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Objective@#To analyze the composition of prostatic calculus in patients with BPH and explore its pathogenic factors and histopathological characteristics.@*METHODS@#Strictly following the inclusion and exclusion criteria, we included in this retrospective study 580 cases of bipolar transurethral plasma kinetic prostatectomy (TUPKP) performed in our hospital from May 2015 to May 2019, analyzed the histopathological and calculus-composition features of the patients with BPH complicated by prostatic calculi (the BPH+PC group) and the histopathological data of those with BPH only (the BPH group). We compared the related factors between the two groups of patients and performed uni- and multivariate logistic regression analyses of the data on those in the BPH+PC group.@*RESULTS@#The incidence rate of chronic inflammation was significantly higher in the BPH+PC than in the BPH group (83.1% vs 61.1%, P 0.05). Logistic regression analyses showed that prostatic calculus was significantly correlated with chronic inflammation of the prostate, the patient's age and IPSS (P 0.05).@*CONCLUSIONS@#Prostatic calculus has a high incidence in BPH patients and varies widely in composition, chiefly consisting of calcium oxalate and carbonate apatite. The major factors contributing to prostatic calculi include chronic inflammation of the prostate (primarily the severe type), age and BPH. Prostate calculi may aggravate lower urinary tract symptoms, especially urinary storage symptoms, in patients with BPH, but not significantly affect the PSA level.？.
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Humans , Calculi , Prostatic Hyperplasia , Retrospective StudiesABSTRACT
Introduction: Maternal death (MD) is defined as deathof a woman occurring while pregnant or within 42 days oftermination of pregnancy irrespective of the duration or itsmanagement. Accidental or incidental causes are not included.Maternal mortality rate (MMR) of the region indicates thequality of maternal health care, availability of health carefacilities and overall socio-economical status of the populationin general. It is essential to know the exact cause responsiblefor maternal death which is possible by detailed autopsy andcareful pathological study under expert guidance.Material and Methods: Autopsy study was performed in100 consecutive cases of maternal deaths, over a period of22 months. Detailed gross and microscopic examination ofthe visceral organs that included uterus, placenta was carriedout in all cases of maternal deaths. Analysis of pathologicalfindings was done in the light of available clinical data.Results: Out of the 100 cases of maternal deaths 87%belonged to age group of 21 to 30 years. There were 52%deaths in antenatal period. Direct causes were responsible formaternal deaths in 52% cases, indirect causes in 43% casesand in 5% cases the causes were coincidental.Conclusion: Direct causes of MD were more frequent thanindirect causes in the present study. Haemorrhage beingthe most common direct cause of MD. Lesser accessibilityto health care facilities at peripheral health centres for theprospective mothers is highlighted by the present study.
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BACKGROUND:Oral cavity and oropharyngeal malignancies are a heterogeneous group of cancers arising from different parts of the oral cavity and oropharynx, with different predisposing factors, prevalence, and treatment outcomes. It is the sixth most common cancer reported globally. In India it accounts for majority of cancer mortality and morbidity, posing a significant challenge to health care providers by both preventive and diagnostic means. AIM:To evaluate the clinico-epidemiological profile of oral cavity and oropharyngeal malignancies and to study the histopathological type and differentiation of oral cavity and oropharyngeal malignancies. MATERALS AND METHODS: This study was conducted in department of Otorhinolaryngology,Government Medical College,Thrissur, for a period of one year from January 2016 to January2017. It was a cross sectional study. 100 patients with complaints of growth in oral cavity and oropharynx were selected using convenient sampling technique. Detailed history is recorded in a proforma, regarding age, sex, presenting complaints, habits of chewing tobacco, habit of smoking and consumption of alcohol. Thorough examination of oral cavity and oropharynx is performed, and site and morphology of growth is noted.Biopsy is taken from the growth and specimen sent for histopathological examination. Histopathological diagnosis regarding type and differentiation is made. RESULTS:100 patients with complaints of growth in the oral cavity and oropharynx were studied. Majority of patients were males [75%]. Maximum number of cases presented between 50 and 59 years of age (mean age: 60.85 years). Majority of patients were daily wage workers doing manuallabour[47%].73% of patients were smokers,52% were consumers of smokeless tobacco, while 73% were alcoholics.Oral lesion was the most common symptom in our study.Tongue was the commonest site [34%]followed by buccal mucosa [18%]. Squamous cell carcinoma was the commonest histological variety[96%]. Majority of the tumours were welldifferentiated.CONCLUSION: Malignancy of oral cavity and oropharynx is predominantly a disease ofmales and affects older age group.Manuallabourersand people with poor socio-economic background are more vulnerable to oral and oropharyngealmalignancies. Tobacco and alcohol consumption are important etiological factors for oral and oropharyngealmalignancies.Anterior part of oral cavity is commonly affected, and patients usually presents with oral lesion.Well differentiated squamous cell carcinoma is the commonest histologicalvariety.
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Background: The intradural extramedullary tumours of the spine are one of the commonest tumours of the spine. Early diagnosis and surgical removal helps in best outcome. The objective of the study was to analyze the clinical presentation, imageology, resectability, to know the incidence of different types of tumours in intradural extramedullary compartment and to study the surgical outcome. Methods: This was a prospective study of 32 cases of intradural extramedullary tumours. The clinical presentation, imageology, resectability, histopathology, surgical outcome were studied. The patients were investigated with plain spinal radiography and MRI. All cases were treated surgically by posterior or posterolateral approaches. Outcome and complications were evaluated. They were followed up regularly and the results were analyzed. Ambulatory status was classified on admission by using Nurick-grading scheme. Results: The incidence of intradural extramedullary spinal tumours was 57.14%. Most of the tumours presented in the third decade (37.5%). Mean age of Presentation for meningioma was 36 years and for nerve sheath tumours was 39.5 years. The nerve sheath tumours contributed 35% followed by meningioma 28%. Nerve sheath tumours were found to be most commonly located in thoracic region (56%). Total excision of tumour was achieved in 87.7% cases. Conclusions: Nerve Sheath tumours and Meningiomas were the most common in intradural extramedullary spinal lesions and complete excision was possible in almost all cases. Prognosis was usually good, in spite of poor neurological status at the time of presentation.
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Dry eye is one of the common chronic disease of ocular surface characterized by the stability of tear film decrease and ocular surface lesion .The change of tear film and the inflammatory reaction which based on immune and the neural regulation abnormality are the important factors in the occurrence , development of dry eye .Alterations in gene structure has become a new research direction , also computer image processing techniques and detection tech-niques of molecular biology gradually have been applying in research and diagnosis of dry eye .
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Objetivo. Evaluar la correlación entre la estadificación preoperatoria de los carcinomas de células renales usando tomografía computada y los resultados anatomopatológicos de la pieza operatoria. Materiales y Métodos. Se llevó a cabo un estudio retrospectivo entre los años 2005 y 2011, tomando un total de 40 pacientes con diagnóstico presuntivo de carcinoma de células renales (CCR) del Servicio de Urología, que habían sido sometidos a nefrectomía total o parcial. Se compararon diferentes parámetros del estudio imagenológico (tomografía computada) y anatomopatológico de cada paciente y se evaluó qué reciprocidad existía entre la estadificación pre y posoperatoria según el TNM. Resultados. Los datos obtenidos mediante el estudio anatomopatológico de la pieza operatoria mostraron 28 lesiones limitadas al riñón (estadios T1 y T2), 3 lesiones con extensión perirrenal y a la vena renal (estadio T3a), 7 lesiones con compromiso de la vena cava (estadio T3b) y 2 lesiones con extensión más allá de la fascia de Gerota (estadio T4). Se encontró una fuerza de concordancia casi perfecta entre la estadificación tomográfica y anatomopatológica (kappa = 0,87) con respecto al criterio T del TNM. Sólo 2 T1b (por estudio anatomopatológico) fueron sobrediagnosticados como T2 (según tomografía computada) y 2 T3b (según estudio anatomopatológico) se subdiagnosticaron como T3a (según tomografía computada). Conclusión. La tomografía computada proporciona una buena delimitación y caracterización del carcinoma de células renales. El nivel de concordancia con el patrón de referencia más fiable (anatomía patológica) resultó casi perfecto (k = 0,87) para la estadificación del estadio T.
Objective. To evaluate the correlation between the preoperative staging of renal cell carcinoma by computed tomography (CT) and histopathologic results of the surgical specimen. Materials and Methods. A retrospective study has been carried out in a total of 40 patients from our urology department with suspected diagnosis of renal cell carcinoma (RCC) who had undergone total or partial nephrectomy between 2005 and 2011. We compared different parameters of imaging (CT) and pathological studies of each patient and assessed the reciprocal relationship between pre-and postoperative staging according to TNM. Results. Data obtained by pathological examination of the resected specimen showed 28 lesions limited to the kidney (stages T1 and T2), 3 lesions with perirenal extension and renal vein (stage T3a), 7 lesions with involvement of the vena cava (stage T3b) and 2 lesions with extension beyond Gerota's fascia (stage T4). We found an almost perfect strength of agreement between tomographic and pathologic staging (kappa = 0.87), with respect to T of the TNM criteria. Only two T1b (by pathological study) were overdiagnosed as T2 (by computed tomography) and two T3b (by pathological study) were underdiagnosed as T3a (by CT). Conclusion. Computed tomography provides a good delineation and characterization of renal cell carcinoma. The level of agreement with the most reliable reference standard (pathological study) was almost perfect (k = 0.87) for the staging of T stage.
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Background : Granuloma annulare (GA), a common dermatological condition of unknown etiology, affecting all ages. Involvement of the palms appears rare, posing a diagnostic challenge. This study was conducted to document various clinical and histopathological features of GA on the palms. Aims: To study clinical and histopathological variations in granuloma annulare on palms. Methods : A total 7 patients from our outpatient department with lesions of GA, exclusively on the palms, were studied over a period of 6 months from March 2011 to August 2011. Total of 8 biopsies were studied. In each patient, diagnosis was made on clinico-pathological correlation. Various clinical and histopathological features were analyzed. Results: An average age of onset was 47 years, male: female ratio was 1.33: 1, and average disease duration was 9 months. Pain was the most common symptom. Clinically, the most common presentation was pseudovesicles. Histologically, both classic palisading and interstitial pattern were seen. Perineural granulomas, perieccrine granulomas, elastophagocytosis were seen additionally. In 5 out of 7 patients, diagnosis was missed clinically. Conclusion: GA on palms poses a diagnostic challenge due to variable presentations. Histopathology is of vital importance for correct diagnosis and treatment. GA should be considered in differential diagnosis of papular lesions on palms.
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Objective To evaluate the effects of preoperative regional artery chemotherapy (PRACT) on gastric carcinoma. Methods Celiac arteriography was performed by transfemoral artery catheter according to Seldinger's method and superselective catheterization proceeded to the supplying artery of focus of lesion. Antineoplastic agents of Fluorodeoxyuridine (FUDR)(0.8 g/m 2), epirubicin(40 mg/m 2), oxaliplatin(80 mg/m 2) were infused into regional artery by a single administration. The specimens from 14 cases of gastric carcinoma(GC) who received PRACT were separated into pre operation group and post operation group. Both microscopic study to observe the necrosis of cancer cell and TUNEL(TdT mediated dUTP nick end labeling) method to detect the state of apoptosis were performed respectively in the two groups. Correlation of apoptosis index (AI) between the two groups, as well as correlation between the situation of necrotic tumor cell and the blood vessel, was analyzed. Results The severity of the necrosis of tumor cell was significantly higher in the PRACT group than that in the untreated group ( P
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Immunohistochemical study of gliomas was maed using the indirect Avidin-Biotin Complex(ABC) method in order to investigate the presence and patterns of distribution of GFAP, neurofilament, and S-100 protein in 37 cases of human gliomas. Generally, two immunostaining patterns were observed; perikaryal and diffuse fibrillary background staining. All of the glial tumor cases were stained positively for GFAP except for the 3 oligodendrogliomas. The S-100 protein was sensitive for all the glial tumors and for neurofilament, in about half of the cases. These observations support previous reports that GFAP is specific for astrocytes, and that S-100 protein is sensitive, but not specific for glial tumors. Furthermore, our data suggest that immunostaining patterns of G.M. is different from that of astrocytoma grad II and III.