1.
Journal of Medical Postgraduates
;
(12): 337-341, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-486124
ABSTRACT
Ketamine, a nons-elective N -methyl-D-aspartate (NMDA ) receptor antagonist , is widely used as a general anesthetic in clinical practice. Recent studies have shown that ketamine can produce rapid , effective, and long-lasting antidepressant effects , and the strength of synaptic plasticity induced by inhibitory interneurons , excitatory transmitters , AMPA receptors , and postsynaptic signal pathways may be involved in this procedure .The antidepressant effects of ketamine and the underlying mechanisms are concisely intro -duced in this paper .