ABSTRACT
Paraquat(Gramoxone) is the most commonly used herbicide in Korea. But serious paraquat poisoning in human beings has occurred following ingestion or exposure to the skin. Exposure to paraquat through the skin has resulted in local irritation or inflammation of varyiig degree, sometimes severe. We report three cases of primary irritant dermatitis due to paraquat. Two patients developed generalized vesicobullae and necrotirulcer in the scrotum, respectively. The other patient developed painful whitish patch and erosion in ttie tongue after accidental exposure.
Subject(s)
Humans , Dermatitis, Irritant , Eating , Inflammation , Korea , Paraquat , Poisoning , Scrotum , Skin , TongueABSTRACT
A 62-year-old farmer was admitted to our department because of second degree chemical burns of both buttocks ten days following accidental contact with Gramoxone, a weed killer. He was treated with oral antibiotics and cold compresses and discharged after the burned area were reepithelialized. Laboratory findings were within normal limits for three weeks. Although lung fibrosis, hepatic and renal failure can be caused by repeated absorption of paraquat (Gramoxone) through injuried skin, systemic absorption through normal skin has not been reported. During the four month follow up period there were no systemic problems nor recurrence of skin lesions. We report herein a case of chemical burns induced by Gramoxone, which is probably an occupational dermatosis of farmers handling weed killers.
Subject(s)
Humans , Middle Aged , Absorption , Anti-Bacterial Agents , Burns , Burns, Chemical , Buttocks , Fibrosis , Follow-Up Studies , Lung , Paraquat , Recurrence , Renal Insufficiency , Skin , Skin DiseasesABSTRACT
São apresentados dois casos de pacientes com lesões viscerais do fígado e rins consequentes ao manuseio inadequado de um agrotóxico, o dicloreto de paraquat 1,1'-dimetil-4,4'-dipiridilio dicloreto (Gramoxone) e chamam a atenção para um tipo especial de hepatite tóxica; descrevem o tipo de lesão hepática Q sua topografia intralobular, assim como lesões graves nos túbulos renais, com formação de sais de cálcio. São feitas considerações sobre as vias de absorção do tóxico e das áreas de predileção de atuação dentro do lóbulo hepático, assim como sobre o diagnóstico diferencial com outros tipos de hepatite tóxica (AU).