ABSTRACT
Background: Studies claim that anemia at any time in life can hamper the metabolic processes and subsequently affect the cognitive and behavioral domain of an individual. Late-adolescent girls are one of the most vulnerable groups due to commencement of menstrual cycles, hormonal changes, nutritional deficits etc. It is also the time period where adolescents enter their professional careers in our country where cognition forms the basis of all the learning. This study was focused on seeing whether anemia affects the P300 wave which is a cognitive evoked potential. Methods: 74 girls of first and second year MBBS were chosen for this study. They were divided into two groups on basis of hemoglobin estimation by cyanmethemoglobin method. A comparative study was done of P300 latency and P300 amplitude between the two groups. Results: Comparison between the anemic group to the control group revealed: Latency of P300 was significantly delayed in the anemic group and amplitude was significantly higher in the control group. Conclusion: The results suggested a better cognitive performance of those having normal hemoglobin levels.
ABSTRACT
@#Objective To observe the change of the latency and amplitude of auditory-evoked potential P300 after oxygen inhalation.Methods 27 healthy male academicians were included. They were divided into control group (n=12) and experiment group (n=15) according to the random numerical table, and they were blinded about groups. All subjects in the experiment group inhaled pure oxygen while air in the control group through a mask for 60 minutes. EEG was recorded when an auditory Oddball paradigm was performed during following 4 periods: before oxygen inhalation (pre0), inhale oxygen (air in control) for 20 minutes (Oxy20) and 50 minutes (Oxy50), 30 minutes after oxygen inhaled (post30). The latency and amplitude of P300 from target stimuli were calculated. Results The latency of P300 was longer at Oxy20 as (358.58±15.32) ms, Oxy50 as (353.42±9.41) ms and post30 as (354.10±10.42) ms than at pre0 as (335.91±15.40) ms in the control group (P<0.01). The latency of P300 was shorter at Oxy50 as (319.17±14.34) ms, and post30 as (318.50±13.87) ms than at pre0 as (332.98±14.63) ms in the experiment group (P<0.05). The latency was shorter in the experiment group than in the control group at Oxy20,Oxy50 and post30 (P<0.01). The amplitudes were stable in the control group (P<0.05). The amplitude was lower at post30 as (2.41±0.64) μV than at pre0 as (5.49±0.89) μV in the experiment group (P<0.05). Conclusion Oxygen inhalation shortens the latency of P300, and decreases the amplitude in the similar trend with the prolongation of oxygen inhalation.