Progress of relationship between phosphatase of regeneration liver-3 and tumors / 肿瘤研究与临床

Phosphatase of regenerating liver-3 (PRL-3) is a kind of non-transmembrane protein-tyrosine phosphatase, characterized by its promotion of cell proliferation, migration and invasion. It is highly expressed in many tumors and has a close correlation with tumorigenesis, metastasis and prognosis. With the further research in recently years, more and more studies have suggested that PRL-3 has a wide applicative prospect in clinic, serving as a important clinical biological marker to predict tumor metastasis and prognosis. This paper will review the structure of PRL-3, mechanism and relationship between PRL-3 and tumors.