ABSTRACT
Objective:To observe the effectiveness and security of piperacillin sodium/sulbactam sodium in the treatment of bacte-rial infections and perform the pharmacoeconomics evaluation. Methods: Totally 126 patients with hand trauma bacterial infections were divided into the control group and the treatment group. The control group was given piperacillin sodium/tazobactam sodium 2. 5g, ivd, bid, while the treatment group was treated with piperacillin sodium/sulbactam sodium 1. 25g, ivd, bid. After 14-day treatment, the clinical therapeutic effect and adverse reactions of the two groups were observed, and the cost-minimization analysis was carried out. Results:The effective rate of the treatment group was 93. 65%while that of the control group was 92. 06%(P>0. 05). The bac-terial clearance rate of the treatment group was 96. 83%while that of the control group was 95. 24% (P>0. 05). The incidence of ad-verse reactions of the treatment group was 4. 76% (3/63) while that of the control group was 9. 52%(P>0. 05). The cost-effective-ness of piperacillin/sulbactam was significantly lower than that of the control group (P<0. 05). Conclusion: The effectiveness and safety of the two groups show no obvious differences in the treatment of hand trauma bacterial infections, and both have good antibacte-rial effect with low incidence of adverse reactions. For the better economic benefits, piperacillin /sulbactam is worthy of promoted ap-plication.
ABSTRACT
Objective To offer reference to reasonable clinical use of piperacillin sodium sodium-tazobactam sodium .Methods We reviewed pharmacokinetic/pharmacodynamic studies , clinical trails and implementation of piperacillin sodium-tazobactam sodi-um alternative dosing regimen in recent .Results The alternative dosing regimens , prolonged and continuous infusion , could maximise the likelihood of achieving desirable pharmacodynamic targets and improve clinical effectiveness .Conclusion It’ s needed to improve the strategies of alternative dosing regimens for clinical practice .