ABSTRACT
Background: Hypertension (HTN) is one of the most common and a high-risk factor for cardiovascular disease. Aims and Objectives: This study aims to identify students who are at risk of developing HTN with positive parental history of HTN and to compare the effects of isotonic exercise on cardiovascular parameters among the students with and without positive history of parental HTN. Materials and Methods: A total of 50 students participated in the study out of which 21 students had positive history of parental HTN with at least one parent having history of HTN and 29 students had negative history of parental HTN. Baseline pulse rate (PR), systolic blood pressure (SBP), and diastolic blood pressure (DBP) of the participants were recorded. Then, all the participants performed Harvard step test for 3 min. The SBP, DBP, and PR were measured immediately after stopping the exercise and after 3 min and after 5 min of stopping the exercise. Data were statistically analyzed using unpaired t-test and ANOVA. P < 0.05 was considered statistically significant. Results: PR recorded after 3 min of stopping of exercise was significantly higher in the participants with positive parental history of HTN than the other group. SBP recorded immediately and after 3 min and after 5 min of stopping exercise was significantly higher in the participants with a positive history of parental HTN as compared to the other group. However, no statistically significant difference was observed in DBP between the two groups. Conclusion: Students with positive parental history may have relatively higher risk of developing HTN in future as an exaggerated blood pressure response to exercise was observed in them in this study.
ABSTRACT
Objective To explore the influence of parental history of allergy on the cytokine level of umbilical cord blood of neonates.Methods A prospective study was conducted which selected the pregnant women attending Yiwu maternal and child healthcare hospital from July to December in 2012 as objects.The umbilical cord blood sample were collected to detect the level of IgE,eosinophile granulocyte,eotaxin,IL -9,IL -6,IL -4,IL -5,IFN -γand IL -10. Results A total of 136 subjects were recruited and divided into three groups according to the status of parental allergy histories.There was no significant difference in social and demographic characteristics among the three groups (P>0.05). Three groups have significantly different median concentration of IL-13 (1.82pg/mL vs.3.24pg/mL vs.6.12pg/mL), eotaxin (29.33pg/mL vs.50.71pg/mL vs.60.15pg/mL),IL-9 (43.75pg/mL vs.111.17pg/mL vs.183.19pg/mL), IL-6 (11.49pg/mL vs.19.35pg/mL vs.26.09pg/mL),IL-4 (3.67pg/mL vs.21.27pg/mL vs.49.51pg/mL),IL-5 (4.26pg/mL vs.7.69pg/mL vs.10.66pg/mL),IFN-γ(338.65pg/mL vs.649.17pg/mL vs.834.14pg/mL),IL-10 (7.13pg/mL vs.10.56pg/mL vs.14.64pg/mL),P <0.05.Conclusion Parental history of allergy could have influence on cytokine level of umbilical cord blood.Early screening and surveillance in neonates whose parents have history of allergy should be taken to guide early interventions.
ABSTRACT
Objective To explore the association between histories of hypertension in parents and level of blood pressure in their children so as to provide strategy for early intervention. Methods 19 088 children aged 6-17 years were selected in Beijing with stratified random cluster sampling method,and data on influencing factors including parental history of hypertension and other related environmental factors were collected.Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were examined.SPSS 13.0 was used for data analyses.Results The average prevalence of high blood pressure in children and adolescents was 9.13%based on the blood pressure criteria Beijing Children and Adolescents Metabolic Syndrome (BCAMS) set in 2004.Familial aggregation of hypertension in children and adolescents was observed (P＜0.001).There were positive associations between the numbers of parents with history of hypertension and both SBP and DBP of their offspring.Partial regression coefficients appeared to be 0.980 (95%CI:0.524-1.437) and 0.832 (95%CI:0.463-1.201) respectively,after controlling for con founding variables including gender,age,residential regions,body mass index (BMI),pubertal development,histories of smoking and drinking alcohol,fat intakes,physical exercises,parents' education level etc.Results from multiple factor logistic regression analysis showed that when compared with children whose parents did not have hypertension,the odds ratios of children having high blood pressure with only paternal history,only maternal history or with both parental histories were 1.688 (1.385-2.059),1.559 (1.164-2.087) and 1.273 (0.673-2.406),respectively,after adjustment for confounding factors.Conclusion Parental history of hypertension seemed to be an important independent risk factor for high blood pressure to their offspring.Heredity factors should be emphasized in the development of prevention and intervention on hypertension in children and adolescents.