Evaluation of the effects of passion fruit peel flour (Passiflora edulis fo. flavicarpa) on metabolic changes in HIV patients with lipodystrophy syndrome secondary to antiretroviral therapy

ABSTRACT This study evaluated the effects of using passion fruit peel flour together with diet therapy and counseling in 36 patients with HIV lipodystrophy who were in an ambulatory clinic in a university hospital. The patients were divided into two groups. One received 30 g of passion fruit peel flour daily for 90 days and diet therapy counseling. The other group received only diet therapy counseling. The metabolic changes were analyzed before and after the intervention, with a significance level predetermined at p ≤ 0.05. The use of passion fruit peel flour was effective in reducing total cholesterol and triacylglycerides after 30 days. The concentrations of LDL-C decreased, while HDL-C increased in the blood of lipodystrophy patients after 90 days passion fruit peel flour treatment. No significant differences in food consumption were seen between groups. The use of 30 g of passion fruit peel flour for 90 days together with diet therapy counseling was effective in improving plasma concentrations of total cholesterol, LDL-C, HDL-C and triacylglycerides.

Efeito do consumo da aveia e farinha da casca de maracujá sobre a glicemia e lipemia em um grupo de voluntários / Effect of consumption of oats and passion fruit peel flour on glycemia and lipemia in a gr oup of volunteers

The purpose of this article is to assess the effects ofconsuming (rolled) oat flakes and passion fruit peelflour on glycemia and lipemia in a group of volunteersof sedentary habits. A clinical study was conductedin 2010 with 28 people in the city of Viçosa (MinasGerais, Brazil), whose age ranged from 30 to 60 years.The subjects were divided randomly into two groupsof 14. Group 1 ate 30g of oat flakes and group 2, 30gof passion fruit peel flour, every day for 60 days. Todetermine the biochemical effects, blood samples werecollected at three times: the first at time zero (t0), thesecond after 30 days (t30) and the third after 60 days(t60). In group 1 (treated with oats), it was observedthat HDL levels increased, while the serum glucoseconcentration decreased significantly; however, thevariables body weight, total cholesterol and LDLdid not change statistically. In group 2 (treatedpassion fruit peel flour) the serum glucose and totalcholesterol concentration decreased significantly;however, the variables body weight, HDL and LDLdid not change statistically. The products used inthis study were effective in reducing serum glucoselevels and there was also an improvement in the lipidprofile.

O objetivo do presente artigo foi analisar os efeitos do consumo da aveia em flocos e da farinha da casca de maracujá sobre a glicemia e a lipemia em um grupo de voluntários, com hábitos sedentários. Foi realizado um estudo clínico com 28 pessoas na cidade de Viçosa, MG, no ano de 2010, com idade variando entre 30 a 60 anos, onde essas foram divididas de forma aleatória em dois grupos de 14 pessoas. O grupo 1 recebeu 30 g de aveia em flocos enquanto o grupo 2, 30 g de farinha da casca de maracujá, durante 60 dias. Para verificação dos resultados bioquímicos, foram realizadas três coletas de sangue: a primeira, no início do estudo (tempo zero), a segunda, após 30 (t30) dias; e a terceira, após 60 dias (t60). Com o uso da aveia em flocos, observou-se que a concentração de HDL aumentou e a concentração sérica de glicose diminuiu significativamente, porém as variáveis peso, colesterol total e LDL não diferiram estatisticamente. Com a ingestão da farinha da casca do maracujá, houve diminuição significativa das concentrações de glicose e de colesterol total, contudo, as variáveis peso, HDL e LDL não diferiram estatisticamente. Os produtos utilizados foram eficazes na redução da concentração sérica de glicose e houve também melhora no perfil lipídico.