ABSTRACT
Objective To investigate the treatment effectsand safety of ifosfamide,nedaplatin with pharmorubicin in relapsed ovarian carcinoma.Methods Sixteen relapsed ovarian carcinoma patients received nedaplatin 150mg in 0.9% sodium chloride 500ml dl,intravenously;pharmorubicin 40mg in 5% glucose 50 ml d1-2,intravenously;and ffosfamide 2.0g in 0.9% sodium chloride 500ml d1-5,intravenously.And the treatment effects and side effects were investigated.Results Of the sixteen patients,one had a complete response,six had a partial response,seven had stable disease,and two had progressive disease.The overall response rate was 43.75%(7/16).The major side effects were bone marrow suppression and gastrointestinal reaction.Conclusion Combination of ffosfamide,nedaplatin and pharmorubicin were very effective in relapsed ovarian carcinoma and the side effects were tolerable.Therefore the regimen is worth promoting in the clinical application.
ABSTRACT
Purpose;To observe curative effect and side reaction ,histopathology change of dose - dense combinated pharmorubicin with paclitaxel in advanced breast cancer treatment. Methods ;38 patients with advanced breast cancer diagnosed by pathology, which had e-valuation index, pharmorubicin 50mg/m2 ,d1 , intravenous injection,paclitaxel 175mg/m2,d2,intravenous injection,every 2 weeks as 1 course of treatment,after accepted 2 - 4 course of treatment,all patients were evaluated. Results: All patients were followed up,clinical complete remission( CR) 10. 5% , clinical partial remission 71. 1% , total effective rate 81. 6% . effective rate in patents of initial treatment was much higher than that in patients of retreatmen; effective rate in patents of III stage also was much higher than that in patients of IV stage; low leucocyte and Neutropenia appeared III ,IV side reaction,occupying respectively 63.2% and 71. 1% ;7.9% patients febricity owing to low leucocyte were cured by G - CSF and antibiotics,all patients successfully accomplish chemotherapy. Other side reaction,for instance thrombocytopenia.anaemia,nausea and vomiting etc,mostly displayed I , II toxic reaction,but they can be tolerated. After chemotherapy,cancer cells degeneration . cellular necrosis . retrogression and interstitial fibrosis .inflammatory cell infiltration are obviously changed. Conclusion: dose -dense chemotherapy combinated pharmorubicin with paclitaxel in advanced breast cancer treatment, remission rate was much higher and remission rate can be tolerated.