ABSTRACT
Background: Although nadifloxacin has been shown to be effective in the treatment of skin & soft tissue infections (SSTI), there is a paucity of data comparing its efficacy and safety with other antibacterials, especially in Indian paediatric population. Therefore, objective of this study was to compare the safety and efficacy of nadifloxacin with mupirocin in children with SSTI.Methods: This was a single-centre, open label, randomized, parallel group, comparative study in 60 children of <12 years of age with SSTI. Test group (n=30) received nadifloxacin 1% ointment and reference group (n=30) received mupirocin 1% ointment, to be applied twice daily. Patients were followed up at day 4, 8 and 15. Efficacy of the study drugs was evaluated by clinical and bacteriological cure rate. Safety was assessed by reporting of adverse events.Results: Baseline characteristics of enrolled patients were comparable between treatment groups and all 60 patients completed the study. At Day 15, 100.0% cases among nadifloxacin group and 96.7% cases among mupirocin group achieved clinical cure (p=0.313). The most common bacteria found in culture were Gram positive cocci in both the groups (86.7% in nadifloxacin and 58.8% in mupirocin group). None of the cases in any of the groups showed bacteriological presence at day 15. No adverse event was reported in any of the treatment groups during the study duration.Conclusions: Nadifloxacin was found to be equally efficacious and safe to mupirocin in the treatment of SSTI in Indian pediatric population.
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@#BACKGROUND: Ultrasound has the fi rst line investigation role in the diagnosis of acute appendicitis in children. The purpose of this study was to perform a quality assessment review on the visualization rate of appendix on ultrasound in children in the community hospital setting. METHODS: A retrospective chart review of the abdominal ultrasound findings for the visualization of the appendix was performed on paediatric patients ranging from 5 to 18 years. Data were collected from the two community hospitals of Toronto by using hospital electronic medical record for the ultrasound fi ndings in patients presented with abdominal pain. RESULTS: Data from two community hospitals indicated visualization rate of the appendix as 11.0% and 23.2% for site 1 and site 2 respectively. In cases where the ultrasound was repeated the visualization rate remains the same. A two-proportion z-test was performed to find whether the visualization of appendix increases the likelihood of diagnosing appendicitis. The results revealed that the visualization of an appendix (P=0.52), signifi cantly improved the diagnosis of appendicitis (z=34, P<0.001). CONCLUSION: Visualization of an appendix on ultrasound increases the likelihood of correctly diagnosing appendicitis. In our study, we found low visualization rate of appendix on ultrasound that could be the result of many factors that contribute towards the low visualization rate of an appendix on ultrasound. Hence, the challenges in identifying appendix should be minimized to improve the visualization and diagnosis of appendicitis on ultrasound.
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Background: The need of securing the airway quickly in an easier and safer way, especially in paediatric patients still remains a major concern. Newer and safer alternates to endotracheal intubations are being introduced. LMA supreme is one of such advancement in the field of paediatric anaesthesiology. Easy and quick insertion without any introducer, gastric access and high seal pressure are few advantages claimed by LMA Supreme. Apart from a few studies; the safety and efficacy of its paediatric version is yet to be established in Indian paediatric population. Thus, we have conducted an observational study for evaluation of Supreme LMA in paediatric patients. Observational clinical study. Methods: After obtaining approval from institutional ethical committee and consent from patient’s attendants, 50 patients of ASA grade I and II, weighing 10-20 kg of either sex undergoing general anaesthesia were included. After induction of anaesthesia and muscle relaxation, the LMA Supreme size 2 was inserted. Number of insertion attempts, ease of insertion, time taken for insertion, hemodynamic responses, ease of NGT insertion and incidence of airway trauma were recorded. Results: In 90% of patients, LMA Supreme was inserted in first attempt. In 94% of cases, insertion was easy. Average time required to insert LMA Supreme was 11.66 ± 0.81 seconds. There were no significant hemodynamic changes noted. In 2 % of cases, airway trauma was observed. Conclusion: LMA supreme emerged as a good alternate airway device. It is quick and easy to insert with fast learning curve with least alteration of hemodynamic status in paediatric population.
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Intorduction:The present study was conducted in the departments of Anatomy, Radiology and Paediatrics at a General Public Charitable Hospital, Mumbai. Method: The study group consisted of 160 children of both sexes, who were referred to the Radiology department for ultrasonography. Out of these 160 chidren, 80 underwent sonography for abdominal and/or pelvic problems unrelated to the spleen and 80 children were suffering from medical disorders related to spleen i.e. 55 patients of thalassemia major, 13 patients of malaria, 9 patients of typhoid and 3 patients of portal hypertension. The splenic length was measured by using a commercially available real time ultrasound system with a TOSHIBA ECOCEE USG SYSTEM particularly by using the convex probe. Result: In the present study in abnormal spleen group, there is a strong correlation between weight and splenic size, and between age and splenic size, there is a partial correlation between height and the splenic size. In all the children with clinically obvious splenomegaly, the splenic length exceeded at least 2 cm than the normal splenic length at that particular age.Conclusion : This study shall stand as a good reference to Radiologists, Paediatricians, Haematologists and Physicians in an undiagnosed and complicated cases and will also helpful to determine the mode of treatment in thalassemia major with splenomegaly.
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Objetivo Evaluar las diferentes características diagnósticas de la función renal relativa (FRR) y de la función renal relativa normalizada por volumen renal relativo (FRRN), con el fin de analizar la posible mejora diagnóstica que implicaría su uso conjunto. Métodos Hemos estudiado con 99mTc-DMSA 952 unidades renales (riñones individuales), que pertenecían a 476 pacientes pediátricos (269 niñas) de edades comprendidas entre 0 y 11 años. De ellas, 355 unidades renales se consideraron patológicas a partir del análisis visual gammagráfico. Se determinaron los puntos de corte más apropiados para establecer los valores normales de las funciones FRR y FRRN, considerando como patrón de referencia al análisis visual gammagráfico. Se realizaron curvas ROC y se calculó el índice J de Youden y la exactitud para diferentes puntos de corte desde 42 por ciento hasta 50 por ciento, tanto para la FRR como para la FRRN. Se realizó también un análisis bayesiano (global y parcial clasificando las unidades renales por indicaciones clínicas) de la FRR y la FRRN. Resultados Para la FRR el mejor punto de corte fue 45 por ciento y para la FRRN fue 47 por ciento. El análisis bayesiano global mostró mejores resultados de los diferentes parámetros estadísticos para la FRRN. El análisis bayesiano parcial indicaba un importante incremento de la sensibilidad en pacientes con patología de dilatación de vía: de 10 por ciento (FRR) a 74.6 por ciento (FRRN); y con pielonefritis aguda: de 29.2 por ciento (FRR) a 66.2 por ciento (FRRN) mientras que en pacientes con nefropatías crónicas la sensibilidad fue similar (70.1 por ciento). Conclusión El cálculo de la FRRN (punto de corte 47 por ciento) proporciona información útil y complementaria a la FRR, ya que cuantifica la calidad relativa del riñón independientemente del volumen renal y refleja mejor los hallazgos gammagráficos.
Purpose To assess the different diagnostic features of relative renal function (RRF) and volume normalized relative renal function (NRRF) with the aim of analysing the possible diagnostic improvement that would imply their joint use. Methods We studied 952 kidneys with 99mTc-DMSA, belonging to 476 paediatric patients (269 girls) aged 0-11 years. 355 out of total were considered pathologic (visual analysis). The most appropriate cut-off points for establishing normality of RRF and NRRF were determined, considering as gold standard the visual scintigraphic analysis. R.O.C. curves were performed, J Youden index and accuracy were calculated for the different cut-off points from 42 percent to 50 percent for RRF and NRRF. A bayesian analysis (global and partial according to clinical indications) of RRF and NRRF was also performed. Results For RRF the better cut-off point was 45 percent and for NRRF 47 percent. The global bayesian analysis showed better values of the different statistical parameters for NRRF. Partial bayesian analysis indicated an important increment of sensitivity in patients with dilated pyelocalicial system: from 10 percent (RRF) to 74.6 percent (NRRF); and acute pyelonephritis: from 29.2 percent (RRF) to 66.2 percent (NRRF) while the sensitivity in patients with chronic nephropathy remained stable (70.1 percent). Conclusion NRRF calculation (cut-off 47 percent) provides useful and additional information to RRF, as it quantifies the relative quality of kidney tissue regardless of renal volume and better reflects better the scintigraphic findings.