ABSTRACT
Objective To investigate the clinical application of serum miRNA-126,miRNA-155 detection in evaluation of plaque property in the carotid atherosclerotic(CAS)desease.Methods A total of 75 patients with the CAS from May 2015 to May 2017 in the Xianyang Central Hospital and Shiquan Country Chinese Traditional Medicine was chosen,consisted of 35 cases of vulvernable plaque group and 40 cases of stable plaque group.Meanwhile,39 cases of healthy physical examines at the same time were regarded as the control group.The expression levels of serum miRNA-126,miRNA-155 in the groups were detected using the real-time reverse transcription-polymerase chain reaction technique.The largest carotid artery plaque thickness(MAPT)and intima-media thickness(IMT)in the groups were measured using the cervical enhancement CT.Re-sults The results of MAPT and IMT were(3.27±1.01 mm,1.93±0.51 mm)in the vulvernable plaque group and(2.50 ±0.79 mm,1.60±0.26 mm)in the stable plaque group.The carotid artery largest plaque thickness and intima-media thick-ness was higher in the vulvernable plaque group than in the stable plaque group(t=9.76,7.86,P<0.01),and there were significant differenes between the two groups.The expression levels of serum miRNA-126and miRNA-155 were(0.22 ± 0.06,0.87±0.18)in the vulvernable plaque group,(0.50±0.12,0.47±0.10)in the stable plaque group and(0.90±0.19, 0.19±0.05)in the control group.MiRNA-155 expression levels significantly increased in stable plaque group and vulvern-able plaque group compared with in the control group,which increased in the vulvernable plaque group compared with in the stable plaque group,and miRNA-126 expression levels markedly decreased,the differences were statistically significant(F=119.3,102.9,P<0.01).In the vulvernable plaque group,miRNA-126 expression negatively correlated with miRNA-155(r=0.912,P<0.01).miRNA-126 expression levels were inversely associated with the carotid artery largest plaque thickness and the intima-media thickness(r=-0.913,-0.893,P<0.01).While miRNA-155 expression levels were positively corre-lated with them(r=0.899,0.907,P<0.01).Conclusion Serum miRNA-155,miRNA-126 detection can be applied to pre-diction of CAS plaques rupture,and may become a useful warning marker of ischemic stroke events.
ABSTRACT
Objective:To explore the thickness and property of different plaques in neck computed tomography angiography(CTA) for the patients with carotid artery stenosis, and analyze the correlation between them and cerebral infarction or transient ischemic attack(TIA).Methods: 160 patients with carotid artery stenosis were divided into observation group (103cases) and control group (57cases) according to whether they had occurred cerebrovascular events. Through CTA for neck of patients to measure the thickness of different plaques and CT value in mild plaque in the image, and analyze the characteristic of these plaques and the correlation between them and cerebral infarction or TIA.Results: The thickness of mild plaque of observation group was significantly thicker than that of control group while the situation of thickness of hard plague was just statistically adverse. The results of analysis of regression indicated that there was a certain correlation between thickness of mild plaque and cerebral infarction or TIA event (r=0.926,P<0.05). Conclusion: There was a certain correlation between thickness of mild plaque in neck CTA and cerebral infarction or TIA event in patients with carotid artery stenosis. In clinical practice, the occurrence of cerebral infarction or TIA event can be forecasted through measure thickness of mild plaque of carotid artery, so as to achieve the aims of prevention and treatment for them.
ABSTRACT
Objective:To explore the thickness and property of different plaques in neck computed tomography angiography(CTA) for the patients with carotid artery stenosis, and analyze the correlation between them and cerebral infarction or transient ischemic attack(TIA).Methods: 160 patients with carotid artery stenosis were divided into observation group (103cases) and control group (57cases) according to whether they had occurred cerebrovascular events. Through CTA for neck of patients to measure the thickness of different plaques and CT value in mild plaque in the image, and analyze the characteristic of these plaques and the correlation between them and cerebral infarction or TIA.Results: The thickness of mild plaque of observation group was significantly thicker than that of control group while the situation of thickness of hard plague was just statistically adverse. The results of analysis of regression indicated that there was a certain correlation between thickness of mild plaque and cerebral infarction or TIA event (r=0.926,P<0.05). Conclusion: There was a certain correlation between thickness of mild plaque in neck CTA and cerebral infarction or TIA event in patients with carotid artery stenosis. In clinical practice, the occurrence of cerebral infarction or TIA event can be forecasted through measure thickness of mild plaque of carotid artery, so as to achieve the aims of prevention and treatment for them.