ABSTRACT
Sushruta Samhita is one of the foundational literature included in the Brihat traiye literatures of Ayurveda. Out of 37 different Ganas mentioned in Sutra Sthana of Sushruta Samhita, Dravya-sangrahaniya-adhyaya; Salsaradi-gana is one of them in which 23 medicinal plants have been described. Classically Salsaradi-gana is clinically indicated for Kushta (skin diseases), Prameha (diabetes mellitus), Pandu (anemia), and Kapha-medo-vishoshana (anti-hyperlipidaemic) disease. For this study, a review of the original commentary of Acharya Dalhana and Acharya haranchandra on Sushruta Samhita and the scientific research papers published on the medicinal plants listed in the Salsaradi-gana of Sushruta Samhita in indexed journals is done. Out of 23 medicinal plants mentioned 8 plants have controversial identification. The controversy in the identification of these medicinal plants is seen directly affecting the pharmacological action and clinical efficacy. Those 8 plants’ controversial identity is cleared with the establishment of a genuine plant for each of the plants through scientific and classical justification.
ABSTRACT
In the genesis of a disease, Nidan or Hetu (causative factors) play the most crucial role. When vitiated Doshas afflict Dhatus- this conglomeration leads to a state of Vikriti (disequilibrium) in our body which further leads to genesis of one or more disease. In respect of any disease, the role of Hetu can be divided in to three pathways- Dosha Prakopan (vitiation of Doshas by Hetu), Kha Vaigunya (impairment of channels by Hetu) and Dhatu Dusti (vitiation of Dhatus by Hetu). The role of any causative factor in relation with genesis of a particular disease can be viewed in respect with any of these three pathways. In this article, the authors have made an effort to explain the role of Hetu in light of above mentioned concept. To understand it better, we have taken an example of Pandu. Pandu is a disease which has been described with great importance in all major and minor texts of Ayurveda. It is caused by vitiation of Pitta Dosha, mainly Sadhak Pitta and affliction of mainly Rakta Dhatu. The role of each and every Hetu in genesis of Pandu has been explained through their role in Dosha Prakopana (vitiation of Pitta Dosha), Dhatu Dusti (Rakta Dusti) and Kha Vaigunya (impairment of channels).
ABSTRACT
Panduroga is a condition where in Pitta Pradhana Tridoshas affect the Dhathus causing deterioration of Varna and Bala, leading to Twak Vaivarnyatha or Pandutha. In present day medical science, symptoms of Pandu are alike to that of anaemia. Anemia is a condition presenting with a depletion of hemoglobin concentration below normal values, or Hematocrit or Red blood cells in the blood. On an average, about 30% or nearly one third of world’s population is claimed to be affected by anemia because of numerous causes. In India prevalence is extremely high compared to world prevalence, close to 51%. Nutritional macrocytic anemia (NMA) in prevailing population and in pregnancy, commonly seen in India, most likely represents combined deficiency of iron, folic acid and vitamin B12. A 45 years old female presented with complaints of Panduta (Pallor of skin), Daurbalya (weakness), Aruchi (loss of appetite), Padashopha (pedal oedema), Pindikodweshtana (leg cramps), Shrama Shwasa (exertional dyspnoea) and Hriddrava (palpitation) with haemoglobin concentration 3.7gm% visited OPD of SJIIM, GAMC, Bengaluru. Initially she was started with oral medications followed by admission to in-patient ward on the succeeding visit. The present case study is intended to understand the accuracy of multimodal Ayurvedic approach consisting of oral medications and Matra Basti with Dadimadya Ghrita, in the management of Panduroga and is found to be effective in overcoming Vataja Pandu
ABSTRACT
Nutritional anaemia is frequently observed in India. Prevalence of anaemia in Indian children is 59% (Hb<11gm/dl) but it’s higher among rural children. Iron deficiency is most common type nutritional deficiency anaemia in children. The nearest correlation of iron deficiency anemia (IDA) can be made with Pandu Roga in Ayurveda. The side effects of oral allopathic iron preparations are very common, therefore to get a better alternative, two Ayurvedic medicines, the Guda Haritaki and Punarnava Mandura, were subjected to a clinical trial among children suffering from IDA. Aim: Determine the role of Guda Haritaki and Punarnava Mandura in the management of Pandu roga w.s.r. to iron deficiency anaemia among children. Materials and Methods: The study was conducted on 35 children of IDA for a period of 6 weeks. Clinical features (Panduta, Daurbalya etc.) and hematological parameters (Hb gm %, sr. ferritin etc.) were documented before, during and after treatment. Statistical Analysis Used: Observations of the study were analyzed and findings were evaluated by using statistical methods Results: In the present study 58.82% improvement in Panduta was observed with Guda haritaki, 65% with Punarnava Mandura and 67 % when both drugs were given together. No adverse effect of the trial drug was observed during the study. Conclusions: The results suggest that Punarnava mandura along with Guda Haritaki is more effective in comparison to single use of either formulation in the management of IDA in children.
ABSTRACT
Background: The prevalence of anaemia in general and iron deficiency anaemia in particular is presently rising in the society. The primary objective of this study was to determine the prevalence of anaemia among school going children in rural and semi urban areas of Kangra district (Himachal Pradesh). Secondary objective was to identify the etiological and contributory factors in anaemia on the basis of Ayurvedic fundamentals. Methods: A population of 200 children studying in different schools of rural and semi urban areas of Kangra district Himachal Pradesh and IPD as well as OPD of department of Kaumarbhritya, R.G.G. P.G. Ayurvedic college and hospital Paprola were included in the survey. The data obtained from the survey was evaluated to assess the prevalence of anemia and its correlates. To fulfill the aims and objectives a specially prepared performa was designed and all details of the children were recorded in it. Results: The prevalence of anaemia was found to be 69% in school going children in rural areas of Kangra district, Himachal Pradesh. The major risk factors which were observed in present study were nutrition, socio-economic status, pica and dewormification. Conclusion: Anaemia is comparatively more common among children of semi urban and rural areas of Himachal Pradesh possible due to multiple factors like low socioeconomic status, menstruation and inadequate diet etc.
ABSTRACT
Ayapodi Elagam (A.E) was used in Siddha system of medicine for many years to treat Pandu (Anemia). This medicine contains Nellikai, Keezhanelli, Karisalai and Ayam. These herbs are helps to improve the blood to correct the anemia. This study was carried out to evaluate the acute and chronic toxic effect on Ayapodi Elagam and to determine the LD50. The toxicity study was done as per the guidelines of world health organization (WHO) guideline. As the herbs and Ayam were used for treating anemia by traditional practitioners for years together, the toxicity study was also proposed to study in both sexes. In acute study the animals were divided into two groups A.E was administered at 5000mg/kg orally and animals were observed for toxic sign at 0,5,1,4,24 hour and for 14 days. In chronic toxicity study A.E was administered at 450,900 and 1800 mg/kg body weight/day to 3 groups of animal, respectively. The distilled water was administered to control animals. The result showed that the acute toxicity study of A.E. at the dose level of 5000mg/kg does not produce any toxic sign and mortality among the experimental groups and the LD50 value of the drug was found to be more than 5000mg/kg bodyweight. The weight of rats, wellness parameters, mortality, hematological parameters, biochemical parameters and histological analysis of all vital organs were observed to know the chronic toxic effect of the drug. All the parameters of the study do not show the any significant chances between the control and experimental groups.
ABSTRACT
Pandu means pallor. In this disease there is predominance of paleness all over the body. due to its similarity it can be co-related with modern disease anaemia. Pandu Roga is explained by almost all of our Acharyas. This article is based on Nidanapanchaka of Pandu Roga from Ayurvedic texts as Charak samhita, Susruta samhita, Astanga hrudaya etc with all commentaries. Rasavaha and Raktavaha srotas are chiefly involved in pathogenesis of Pandu Roga. The changing lifestyle of human being by means of Ahara and Vihar plays a major role in manifestation of various diseases. Pandu Roga is also one of them. Our faulty dietary habits and lifestyle produces Ama which further causes Agnimandya and ultimately Amayukta Ahararasa produced. It hampers Rasa Dhatu utpatti and manifests Pandu Roga. Aggravated Pitta is responsible for the production of Posaka (nutrient portion) from the Rasadhatu as a result depletion of Rakta takes place. The detail knowledge of Nidanapanchaka and types of Pandu Roga will help in its diagnosis and management in this modern era also.
ABSTRACT
Context: Nutritional iron deficiency is the most common cause of anemia in India. The nearest correlation of iron deficiency anemia (IDA) can be made with Pandu Roga in Ayurveda. As the IDA is a very common prevalent disease in the society and the side effects of oral allopathic iron preparations are very common, therefore to get a better alternative, an Ayurvedic herbomineral medicine, the Trikatrayadi Lauha, was subjected to a clinical trial in children suffering from IDA. Aim: Evaluation of safety and efficacy of the compound Trikatrayadi Lauha suspension in children with IDA. Settings and Design: Randomized, double-blind placebo-controlled clinical study. Materials and Methods: The study was conducted on 123 children of IDA for a period of 10 weeks. Clinical features and hematological parameters were documented before, during and after treatment. Statistical Analysis Used: Observations of the study were analyzed and findings were evaluated by using statistical methods (Student's t test) Results: The present study shows that the trial drug Trikatrayadi Lauha suspension is effective to improve clinical features and hematological parameters significantly. The medicine is effective to increase the hemoglobin level 1.94 g/dL (8.52 -10.46 g/dL, P < 0.001) in 5 weeks and 3.33g/dL (8.52 -11.85g/dL, P < 0.001) in 10 weeks. No adverse effect of the trial drug was observed during the study. Conclusions: The results suggest that Trikatrayadi Lauha is significantly effective in the management of IDA in children.