ABSTRACT
El cáncer de mama triple negativo es un tumor agresivo que, muy pocas veces en la clínica, se presenta con un síndrome neurológico paraneoplásico asociado a un carcinoma metastásico de origen desconocido. Este artículo reporta una paciente con tal asociación y que su caso fue discutida en Clínica Patológica Institucional(AU)
Triple negative breast cancer is an aggressive tumor that, in the clinic, rarely presents with a paraneoplastic neurological syndrome associated with a metastatic carcinoma of unknown origin. This article reports a patient with such an association and that was discussed in Institutional Pathological Clinic(AU)
Subject(s)
Humans , Female , Middle Aged , Triple Negative Breast Neoplasms/complications , Triple Negative Breast Neoplasms/diagnosis , Case Reports , Paraneoplastic Syndromes, Nervous System/complicationsABSTRACT
Autoimmune encephalitis is a recently defined heterogeneous group of disorders probably resulting from an immune reaction against neuronal antigens.The characteristic clinical features include cognitive decline,seizures and behavioral disturbances.Autoimmune encephalitis,often improved with immune-modulatory therapies,is an important cause of rapidly progressive cognitive decline and behavioral problems.The recent knowledge about the syndromes was reviewed,and the clinical manifestations,diagnosis and treatment strategy were focused.
ABSTRACT
Objective To investigate the proliferative response of peripheral blood mononuclear cells(PBMC) and its depressant effect on small cell lung cancer(SCLC)cells(H446) in patients with paraneoplastic neurological syndrome(PNS).Methods PBMC of 7 patients with PNS and 6 patients with SCLC were cultured with interleukin(IL)-2 in vitro,then cultured separately or mixed with H446 respectively.The proliferation index(PI,the ratio of cellular score which had proliferated and that had not proliferated) of H446,PBMC,CD4+,CD8+ T cell and the ratio of CD4+,CD8+,CD4+/CD8+ were analyzed with flow cytometry and compared with normal control group.Results Compared with cultured separately,the PI of H446,PBMC,CD4+,CD8+T cell in PBMC of PNS and SCLC groups cultured with H446 were not significantly different.Stimulated by IL-2,the ratio of CD4+ T cell in PNS patients [(76.54 ? 3.96)%]was higher than that in normal control group[(51.75 ? 17.3)%](P