesidad de contar con políticas nutricionalesdescentralizadas que varíen en función del tipo de malnutrición que se estépadeciendo en cada zona geográfica.

Efeito da superalimentação na lactação sobre a regulação da composição corporal, homeostase glicêmica, perfil lipídico, função tireoideana e sinalização da leptina em ratos jovens e adultos / Effect of overfeeding during lactation on the regulation of body composition, glucose homeostasis, lipid profile, thyroid function and leptin signaling in young and adult rats

Ratos criados em ninhadas reduzidas são utilizados como modelo experimental para o estudo dos efeitos imediatos e tardios da superalimentação pós-natal. Nesse trabalho estudamos algumas alterações decorrentes do sobrepeso no início da vida em animais jovens e adultos. Avaliamos a composição corporal e as concentrações séricas de glicose, insulina, leptina, adiponectina, hormônios tireoideanos e TSH, além do perfil lipídico e das proteínas totais séricas e suas frações. Também analisamos a tolerância à glicose, atividades D1 e GPDm em fígado e as proteínas da cascata de sinalização da leptina (Ob-R, JAK2, STAT3, p-STAT3 e SOCS3) no eixo hipotálamo-hipófise-tireóide (HHT). Para induzir a superalimentação, as ninhadas foram ajustadas para 3 filhotes machos/rata lactante a partir do 3º dia de lactação (grupo S). O controle (grupo C) permaneceu com a ninhada completa (dez filhotes/rata lactante) até o desmame (21º dia). O consumo alimentar foi maior no grupo S desde o desmame até os 180 dias, caracterizando uma hiperfagia persistente. A massa corporal, acompanhada durante todo o crescimento, foi maior no grupo S aos 21 dias, mantendo-se assim até os 180 dias de idade. As gorduras visceral e total foram maiores nos animais superalimentados tanto ao desmame como na vida adulta. Em relação à gordura subcutânea, observamos aumento somente nos animais jovens. A massa protéica corporal e o HDL-c sérico foram maiores aos 21 dias, embora menores aos 180 dias de idade. Ao desmame, os animais do grupo S apresentaram aumento nas proteínas totais, albumina e globulina. Já na vida adulta, estes animais apresentaram menor albuminemia e maior globulinemia, sem alterar as proteínas totais. Verificamos maiores concentrações séricas de glicose, insulina, leptina, T3, T4 e TSH, sem alteração na adiponectina no grupo S aos 21 dias. Os animais jovens do grupo S apresentaram maior atividade D1 e menor atividade GPDm no fígado. Aos 180 dias, detectamos somente menor T3 e T4 séricos...

Rats raised in small litters have proven to be an appropriated experimental model to study the consequences of overnutrition during the critical perinatal period. We aimed to study some alterations induced by overweight in early life of young and adult animals. We analyzed the body composition, the serum levels of glucose, insulin, leptin, adiponectin, thyroid hormones and TSH, as well as, the lipid profile and the total proteins and its fractions. We also analyzed the glucose tolerance test in adulthood, liver D1 and mGPD activities and the proteins of leptin signaling pathway (Ob-R, JAK2, STAT3, p-STAT3 e SOCS3) in the HPT axis. To induce early postnatal overnutrition, the litter size was reduced to 3 pups male/litter (small litter-SL group). In control group (normal litter-NL group), the size litter was adjusted to 10 pups/litter until to weaning (21st day). The food intake was higher in the SL group since weaning until adulthood, characterizing the hyperphagia. The body weight of the SL group was higher at 21 days-old and 180 days-old compared to NL group. The visceral and total fat mass were hither in both young and adult SL animals. The protein mass and serum HDL-c were higher at 21 days and lower at 180 days old. The young SL animal presented higher total proteins, albumin and globulin, while the adult SL animals presented lower albumin, higher globulin, with no change in the total proteins. At 21 days-old, we verifies in SL group higher levels of glucose, insulin, leptin, thyroid hormones and TSH, with no change in serum adiponectin. The SL young animals presented higher D1 and lower mGPD activities in liver. At 180 days-old, we only observed lower T3 and T4 levels, and glucose intolerance 2 hours after glucose administration. About leptin signaling pathway in hypothalamus, we observed lower JAK2, lower p-STAT3 and higher SOCS3 expression in the of adult SL animals. In pituitary, the SL group presented higher Ob-R, JAK2 and P-STAT3 content...