1.
Journal of International Oncology
;
(12): 489-492, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-426767
ABSTRACT
The overexpression of P-glycoprotein(P-gp)and its coding gene mdrl is regarded as the classic mechanism of muhidrug resistance(MDR).Recent studies find that pregnane X receptor(PXR)can mediate the expression of P-gp.It is confirmed that PXR can also inhibit apoptosis of tumor cells.Therefore,preventing the activation of PXR specifically may be a new method to prevent MDR.