Research advances in functional regulation of islet α cells / 中华内分泌代谢杂志

Dysfuntion ofα cells plays a critical role in the pathogenesis of diabetes. Its own transcription factors, posttranscriptional modification, transporters related to secretion and paracrine signals fromβ and δ cells, inflammatory factors, and carbohydrates, lipids, amino acids, all influenceαcell function. We summaried the various factors involved in the regulation ofαcell function as well as recent related advances on their molecular mechanisms.