Effects of " acupuncture on cerebral blood flow in patients with high risk of cerebral ischemic stroke based on ASL and PWI technique / 中国针灸

OBJECTIVE@#To observe the effects of "" acupuncture on cerebral blood flow in high-risk patients of cerebral ischemic stroke based on arterial spin labeling (ASL) and perfusion-weighted imaging (PWI), and to evaluate the clinical efficacy.@*METHODS@#A total of 180 patients with transient ischemic attacks (TIA) / minor ischemic stroke (MIS) were randomly divided into an acupuncture A group, an acupuncture B group and a medication group, 60 cases in each group. The patients in the acupuncture A group were treated with "" acupuncture at Baihui (GV 20), Fengfu (GV 16), Yamen (GV 15), Dazhui (GV 14), Shenzhu (GV 12), Zhiyang (GV 9), Mingmen (GV 4), Yaoyangguan (GV 3) and Jingjiaji (EX-B 2), once a day; the patients in the acupuncture B group were treated with identical acupoints but was given once every other day; the patients in the medication group were treated with oral administration of nimodipine tablets, 30 mg, three times daily. All the three groups were treated for four weeks. ASL and PWI, including relative cerebral blood volume (rCBV), relative cerebral blood flow (rCBF), relative mean transit time (rMTT) and relative time to peak (rTTP), were conducted before and after treatment; the changes of the test indexes were compared before and after treatment. The clinical efficacy of the three groups was compared.@*RESULTS@#Compared before treatment, the numbers of ASL normal perfusion in the 3 groups were significantly increased after treatment (all 0.05). Compared before treatment, rCBV and rCBF in the 3 groups were significantly increased after treatment (all 0.05). The total effective rate was 88.3% (53/60) in the acupuncture A group, 73.3% (44/60) in the acupuncture B group and 90.0% (54/60) in the medication group; the total effective rate in the acupuncture A group was superior to that in the acupuncture B group (0.05).@*CONCLUSION@#"" acupuncture could effectively improve the hypoperfusion of cerebral blood flow in patients with high risk of cerebral ischemic stroke, reduce the incidence of severe CIS; acupuncture for once a day is better than once every other day.

Differentiation between Glioblastoma and Primary Central Nervous System Lymphoma Using Dynamic Susceptibility Contrast-Enhanced Perfusion MR Imaging: Comparison Study of the Manual versus Semiautomatic Segmentation Method

BACKGROUND: Normalized cerebral blood volume (nCBV) can be measured using manual or semiautomatic segmentation method. However, the difference in diagnostic performance on brain tumor differentiation between differently measured nCBV has not been evaluated. PURPOSE: To compare the diagnostic performance of manually obtained nCBV to that of semiautomatically obtained nCBV on glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL) differentiation. MATERIALS AND METHODS: Histopathologically confirmed forty GBM and eleven PCNSL patients underwent 3T MR imaging with dynamic susceptibility contrast-enhanced perfusion MR imaging before any treatment or biopsy. Based on the contrast-enhanced T1-weighted imaging, the mean nCBV (mCBV) was measured using the manual method (manual mCBV), random regions of interest (ROIs) placement by the observer, or the semiautomatic segmentation method (semiautomatic mCBV). The volume of enhancing portion of the tumor was also measured during semiautomatic segmentation process. T-test, ROC curve analysis, Fisher's exact test and multivariate regression analysis were performed to compare the value and evaluate the diagnostic performance of each parameter. RESULTS: GBM showed a higher enhancing volume (P = 0.0307), a higher manual mCBV (P = 0.018) and a higher semiautomatic mCBV (P = 0.0111) than that of the PCNSL. Semiautomatic mCBV had the highest value (0.815) for the area under the curve (AUC), however, the AUCs of the three parameters were not significantly different from each other. The semiautomatic mCBV was the best independent predictor for the GBM and PCNSL differential diagnosis according to the stepwise multiple regression analysis. CONCLUSION: We found that the semiautomatic mCBV could be a better predictor than the manual mCBV for the GBM and PCNSL differentiation. We believe that the semiautomatic segmentation method can contribute to the advancement of perfusion based brain tumor evaluation.

Propriedades psicométricas das escalas de bem-estar: PWI, SWLS, BMSLSS e CAS / Psychometric properties of the well-being scales: PWI, SWLS, BMSLSS and CAS / Propiedades psicométricas de las escalas de bienestar: PWI, SWLS, BMSLSS y CAS

Este artigo tem como objetivo verificar as propriedades psicométricas dos instrumentos de bem-estar: Personal Wellbeing Index (PWI), Satisfaction With Life Scale (SWLS), Brief Multidimensional Students’ Life Satisfaction Scale (BMSLSS) e Core Affects Scale (CAS) em uma amostra de adolescentes e adultos. Participaram deste estudo 543 adolescentes com idades entre 12 e 16 anos (68,3% meninas) e seus respectivos pais, com idade média aproximada de 44 anos (DP=6,56), totalizando 1086 participantes. Os resultados indicam que o PWI e as escalas SWLS, BMSLSS e CAS apresentam, no geral, bons índices de ajuste quando da realização da análise fatorial (exploratória e confirmatória) para a amostra de adolescentes e de pais, considerando-se o sexo e a idade. A verificação das propriedades psicométricas de medidas cognitivas e afetivas de bem-estar para uso no contexto brasileiro é fundamental para o desenvolvimento da área, assim como para propostas de intervenções baseadas nessas medidas...

This paper aims to examine the psychometric properties of the well-being instruments: Personal Wellbeing Index (PWI), Satisfaction With Life Scale (SWLS), Brief Multidimensional Students’ Life Satisfaction Scale (BMSLSS) and Core Affects Scale (CAS). Participants were 543 adolescents aged between 12 and 16 years (68.3% girls) and their respective parents with an average age of approximately 44 years (SD=6.56), with a total of 1,086 participants. The main results show that the scales SWLS, PWI, BMSLSS and CAS have good overall fit indices when performing factor analysis (exploratory and confirmatory) for the sample of adolescents and parents considering age and gender. The verification of the psychometric properties of cognitive and affective measures of well-being for its use in the Brazilian context is critical to the development of the area, as well as to interventions proposed based on these measures...

El objetivo de este artículo es verificar las propiedades psicométricas de los instrumentos de bienestar: Personal Wellbeing Index (PWI), Satisfaction With Life Scale (SWLS), Brief Multidimensional Students’ Life Satisfaction Scale (BMSLSS) e Core Affects Scale (CAS) en una muestra de adolescentes y adultos. Participaron 543 adolescentes con edades entre 12 y 16 años (68,3% niñas) y sus respectivos padres, con edad media aproximada de 44 años (DT=6,56), con un total 1086 participantes. Los resultados indican que el PWI y las escalas SWLS, BMSLSS y CAS presentan, en general, buenos índices de ajuste al realizar el análisis factorial (exploratorio y confirmatorio) para la muestra de adolescentes y de padres, considerándose el género y la edad. La verificación de las propiedades psicométricas de las medidas cognitivas y afectivas del bienestar para su uso en el contexto brasileño es fundamental para el desarrollo de la área de estudio, así como para las intervenciones propuestas basadas en estas medidas...

Satisfacción escolar y bienestar subjetivo en la adolescencia: poniendo a prueba indicadores para su medición comparativa en Brasil, Chile y España / Subjective well-being and school satisfaction in adolescence: putting indicators for their measurement to the test in Brazil, Chile and Spain

En este estudio se analiza la comparabilidad interlingüística e intercultural del bienestar subjetivo y la satisfacción escolar como componente de dicho bienestar durante la adolescencia, a partir de tres muestras, una de Brasil (n = 1588), una de Chile (n = 843) y una de España (n = 2900), de 12-16 años de edad. Se adoptan como indicadores de bienestar subjetivo dos versiones del personal wellbeing index (PWI) de Cummins, Eckersley, van Pallant, Vugt y Misajon (2003), que lo evalúan por ámbitos, y una escala de ítem único sobre satisfacción general con la vida (overall life satisfaction [OLS]), y como indicadores subjetivos de satisfacción escolar, los seis ítems de satisfacción con distintos aspectos de la vida escolar utilizados por Casas, Baltatescu, Bertrán, González y Hatos (2013). Del PWI se utiliza la versión original (PWI7) y una versión ampliada con diez ítems (PWI10). Ambas versiones del PWI muestran un buen ajuste en los análisis factoriales confirmatorios realizados con las tres muestras agregadas. Mediante análisis de regresión múltiple y modelos de ecuaciones estructurales (MEE), se consideran y se discuten distintas opciones para estimar cuál sería el modelo con mejor comparabilidad respecto del bienestar subjetivo entre países al integrar la satisfacción escolar. Del análisis de los resultados, se aprecia que dos de los MEE multigrupo, que incluyen los seis ítems relativos a satisfacciones con aspectos de la vida escolar relacionados con una variable latente, que a su vez se relaciona con las variables latentes PWI7 y PWI10, muestran buena comparabilidad entre países. Los análisis de regresión múltiple indican que el indicador sintético de satisfacción con aspectos de la vida escolar que resulta más útil es "satisfacción con tu vida de estudiante". Cuando se incluye este ítem, las consistencias internas tanto del PWI7 como del PWI10 mejoran y los respectivos MEE multigrupo de estas dos escalas psicométricas muestran que varianzas, covarianzas y regresiones resultan comparables entre los tres países, mientras que no son comparables las medias de sus índices generales, probablemente debido a diferentes estilos de respuesta de los adolescentes de cada país.

This paper studies the inter-linguistic and intercultural comparability of subjective wellbeing during adolescence, as well as school satisfaction as a component of this well-being, using samples of 12 to 16-year-old from Brazil (n=1588), Chile (n=843) and Spain (n=2900). As subjective well-being indicators, two versions of the PWI (Cummins, Eckersley, van Pallant, Vugt, and Misajon, 2003) were adopted, one measuring well-being with different life domains, a single-item scale on overall life satisfaction (OLS). The six items on satisfaction with different facets of the school life, used by Casas et al. (2013), were included as subjective indicators of school satisfaction. The original version of the PWI (PWI7) and a longer version with 10 items (PWI10) are used. Both versions show a good fit in Confirmatory Factor Analysis using the pooled sample. Using multiple regressions analysis and Structural Equations Modelling (SEM), different options are considered and analyzed in order to estimate the most appropriate model to compare subjective wellbeing cross-countries, with school satisfaction included. An analysis of the results indicates that two multi-group SEM, which include the six items on satisfaction with different facets of school life related to a latent variable, and also related to latent variables PWI7 and PWI10, respectively, show good comparability between countries. Multiple regression analysis suggests that the most useful synthetic indicator on satisfaction with school life is satisfaction with your life as student. When this item is included in PWI7 or PWI10, internal consistency of each of the scales (PWI8 and PWI11) improves, and the respective multi-group SEM of these two psychometric scales show that variances, covariances and regressions are comparable between the three studied countries. This was not the case with the overall mean indices, which is probably due to the different answering styles of adolescents in each country.

Tumores oligodendrogliales: correlación entre el genotipo tumoral e imágenes de perfusión por RM / Oligodendroglial tumors: correlation between tumor genotype and perfusion magnetic resonance imaging

Objetivo: realizar una evaluación retrospectiva respecto de la correlación entre la técnica de perfusión (PWI) por resonancia magnética (RM), el volumen sanguíneo cerebral relativo (VSCr) y el genotipo tumoral, en pacientes con neoplasias oligodendrogliales grado II. Materiales y métodos: once pacientes (7 hombres y 4 mujeres), con un rango de edad entre los 28 y 64 años, con tumores oligodendrogliales (OD) grado II, fueron estudiados con RM convencional y PWI, con la finalidad de obtener un valor de VSCr. Se realizó el análisis genético en todos los pacientes para evaluar el estado de los cromosomas 1p/19q. Resultados: cinco pacientes con tumores ODs grado II (45%) presentaron un VSCr < 1,75 y ausencia de alteraciones en 1p/19q. Tres pacientes tenían oligoastrocitomas (OA), 2 de ellos con alteraciones en 1p/19q y el restante con 1p/19q intacto. Dos de los pacientes con gliomas mixtos, uno con alteración en 1p/19q y el otro con 1p/19q intacto, presentaron un VSCr> 1,75, mientras que en el paciente restante con glioma mixto y deleción en 1p/19q, el VSCr fue de < 1,75. Dos pacientes con ODs grado II presentaron un VSCr> 1,75, uno con 1p/19q intacto y el restante con deleción en 1p/19q. El último paciente presentó un OD grado II con un VSCr< 1,75 y pérdida de 1p/19q. Conclusiones: aproximadamente el 45% de los pacientes con los cromosomas 1p/19q intactos mostró un VSCr< 1,75, lo que sugiere una neoangiogénesis tumoral limitada. Estos hallazgos podrían ser de utilidad para monitorear respuesta a agentes antiangiogénicos. Los estudios realizados en series mayores podrían proporcionar información valiosa antes de la cirugía y contribuir a un mejor manejo de estos pacientes.

Objective: To perform a retrospective assessment of the correlation between perfusion MR imaging, relative cerebral blood volume (rCBV) and genotype in patients with grade II oligodendroglial neoplasms. Materials and methods: Eleven patients (7 men and 4 women), age range: 28-64 years, with grade II oligodendroglial tumors (OD) were studied using conventional MR and perfusion MR imaging (rCBV). Genetic analysis was carried out in all patients to assess -1p/-19q genotype status. Results: Five patients with grade II oligodendroglial tumors (45%) presented rCBV < 1.75 and intact 1p/19q. Three patients had mixed gliomas, two of them had deletion in 1p/19q, and the other presented intact 1p/19 q. rCBV was > 1.75 in two patients and < 1.75 in the other patient. Two patients with grade II oligodendroglioma had an rCBV > 1.75, one with intact 1p/19q, and the other with deletion. The last patient presented a grade II oligodendroglial tumor with rCBV < 1.75 and 1p/19q loss. Conclusions: Approximately 45% of patients with intact 1p/19q showed rCBV < 1.75, suggesting limited tumor neoangiogenesis. These findings could be important for the antiangiogenic therapy follow-up. Studies in larger series could provide valuable information prior to surgery and contribute to a better management of these patients.

MRI Diagnosis and Differential Diagnosis of Hemangioblastoma of Central Nervous System / 中国医学影像学杂志

Purpose:To discuss the MRI features and differential diagnosis of hemangioblastomas in the central nervous system.Materials and Methods: The MRI features of 22 patients with hemangioblastomas confirmed histopathologically were analyzed retrospectively.Results: In this group there were 50 lesions in 22 patients.Multiple lesions were revealed in 5 cases.The lesions located in the cerebellar hemisphere and vermis ( n = 40),medulla oblongata and spinal cord ( n.= 9 ),cerebral hemisphere ( n = 1).Among the 50 lesions,12 appeared as a large cyst with mural nodule,36 as a solid mass,2 as a simple cyst.Of large cyst with mural nodule lesions,the content of the cyst was hy-pointense signal on T1WI,and hyperintense signal on T2WI.The mural nodules were slightly hypointense signal or isointense signal on Tl WI,and hyperintense signal on T2WI.The solid masses were isointense signal on Tl WI,slightly hyperintense signal and hyperintense signal on T2WI.On contrast enhanced scans,all mural nodules and solid tumors were showed marked homogeneous enhancement.On PWI the mural nodules and solid tumors were demonstrated marked hyperperfusion.Conclusion:Hemangioblastomas have distinctive manifestation,MRI enhanced scans and PWI play an important role in the diagnosis and differential diagnosis of hemangioblastomas.

Difference of Physical Symptoms, PWI and JCQ according to Sasang Constitutions for Industrial Workers

PURPOSE: This study was conducted to analyze industrial workers' stresses from physical symptoms, PWI, JCQ and tasks in classification of Sasang constitutions. METHOD: Data were collected from industrial workers in J Province from May 2003 to June 2003. Questionnaires were distributed and collected on the day of their physical examination. Collected data were analysed through chi2-test. RESULT: Health-related characteristics showed that most of smokers and drinkers were Taeumins and this result was statistically significant. Physical symptoms related to constitutions indicated that GI and neurologic symptoms are significantly more frequent in Soeumin. The percentage of subjects with moderate risk was high in order of Soyangin, Taeumin and Soeumin while the percentage of subjects with high risk was high in order of Soeumin, Taeumin and Soyangin. CONCLUSION: Through this study, Lee Jae Ma's theory was be confirmed compatible with disease characteristics. However, research with more various subjects and variables needs to be made.

A Comparative Study of Mental Health between the Laid-Off and the Employed Worker in the Similar Industry / 대한산업의학회지

OBJECTIVES: This study was conducted to examine the mental health status of the laid off by comparing the unemployed with the employed. METHODS: A survey questionnaire was used to investigate the mental health status of the laidoff in comparison with that of the employed. The study sample consisted of 247 laid-off people formerly employed in A auto factory and 167 employees working in B auto factory. RESULTS: The proportion exercising regularly was 20.2% for the laid-off and 34.8% for the employed and the proportion having regular meals was 10.9% and 50.6%, respectively. In addition, the frequency and amount of alcohol consumption and smoking of the laid-off were higher than those of the employed. Among the laid-off, 69.4% responded that they spent less time in talking to their spouse, and 65.4% also reported reduced sexual activities with their spouse. Because of unemployment, 41.8% of the laid-off experienced conflicts with their children, and 53.5% also perceived that they were stigmatized and treated badly by their neighbors, friends and relatives. Mean IFR in the laid-off was 22.9, which was much higher than the 15.3 recorded in the employed. The mean PWI-SF was 24.2 for the laid-off and 13.0 for the employed, which indicates the lower psychological health status of the laid-off than that of the employed. Age, annual salary, family relationship, regular exercise, regular diets, possibility to return to work and perception of the future were related to mental health status for the laid-off. Stepwise multiple regression analysis showed that the most important factor influencing mental health status for the laid-off was family relationships. CONCLUSIONS: According to the above results, the mental health of the laid-off is worse than that of the employed. Based on this study, a follow-up study focusing on the mental health status of the reemployed to the same factory, is needed to understand the direct mental health effect on the laid-off.

Measurement of Regional Cerebral Blood Volume in Normal Rabbits on Perfusion-weighted MR Image

PURPOSE: To evaluate the usefulness of cerebral blood flow measurement applied to perfusion weighted image with short-scan time single shot gradient echo-planar technique in measuring cerebral blood volume(rCBV) of normal rabbits. MATERIALS AND METHODS: With 2.1-3.6 kg weighted rabbits, image is acquired when they are in supine position in children positioner. Perfusion weighted image is acquired to 44 seconds per 1 second successively. After 4 seconds later, Gd-DTPA 2ml are injected into int. jugular vein with 2 ml per second and normal saline is also injected after that. Same technique is applied 2 times per 30 minites in same rabbit. After Image is obtained in two part of cerebral cortex at vertex, convexity, in one of basal ganglia with choosing about 3-5mm2 areas. Curve of signal intensity changes in time sequence is drawn. After this images are transmitted by PC and software IDL, regional cerebral blood volume is measured with imaging processing program made by us. RESULTS: With 22 of 24 rabbits, satisfactory 1-2 signal intensity versus time curve is made. Cerebral blood capacity and contrast media stay time (ST) is measured in two cerebral cortex and basal ganglia refering in parietal cerebral cortex. Mean focal cerebral blood flow capacity ratio in cortex was 0.97+/-0.35 and in basal ganglia, 0.99+/-0.37, mean contrast media stay time in cortex was 9.83+/-1.63 sec and in basal ganglia, 9.42+/-1.14 sec, but there was no statistically significant difference between two areas (p=0.05). CONCLUSION: In cerebral cortex and basal ganglia, there is no difference in mean focal blood volume and mean contrast stay time. Therefore, PWI is useful in cerebral blood flow and early diagnosis, prognosis of cerebral ischemic disease. Hereafter, it is helpful in analysing cerebral blood flow changes with comparison difference in rCBV between normal tissue and ischemic tissue, and that with DWI finding in infarcted patient.

The Reliability and Validity Test of psychosocial Well-being Index(PWI) / 간호학회지

The purpose of this study is to test the reliability and validity test of PWI to utility of PWI, this newly developed by Sejin Jang which measures stress. The subject were 186 workers in service area. Cronbach's alpha and Guttman split-half coefficient is used to test the reliability of PWI. Factor analysis and the correlation of the GHQ-60, GHQ-30, GHQ-28, GHQ-20, and GHQ-12 with the PWI is used to convergent validity and discriminant validity. The important results of this study are as follows : Cronbach's alpha coefficient of data was 0.894 and Guttman split-half coefficient was 0.7097. The PWI was classified as 13 principle component(eigenvalue>1.0). After exploring 4 factor structure according to previous study result, 4 factors was explained 40.5% out of the total variance. The factor 1 was explained 15.9% and then the rest three factor was 24.6%. Factor 2 and 4 showed good agreement but factor 1 and 3 did not. Depression-related items were classified two factors. Anxiety and depression-related items were loaded unifactor. It was not clear that the PWI was consist of 4 concepts(factors). The correlation of the GHQ-60, GHQ-30, GHQ-28, GHQ-20, and GHQ-12 with the PWI were 0.744~0.905. According to findings of this study, the PWI showed a high degree of validity and reliability. Thus it is recommended to use the PWI in general setting for screening for stress. In addition, it is necessary to clarify the concept of depression and anxiety. In the further study, it may be considered to the factor structure of PWI and studied to two or unidimensional factor structure.