ABSTRACT
OBJECTIVE: To compare the efficacy, compliance, safety and economics of standard triple therapy and 10-day sequential therapy consisting of rabeprazole, clarithromycin, amoxicillin and tinidazole for Helicobacter pylori eradication. METHODS: A total of 90 pepticulcer patients who were Helicobacter pylori positive proved by C-urea breath test (C-UBT) were randomly divided into two groups. Forty-five patients received rabeprazole-based 10-day sequential therapy and the other forty-five patients received rabe-prazole-based 7-day standard triple therapy. C-UBT was carried out 4weeks after a course of treatment to evaluate the eradication of Helicobacter pylori. The two regimens were evaluated by cost-effectiveness analysis. RESULTS: Eighty-five patients completed the study. The Helicobacter pylori eradication rates by intention-to-treat (ITT) analysis and by per-protocol (PP) analysis in 10-day sequential therapy group were higher than those in 7-day standard triple therapy group (ITT: 91.1% vs. 73.3%, P<0.05; PP: 95.3% vs. 78.6%, P<0.05). The incidences of adverse reactions (PP: 14.0% vs. 11.9%, P<0.05) were similar in the two groups. The cost-effectiveness analysis showed that the C/E value of the 10-day sequential therapy were lower. CONCLUSION: Rabeprazole-based 10-day sequential therapy is more effective for eradication of Helicobacter pylori.
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0.05).The total treatment costs were(1084.43?247.38)yuan for the treatment group and(1211.23?275.95)yuan for the controlled group,which had significant difference(P0.05).The total costs were(1270.45?218.12)yuan for the treatment group and(1407.51?51.01)yuan for the controlled group(P
ABSTRACT
Based on the TCM theory of " Unity of Spirit and Body" and emotional changes causing diseases, rat models were made by bindking and wator -immersion methods to produce stress ulceration.' Counter -proved by treating such rats with compound - herbal recipe for regulating Qi descending adverse flowing and dissipating lumps, the Xinshen No. 1., it was proved that the nature of the functional disturbance in the models was the micro - circulatory disturbance of heural - hormonal system. Hence, the remedy yields therapeutic action spirit (emotional and psychic factors )and the body.