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OBJECTIVE To provide a reference for the safe administration of patients with atrial flutter， atrial fibrillation， placenta praevia hemorrhage and thrombocytopenia-threatened abortion after the operation of congenital heart disease. METHODS Clinical pharmacists participated in the diagnosis and treatment of a patient with atrial flutter， atrial fibrillation， placenta praevia hemorrhage and thrombocytopenia-threatened abortion after the operation of congenital heart disease. Given the thrombocytopenia caused by enoxaparin sodium， pharmacists suggested to stop enoxaparin sodium and change it to fondaparinux sodium after a blood routine review. For the patient with fast heart rate and low blood pressure， pharmacists recommended to choose metoprolol and adjust the dosage according to the heart rate， and change furosemide to hydrochlorothiazide. Pharmacists recommended to continue using metoprolol regarding doctors’ plan to replace metoprolol with sotalol before cesarean section. For possible drug interactions in the patient， pharmacists recommended to closely monitor blood potassium and other indicators， and provided drug education. RESULTS The doctors adopted the advice of clinical pharmacists. The patient’s bleeding was controlled， the indicators were kept stable during hospitalization， the gestational week was extended smoothly， and the cesarean section was successfully performed. CONCLUSIONS By participating in the treatment of the patient with atrial flutter， atrial fibrillation， placenta praevia hemorrhage and thrombocytopenia-threatened abortion after the operation of congenital heart disease， clinical pharmacists formulate individualized medication plans for the patient based on adverse drug reactions， drug interactions and medication education， ensuring the safety and effectiveness of medication.
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Background: Placenta praevia refers to a placenta that is Inserted either completely or partially in the lower uterine segment. In placenta praevia, placenta is implanted in the lower uterine segment within the zone of effacement and dilatation of cervix, resulting in obstruction to decent of the Presenting part. The aim of this study is to find out the maternal and fetal outcome of Placenta praevia in term pregnancy. Material & Methods: This is an observational study. The study used to be carried out in the admitted patient’s Department of obstetrics and gynecology, Dhaka Medical College and Hospital, Dhaka, Bangladesh. In Bangladesh for the duration of the period from January 2013 to June 2013. The duration of the period from Data was entered in MS Excel and Statistical analysis was done using SPSS 24 version. Results: This study shows that Maternal age range was 18 to 45 years and the commonest age group of placentas previa was 25-29 years (60.0%). Four percent were between 20-24 years age group. Twenty percent were more than 35 years of age. Conclusion: The study subjects were selected only who were found high maternal morbidity and perinatal mortality which was 8% due to placenta preavia. So, the observed result of this study might not reflect the expected real outcome. In population therefore further prospective studies with a large sample should be carried out for comprehensive evaluation of placenta Preavia on maternal and neonatal outcome.
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A spontaneous rupture of the unscarred uterus in a primigravid patient is extremely rare and is associated with high perinatal and maternal morbidity and mortality. Study report a case of spontaneous rupture of an unscarred uterus at 36 weeks of gestation in a 22-years primigravid woman. Ultrasonography showed posterior low-lying placenta praevia with lower margin touching internal OS. Operative findings during emergent caesarean section revealed e/o 2 L of hemoperitoneum, uterus was bicornuate and pregnancy was in the right horn. There was fundal rupture of right horn measuring approximately 6-7 cm anteroposterior. Incision was taken on the lower part of right horn and placenta was seen on anterior wall. Baby delivered as breech after incising placenta. Postoperative recovery was uneventful. In, conclusion, bicornuate uterus may be an independent risk factor for uterine rupture, which can occur in primigravid patients and at any gestation.
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Background: Major degree placenta praevia is a serioushealth issue and is associated with high fetal-maternalmorbidity and mortality. Especially the central placenta praeviais one of the most dangerous states in obstetrics.Objective: The objective of the study is to investigate theoutcome of central placenta praevia and to determine area ofconcern which requires maximum focus to decrease theincidence.Materials and Methods: This cross sectional study wasconducted over a period of two years (from January 2018 toDecember 2019) in the department of Obstetrics andGynaecology at HFRCMCH, Dhaka, Bangladesh.Results: A total numbers of 2479 antenatal patients had beenexamined in this study. Out of 2479 antenatal patient1380(55.67%) were caesarean section delivery. Among them53(2.14%) were suffering placenta praevia. Out of 53 placentapraevia, 47 were central placenta praevia. In percentageanalysis it is 88.68%, which is too high. All the placenta praeviapatients were delivered by caesarean section. 37 weredelivered by elective caesarean section16 were delivered byemergency caesarean section. Among 16 emergencydeliveries, 8 were due to Severe P/V bleeding and rest 8 forlabour pain & fetal distress. Regarding the maternal outcome,no mortality occurred but 5 patients needed ICU care, 6patients needed hysterectomy and 5 patients had bladderinjury for which they needed bladder repair. Regarding theneonatal outcome, 16 babies needed NICU support. Amongthem 5 babies died.Conclusion: Placenta praevia, especially central placentapraevia is a major cause of both maternal and fetal morbidityand mortality. If the patient has previous H/O caesareansection it becomes more serious. By observing the outcome ofthese patients in our hospital, we can also correlate it withother studies. By this way we can also take measure todecrease the incidence of maternal and fetal morbidity andmortality.
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Background: With the globally emerging trend of Caesarean deliveries, there arises a more pressing matter of subsequent pregnancy outcomes with previous caesarean deliveries. Especially, the physiology of Placental localisation being a poorly understood phenomena, question arises, whether a previous caesarean scar can influence the site of placental implantation, subsequent migration and pregnancy outcome. The objective of present study is placental localisation and study of maternal and foetal outcome in previous caesarean delivery patients. Methods: A prospective longitudinal study on 100 previous caesarean patients was conducted over a period of 20 months at Department of obstetrics and gynaecology at JNIMS. Placental location was determined ultrasonographically between 28 to 42 weeks gestation, Patients followed up and feto-maternal outcomes analysed. Results: In most, placenta located fundo-anterior and fundo-posterior (30% each) and five (5%) patient reported placenta previa. The study suggests that maternal complications like postpartum haemorrhage (60% vs 6.3) and requirement for interventions (40% Vs 11.6%) were higher among praevia patients. Foetal complications like low Apgar (40% Vs 9.5%) were higher in patients with placenta praevia w.r.t. normal placentation. Low birth weight was 57 fold higher, Preterm birth 10.9 fold higher and NICU admissions were 1.7 fold higher among placenta praevia. Conclusion: A caesarean first birth is associated with increased risks of low lying placentation, previa and abruption, intraoperative blood loss, perioperative morbidity and increased operative time in subsequent pregnancy.
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Background: Placenta praevia is one of the serious obstetric problems with far reaching effects and a major cause of antepartum haemorrhage. The aim of the study was to evaluate the foetomaternal outcome of pregnancies with placenta praevia.Methods: The present study was a prospective case control study conducted in the Department of Obstetrics and Gynaecology, Lal Ded Hospital, Srinagar from August 2009 to October 2010.Results: Among the 100 cases of placenta praevia studied bleeding per vaginum was the most common presenting symptom. Major placenta praevia was more common (53%) than minor placenta praevia. 43% of the cases of placenta praevia delivered before 37 completed weeks as compared to only 6% in the control group. All cases of placenta praevia delivered by caesarean section. Maternal morbidity in terms of postpartum haemorrhage (32%), intraoperative bowel and bladder injury (2%) and intensive care unit admission (1%) was more in cases of placenta praevia. Foetal complications in terms of neonatal intensive care unit admission (19%), neonatal death (10%) and stillbirth (5%) were more in pregnancies with placenta praevia as compared to controls. 48% of patients with placenta praevia required transfusion of blood and blood products as compared to 4.5% among controls.Conclusions: There is a significant increase in maternal morbidity in pregnancies complicated with placenta praevia. Also, there is a higher incidence of foetal complications and neonatal death. Managing a case of placenta praevia is a challenge in present day obstetrics and it creates a huge burden on the health care system.
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Background: Antepartum haemorrhage (APH) as one of the major obstetric emergencies contributing greatly to maternal and fetal morbidity and mortality is of serious concern in the developing world. A retrospective analysis of the APH cases and evaluation of its impact on fetal and maternal outcomes was conducted.Methods: A retrospective study of cases managed between January 2013 and December 2014 at the University College Hospital Ibadan; all cases at a minimum of 28 weeks of gestation with antepartum bleeding were selected. Data was retrieved from the hospital records.Results: Around 5.8% prevalence rate of APH was documented during the study period with placental abruption and placenta praevia accounting for 46.8% and 39.2% of these cases respectively. Only 28.5% of cases were booked. Three-fifths of the women had anemia, 17.7% suffered hypovolemic shock, 33.9% also had primary PPH while 4 out of every 10 (39.8%) were transfused with blood. Seven out of every ten premature deliveries (prior to 34weeks gestation) were due to placental abruption with p value of <0.001. There were 2 maternal deaths (1%), 61 (31%) still births and 11 (5.6%) early neonatal deaths giving a perinatal mortality rate of 35.6%.Conclusions: Antepartum hemorrhage was associated with poor maternal and neonatal outcome in this study. There is need to improve on infrastructures, such as functional blood banks, appropriate antenatal care and referral system in our health facilities to be able to cope with increasing challenges of this obstetric hemorrhage.
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Background: Obstetric haemorrhage is the leading cause of preventable maternal mortality worldwide. One of the major contributors to obstetric haemorrhage is antepartum haemorrhage which is mainly caused by placenta praevia and abruptio placenta. The study aims to quantify the risk of placenta praevia based on the presence and number of caesarean sections and to assess other risk factors.Methods: This study was a prospective case control study conducted in the department of obstetrics and gynecology, Lalla Ded hospital, Srinagar, Jammu and Kashmir, India from August 2009 to October 2010. As per the inclusion and exclusion criteria of study 100 cases and 200 controls were selected and the association of placenta praevia with proposed risk factors was analysed statistically.Results: Present study showed that the risk of developing placenta praevia in future pregnancy increased steadily as the number of previous caesarean sections increased, risk being 2.1, 2.8 and 4 times with previous one, two and three caesarean deliveries respectively. Similarly, the risk of developing placenta praevia was more in women with history of previous abortion (risk being 2.8 and 6.5 times more in women with one and two abortions in the past). Previous dilatation and curettage and age more than 30 years also proved to be independent risk factors.Conclusions: To conclude advanced maternal age, previous abortion, dilatation and curettage and a history of previous caesarean section appear to increase the occurrence of placenta praevia. The study strongly emphasises the need to decrease the primary caesarean section rate.
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Background: Antepartum haemorrhage is one of the important causes of perinatal mortality and morbidity in India. The increased risk of perinatal morbidity and mortality in placenta praevia is due to preterm birth, low birth weight, birth asphyxia and neonatal sepsis. This is a retrospective study done over a period of 5years to determine the incidence, demographic features, risk factors, obstetric management, maternal mortality and morbidity, and perinatal outcome in women presenting with placenta praevia.Methods: This was a retrospective study done at Nil Ratan Sircar Medical College and Hospital over a period of five years starting from January 2016 to December 2017. Antenatal women with more than 28 weeks of gestational age with a complaint of painless vaginal bleeding or those diagnosed as having placenta praevia on routine ultrasound examination were included in this study and hospitalised. Among them cases of placenta praevia were 21.Results: There were21 cases of placenta praevia registered amounting to 0.23% incidence. The various antenatal complications seen associated with placenta praevia were severe anaemia (14.28%), coexisting PIH (4.76%), IUD (4.76%), IUGR/Oligohydraminos (4.76%). All the patients in the study had undergone caesarean deliveries. Perinatal morbidity studied as percentage of new-borns requiring resuscitation followed by NICU admission was 33.3%. Among the delivered patients of placenta praevia incidence of perinatal mortality was 23.8%. Prematurity (42.85%) contributed to most cases of perinatal mortality, followed by RDS (14.28%) and asphyxia (14.28%).Conclusions: In this study placenta praevia is seen more commonly in 28-34 weeks of gestation and patients mainly presented with a bout of bleeding eventually had preterm deliveries. Although vaginal deliveries are appropriate in selected cases of placenta paevia liberal use of caesarean section in well-equipped hospitals with availability of blood transfusion services have helped to lower complications.
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INTRODUCTION@#This study aimed to evaluate associated factors of blood transfusion for Caesarean sections in pure placenta praevia pregnancies.@*METHODS@#A case-control study was conducted among 405 pregnant women with placenta praevia who underwent Caesarean delivery between August 2004 and December 2013. 135 of the women received blood transfusions. Another 270 women who did not receive any blood transfusion were randomly selected and served as controls. Maternal demographic data, reproductive history, antepartum profiles and obstetric outcomes were compared between the two groups.@*RESULTS@#Women in the case group were significantly more likely to be multiparous, deliver at a gestational age of less than 37 weeks, have a prior Caesarean delivery, experience preoperative bleeding and anaemia, and have major and anterior placenta praevia (p < 0.05). Multivariate analysis demonstrated that significant, independently associated factors of blood transfusion were: previous Caesarean section (adjusted odds ratio [OR] 2.30, 95% confidence interval [CI] 1.36-3.90), anterior placenta praevia (adjusted OR 2.30, 95% CI 1.15-4.60), major placenta praevia (adjusted OR 2.39, 95% CI 1.34-4.22), preoperative bleeding of more than 250 mL (adjusted OR 6.11, 95% CI 2.35-15.90), preoperative anaemia (adjusted OR 2.31, 95% CI 1.34-4.00) and emergency Caesarean section (adjusted OR 2.14, 95% CI 1.08-4.22).@*CONCLUSION@#Previous Caesarean section, anterior placentation, major placenta praevia, preoperative bleeding of more than 250 mL, preoperative anaemia and emergency Caesarean section were independent factors that increased the risk of blood transfusion for Caesarean section in pure placenta praevia pregnancies.
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Resumen ANTECEDENTES La incidencia de acretismo placentario se ha elevado en países industrializados debido al incremento en la tasa de cesáreas. La ruptura prematura de membranas pretérmino se asocia con complicaciones en 3% de todos los embarazos. En la actualidad no existen publicaciones que documenten la atención médica de ambas alteraciones en conjunto. CASO CLÍNICO Paciente de 31 años, en curso del segundo embarazo (30.2 semanas de gestación), que acudió al servicio médico por salida de líquido transvaginal. Se confirmó la ruptura prematura de membranas pretérmino por cristalografía y determinación de microglobulina alfa 1 placentaria por tira reactiva Amnisure®. La valoración de los médicos del servicio de Medicina Materno-Fetal fue: placenta previa total, con lagunas placentarias y flujo turbulento, grosor miometrial menor de 1 mm y pérdida de la interfase deciduomiometrial. Después de comprobar el bienestar fetal se inició el tratamiento conservador de la ruptura prematura de membranas pretérmino. Se decidió finalizar el embarazo a las 31 semanas, debido a que se confirmó el inicio del trabajo de parto y actividad uterina normal; se efectuó cesárea-histerectomía sin complicaciones maternas. CONCLUSIÓN La placenta previa total con datos de acretismo, concomitante con ruptura prematura de membranas pretérmino, es una complicación poco común. Estas pacientes deben recibir tratamiento conservador y adecuada vigilancia materno-fetal. A pesar de los buenos resultados obtenidos en este caso, se requiere mayor evidencia para indicar el tratamiento conservador en estas pacientes.
Abstract BACKGROUND The incidence of placental accreta has increased in industrialized countries, due to the increase in the rate of cesarean sections. On the other hand, the premature rupture of membranes (PPROM), complicate approximately 3% of all pregnancies and is associated mainly with neonatal complications related to prematurity. At present, there is no documented evidence in the medical literature of the approach of both pathologies together. CLINICAL CASE 31-year-old woman at 30.2 weeks' gestation in her second pregnancy is admitted to the hospital with vaginal discharge. PROM is confirmed by fern-type crystallization and quantification of placental alpha macroglobulin-1 (PAMG-1) microglobulin by Amnisure® test strip. Medical assessment is performed by the maternal-fetal specialists, finding complete placenta praevia with the presence of vascular lacunae with turbulent lacunar flow, myometrium thickness < 1mm and loss of the clear space. Fetal well-being is confirmed and conservative management of PPROM is initiated. Obstetric delivery is conducted at 31 weeks of gestation with Caesarean section - Hysterectomy without complications. CONCLUSIONS The premature rupture of membranes in presence of placenta accreta is a rare complication. In this patients, conservative management is a suitable alternative, with an appropriate maternal and fetal surveillance. More evidence is required to indicate the conservative treatment in these patients.
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Background: Morbidly adherent placenta is a life threatening condition that requires multidisciplinary approach for management. Women presenting with placenta praevia have become the highest risk for abnormal placental adherence. Aim: Aim of the present study is to evaluate the efficacy of ultrasound and colour Doppler in the antenatal diagnosis of morbidly adherent placenta in women presenting with placenta praevia. Materials and methods: This was a prospective study conducted on patients with persistent placenta praevia who underwent transabdominal B mode and colour Doppler ultrasound evaluation in the third trimester during the period of May, 2015 to May, 2017. The imaging findings were compared with the final diagnosis at the time of delivery and at pathological examination. Results: In the present study, there were a total of 24 patients of morbidly adherent placenta with an incidence of 1.17 per 1000 pregnancies. Previous caesarean section with placenta praevia was the main risk factor for placental adherence. Conclusion: Ultrasound and colour Doppler have a fairly good sensitivity for prenatal diagnosis of placenta accrete.
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Background: The Objectives of the present study are to assess the risk factors associated with antepartum haemorrhage (APH), maternal morbidity & mortality due to APH and its perinatal outcome in APH. Methods: This study was an analytical retrospective study conducted at NIMS University and Medical College, Jaipur over the duration of one year from July 2013-July 2014 over 100 cases of APH admitted in the hospital. Results: Among the 100 cases of APH the types observed were, placenta praevia: 39, abruptio placenta: 31, indeterminate causes: 25 and extra placental causes: 5. Maternal mortality out of 39 cases of placenta praevia was 1 and out of 31 cases of abruptio placentae was again 1. Perinatal mortality was 10% in placenta praevia and 19% in abruptio placentae. Conclusipn: APH is a major cause of maternal and perinatal mortality & morbidity, which can be prevented, by early registration, regular antenatal care, early detection of high-risk cases, early referral, better blood bank and OT facilities, improved intra-operative and postoperative care and better neonatal intensive care.
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Peripartum or obstetric hysterectomy is the removal of the corpus uteri alone or with the cervix at the time of a cesarean section, or shortly after a vaginal delivery. It is a challenging though life-saving obstetric procedure it is associated with morbidity and mortality. The medical records of 20 patients who had undergone peripartum hysterectomy, between April 2015 to April 2016 (1 year), in a tertiary teaching hospital, King George Hospital, Visakhapatnam, covering north coastal Andhra Pradesh and surrounding districts of Odisha were reviewed retrospectively. The results were analyzed. Emergency peripartum hysterectomy is a most demanding obstetric surgery performed in very trying circumstances of life threatening hemorrhage. The indication for emergency peripartum hysterectomy in recent years has changed from traditional uterine atony to abnormal placentation. Antenatal anticipation of the risk factors, involvement of an experienced obstetrician at an early stage of management and a prompt hysterectomy after adequate resuscitation would go a long way in reducing morbidity and mortality. Prompt performance of peripartum hysterectomy before patient clinical conditions deteriorate is the main key to success and less postoperative complications.
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Objective To study the operative technique and effect of temporary balloon occlusion of the abdominal aorta for preventing intraoperative bleeding during cesarean for patients with pernicious placenta previa and placenta accreta. Methods Retrospective analysis was conducted on the intraoperative situation of forty-one cases and information of follow-up twenty-nine cases, which were pernicious placenta previa and placenta accreta and delivered in the First Affiliated Hospital of Zhengzhou University from May 1, 2013 to June 30, 2014. Diagnosis was confirmed by line of color Doppler ultrasound and MRI for all patients before operations. An interventional physician performed right femoral artery puncture and preset the abdominal aortic balloon catheter in the digital subtraction angiography operation room before cesarean. At the same time of fetal delivery, 10 ml normal saline was injected into the balloon immediately, which results in filling of the balloon and blocking of the aorta. According to the area and depth of placenta implantation and implantation or penetration of the posterior bladder wall, placenta separation, partial resection of the uterine wall and partial bladder resection and repair were performed correspondingly. Meanwhile, saline in the balloon was pumped out gradually until empty. Condition of placenta implantation, blood loss and blood transfusion volume during the operation, intraoperative and postoperative complications, the duration and dose of fetal radiation exposure, and Apgar score of neonates were analyzed. Results Among the 41 cases, penetrative placenta and implanted placenta were observed in five cases and 36 cases, respectively. The latter 36 cases including 28 cases of bladder posterior wall accreta and eight cases of bladder posterior wall penetration. For all cases, the average operation time was (68.5±15.3) min, the mean blood loss in the operation was (1 058±960) ml, among which eight received blood transfusion with an average of (600±400) ml, and the mean hospital stay was (8.2±2.3) d. Uteruses were reserved in all cases. The mean duration and dose of fetal radiation exposure was (8.1±3.6) s and (5.2±2.9) mGy, and the Apgar score of neonates was 8.7±0.5 at 1 min and 9.5±0.3 at 5 min, respectively. The patients were followed up until October 31, 2014. Among them, six were lost, six were still in puerperium, 18 were breast-feeding, and the menses of 11 had returned. Conclusion Preset abdominal aortic balloon catheter in pernicious placenta previa and placenta accrete patients might effectively reduce the blood loss during cesarean section as well as the risk of hysterectomy through temporary occlusion of the abdominal aorta.
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Objective To investigate the efficacy and safety of acute normovolemic hemodilu-tion for pregnant women with total placenta pravia and accreta.Methods Fifty-two pregnant women with placenta praevia and accreta were randomly divided into three groups.Groups A and B received ANH or AHH before the operation while group C received the normal treatment.The total blood loss,transfusion of allogeneic blood and preoperative and postoperative routine blood test were recor-ded;the infants’umblical artery blood samples were taken immediately after birth,and 1 min,5 min Apgar scores and the blood gas was analyzied.Results There were no significant difference in the general condition,operation duration,blood loss among the three groups;the transfusion of allogeneic blood in groups B and C were much more than group A (P <0.05);the postoperative hemoglobin and hematocrit and the count of plateletsin in group A were better than groups B and C (P <0.05),while there were no statistically difference between groups B and C;there were not only seldom difference in the Apgar scores of 1 min and 5 min,but also barely change in the blood gas analysis of umbilical ar-tery in new borns from the three groups.Conclusion ANH could play an important role in the pre-vention of postpartum hemorrhage without doing any harm to the mother and infant.
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Placenta praevia is a known obstetric condition that causes complications to mother and fetus. This study was done to evaluate the knowledge of placenta praevia amongst the obstetric patients. A cross sectional study was carried out in Hospital Ipoh, Perak among 323 antenatal and postnatal patients. Socio-demographic parameters (ie age, race, parity, occupation, educational level) and history of placenta praevia were studied in relation to level of knowledge and attitude towards placenta praevia. Twenty (6.2%) from 323 women had current or past history of placenta praevia. Three had history of placenta praevia while 17 had current placenta praevia with prevalence of 5.3%. The mean score of knowledge achieved by patients was 11.8of education and history of placenta praevia were found to have a relationship with level of knowledge regarding placenta praevia in all obstetric patients. There was a significant relationship between attitude of patients with current and history of placenta praevia to level of knowledge regarding placenta praevia. (p=0.037, <0.05). In conclusion, the knowledge and attitude towards placenta praevia among obstetric patients in Hospital Ipoh was better in those who had higher education status, white-collar occupation and currently pregnant with placenta praevia. which indicated overall poor knowledge. Occupation, level
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0.05). Significantly less amount of hemorrhage was found in women who delivered after 2 hours of massive hemorrhage than those within 2 hours (P