ABSTRACT
Objective To investigate the clinical characteristics of liver injury in patients with Non-biliariogenous acute pancreatitis complicated with metabolic syndrome (MS).Methods There were 63 patients complicated with MS (the MS group) and 145 patients without MS (the non-MS group) hospitalized in our hospital were evaluated.The general conditions,body mass index (BMI),C reactive protein (CRP),blood lipid (TG),blood glucose,alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBIL) and albumin (ALB) were compared between the two groups.Results BMI,CRP,blood lipid and blood sugar in MS group were significantly higher than those in non MS group (P＜0.05).LevelsofALT[(123.4±16.7)U/Lvs(63.8±8.5)U/L,P＜0.05],AST[(84.7±13.1) U/L vs (55.7 ±7.1)U/L,P＜0.05],TBIL [(32.3 ±12.9)U/L vs (21.7 ±10.4)μmol/L,P＜0.05] in the MS group were higher than that in the non-MS group (P ＜ 0.05).The abnormal liver function in MS group was mostly elevated by AST and TBIL,but only elevation of AST in MS group.Conclusions The incidence of liver injury in patients with non biliary acute pancreatitis combined with metabolic syndrome is high and much heavier.In the diagnosis and treatment of such patients,the changes of liver function should be closely monitored and the active treatment should be strengthened.
ABSTRACT
Objective To investigate the clinical features of patients with hypertriglyceridemia-induced acute pancreatitis (HTGP) and the influence of hypertriglyceridemia on severity or progress of acute pancreatitis.Methods By retrospective analysis,45 patients with HTGP and 184 patients with acute biliary pancreatitis (ABP) were studied.Age,gender,medical history,severity and complications were recorded and analyzed.Results Compared to ABP group,HTGP patients were significantly younger,more patients were observed in the diabetes,obesity and pregnancy.The hospitalization days in the HTGP group were much longer than that in the ABP group.The number of patients with severe acute pancreatitis (SAP) in the HTGP group were significantly higher than that in the ABP group (11/45 vs 20/184).The Ranson scores in the HTGP group were significantly higher than ABP group (2.58 ± 1.78 vs 1.98 ± 1.26).The number of HTGP patients with respiratory failure,renal failure,circulatory failure and systemic inflammatory response syndrome (SIRS) were higher than that in ABP patients.More HTGP patients had acute peripancreatic fluid collection (APFC),pancreatic pseudocysts and pancreatic necrosis than ABP patients.The mortality in IITGP group was higher than that in ABP group.Conclusions HTGP patients are younger,have more comorbidities and complications,with a trend towards more severe disease.To improve the prognosis are crucial in treatment of HTGP.