ABSTRACT
Palisaded encapsulated neuroma (PEN) is a rare, benign, cutaneous nerve sheath tumor, which usually appears as a solitary asymptomatic skin-colored papule, which usually affects the face of middle-aged adults. Here, we report a case of PEN with unusual clinical features in a 23-year-old female, developed on the back, accompanied with pain sensation. Histopathologically, it appeared as a well-circumscribed, encapsulated round nodule, consisted of uniform, broad, and interlacing fascicles of the spindle cells in the dermis. On immunohistochemical staining, the tumor cells of nodule were positive for S-100 protein and neural filaments, while the capsule of the nodule was focally positive for the epithelial membrane antigen.
Subject(s)
Adult , Female , Humans , Young Adult , Dermis , Mucin-1 , Neuroma , S100 Proteins , SensationABSTRACT
Palisaded encapsulated neuroma (PEN) is a benign cutaneous neural tumor. It usually presents in adults as a solitary asymptomatic skin-colored papule that is almost always on the face. We report here on an uncommon case of plexiform PEN that developed on the penis of a 43-year-old man. It was 6 mm-sized skin colored papule. Histologically, there is an encapsulated nodule with a plexiform growth pattern in the dermis and a palisading arrangement of nuclei. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 and neurofilament.
Subject(s)
Adult , Humans , Male , Dermis , Neuroma , Penis , SkinABSTRACT
Palisaded encapsulated neuroma (PEN) is a clinically-distinctive, benign, cutaneous nerve sheath tumor. It usually occurs as a solitary, asymptomatic, skin-colored papule, and commonly affects the face of middle-aged adults. We report a case of PEN which developed on the lower lip of a 44-year-old Korean man. It was a 5mm-sized skin colored papule. Histopathologically, it consisted of uniform, broad, interlacing fascicles of spindle cells and was surrounded by a complete capsule in the dermis. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 protein and neural filaments, whil the capsule of the nodule was positive for epithelial antigen.
Subject(s)
Adult , Humans , Dermis , Lip , Neuroma , S100 Proteins , SkinABSTRACT
Palisaded encapsulated neuroma (PEN) is a rare intraneural neuroma. It usually occurs as a solitary asymptomatic skin-colored papule, and commonly affects the butterfly area of the face of middle-aged adults. We report a case of PEN which developed on the right upper eyelid of a 30-year-old man. It was a 3 mm-sized skin colored papule, and histologically, there was a well- defined encapsulated nodule in the dermis, composed of spindle cells with basophilic and plump nuclei in a palisading pattern. On immunohistochemical staining, the tumor cells of the nodule were positive for S-100 protein, while the capsule of the nodule was positive for epithelial membrane antigen.
Subject(s)
Adult , Humans , Basophils , Butterflies , Dermis , Eyelids , Mucin-1 , Neuroma , S100 Proteins , SkinABSTRACT
Palisaded encapsulated neuroma(PEN) is a rare intraneural neuroma. It usually occurs as a solitary, asymptomatic, skin-colored papule, and commonly affects the butterfly area of the face of middle-aged adults. However, it rarely involves oral mucosa including lip and should be differentiated from mucosal neuromas which generally occur as multiple small nodules of the lips and the anterior part of the tongue. We report a case of PEN occurring on the lower lip in a 33-year-old male. Histopathologically, it appeared as a well-circumscribed, encapsulated round nodule in the dermis. The nodule was composed of well-developed fascicles of wavy spindle cells separated by a loose matrix. Nuclear palisades were ill defined. On immunohistochemical staining, most tumor cells of the nodule were positive for S-100 protein and about 30% of tumor cells were positive for neural filament, but the capsule was negative for them. Epithelial membrane antigen was focally and discontinuously reactive on the capsule of the nodule.
Subject(s)
Adult , Humans , Male , Butterflies , Dermis , Lip , Mouth Mucosa , Mucin-1 , Neuroma , S100 Proteins , TongueABSTRACT
Palisaded encapsulated neuroma is a benign neural tumor located almost exclusively on the face of middle-aged adults. We report a case of palisaded encapsulated neuroma which developed on the upper lip of a 45-year-old man. Clinically, the lesion was asymptomatic, solitary, dome-shaped, pink papule. Histologically, there was a well-demarcated dermal nodule composed of fascicles of Schwann cells. On Bielschowsky staining, numerous axons were observed.
Subject(s)
Adult , Humans , Middle Aged , Axons , Lip , Neuroma , Schwann CellsABSTRACT
Palisaded encapsulated neuroma is a benign neural tumor located almost exclusively on the face of middle-aged adults. We report a case of palisaded encapsulated neuroma which developed on the upper lip of a 45-year-old man. Clinically, the lesion was asymptomatic, solitary, dome-shaped, pink papule. Histologically, there was a well-demarcated dermal nodule composed of fascicles of Schwann cells. On Bielschowsky staining, numerous axons were observed.
Subject(s)
Adult , Humans , Middle Aged , Axons , Lip , Neuroma , Schwann CellsABSTRACT
Palisaded encapsulated neuroma is a primary hyperplasia of Schwann cell and axon nerve fiber. It is characterized clinically by a solitary, slowly-growing and dome-shaped papule or nodule, and histopathologically by encapsulated nodule in the dermis and the palisading arrangement of nuclei. We report a case of palisaded encapsulated neuroma which had developed in the face of a 22-year-old female over the course of about 6months. Histopathological findings showed a well-demarcated intradermal nodule and its capsule. The nodule is composed of spindle cell with prominat basophilic nuclei and little cytoplasm in a palisading fashion. We report a case of palisaded encapsulated neuroma with a review of the literature.
Subject(s)
Female , Humans , Young Adult , Axons , Basophils , Cytoplasm , Dermis , Hyperplasia , Nerve Fibers , NeuromaABSTRACT
Palisaded encapsulated neuroma (PEN) is a distinctive benign cutaneous tumor that was first described by Reed et al. in 1972. We have recently experienced two cases of PEN. Clinically, these lesions were asymptomatic, flesh-colored or reddish brown papules or nodules. Light microscopy revealed several lobulated, partially encapsulated dermal tumors composed of interlacing Schwann cell fascicles. In some areas, palisading of nuclei was observed, but this was not characteristic. On Bodian staining, moderate to large numbers of tiny axons were observed. Electron microscopy demonstrated many myelinated axons incompletely invested by Schwan cell cytoplasm.