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Background: Acute Lower Respiratory Tract Infection (ALRI) is an important cause of morbidity and mortality in the developing world. Pneumonia is a severe form of ALRI that cause over 2 million deaths annually among children younger than 5 years of age. About 19% of all deaths, pneumonia is the leading cause of child mortality. Malnutrition is known to be associated with greater intensity of lower respiratory tract infections, higher the frequency of complications, longer episodes of infections. This study is to assess the plasma zinc levels in normal and malnourished children with LRI aged 2 months to 5 years.Methods: This is a case control study, which was carried out in the Department of Paediatrics, Sree Balaji Medical College and Hospital, the study period is one year from July 2016 to July 2017. 100 children between 2 months to 5 years of age with LRI was included in the study and children less than 2 months and more than 5 years. 50 Children with normal nutrition were taken as controls and 50 children with moderate and severe malnutrition were taken as cases. Age and sex were matched among cases and controls. Blood samples were collected for zinc estimation in both the cases and controls. All children were investigated and treated as per the department protocol for the particular condition. All statistical procedures were performed using SPSS v 21.0.Results: In present study, 66% of children had normal zinc levels, 34% of children had low zinc levels. The mean zinc level in our cases was 54.84'18.31 and in controls was 76.84'15.2, which was statistically significant (p = 0.000). Mean plasma zinc levels with respect to age and sex were not significant.Conclusions: Total 34% of children with LRI had low plasma zinc levels. Plasma zinc level were significantly low in malnourished children than normally nourished children with LRI, which is one of the most important cause of high childhood mortality in developing countries.
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<p><b>Objective</b>To investigate the relationship between seminal plasma zinc alpha-2 glycoprotein (ZAG) and semen quality in obese males.</p><p><b>METHODS</b>This study included 130 obese male patients with idiopathic infertility Based on the concentration of seminal plasma ZAG, we divided the patients into three tertile groups: tertile 1 (T1, 73.45－97.15 μg/ml, n = 43), T2 (97.16－115.46 μg/ml, n = 44), and T3 (115.47－220.11 μg/ml, n = 43). We measured the concentrations of seminal plasma zinc (SPZ) and ZAG of the patients by ELISA, obtained the semen parameters, and analyzed the correlation of semen quality with the levels of SPZ and ZAG and the influence of obesity on SPZ, ZAG and semen quality.</p><p><b>RESULTS</b>The mean level of seminal plasma ZAG in the 130 obese male patients was (111.29 ± 26.50) μg/ml. There were statistically significant differences in sperm concentration and total sperm count among the three tertile groups (P < 0.05). The level of seminal plasma ZAG was correlated negatively with the body mass index (BMI), waist circumference (WC), sperm concentration and sperm count (P < 0.01), that of SPZ positively with BMI and WC (P < 0.05) but negatively with semen volume and the percentage of progressively motile sperm (P < 0.05). The level of serum ZAG, however, exhibited no correlation with SPZ, seminal plasma ZAG or semen quality. Obesity was found to be associated with significantly decreased concentration of seminal plasma ZAG and percentage of progressively motile sperm but remarkably increased level of SPZ (P < 0.05).</p><p><b>CONCLUSIONS</b>Obesity may induce the metabolic disorder of SPZ and ZAG, change the microenvironment of seminal plasma, and consequently affect semen quality.</p>
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Humans , Male , Body Mass Index , Infertility, Male , Metabolism , Obesity , Metabolism , Semen , Chemistry , Semen Analysis , Seminal Plasma Proteins , Sperm Count , Sperm Motility , Spermatozoa , Metabolism , Waist CircumferenceABSTRACT
Objective To investigate the influence of sperm morphology, sperm DNA fragmentation index and seminal plasma zinc on pregnancy outcome of in vitro fertilization and embryo transfer (IVF-ET).MethodsA total of 341 infertile couples underwent IVF-ET were selected from January 2016 to June 2016 in our hospital.Sperm morphology, sperm DNA fragmentation index and seminal plasma zinc level were compared according to pregnancy.ResultsIn 341 cases, 204 cases pregnancy and 137 cases of no pregnancy, with the pregnancy rate of 59.8%(204/341).Compared with the pregnancy group, the percentage of normal sperm percentage was low, the abnormal sperm index was higher in the non-pregnant group (P<0.05), the sperm DNA index was higher (P<0.05).The percentage of normal sperm, sperm DNA fragmentation index and seminal plasma zinc and pregnancy rate in sperm morphology were linear (P<0.05), And there was a negative correlation between abnormal sperm index and sperm DNA fragment index (P<0.05), and other indicators were positively correlated (P<0.05).ConclusionSperm morphology, sperm DNA fragmentation index and seminal plasma zinc levels may influence the outcome of IVF-ET.The above parameters can be used to predict pregnancy outcome of IVF-ET.
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Objective:To study the clinical effect of Bailing capsules in the treatment of diabetic impotence. Methods: Totally 136 cases of diabetic impotence were randomly divided into the observation group and the control group with 68 cases each. The obser-vation group was treated with Bailing capsules and the control group was with tadalafil tablets. The effect of the two groups was com-pared, and the changes in IIEF-5 score, serum testosterone ( T) and zinc ( Zn2+) before and after the treatment were studied as well. Results:The total effective rate of the observation group was 83. 82% while that of the control group was 67. 65%, and the difference was statistically significant (P0. 05), while IIEF-5 score was increased significantly (P0.05), while the serum testosterone (T) and IIEF-5 score were increased significantly in the observation group (P <0. 05). After the treatment, the symptoms in the two groups were both improved with increased IIEF-5 score, T and Zn2+, and the ob-servation group was with more obvious improvement. Conclusion:The effect of Bailing capsules in the treatment of diabetic impotence is promising, which is worthy of further study.
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Introduction: According to the National Nutrition and Health Survey of Argentina, 33 ,5 percent of women aged 14 to 49 years old could have alow zinc intake. Nevertheless, there is no information about the biochemical evaluation of zinc nutritional status in women at a reproductive age. Objective: To carry out an exploratory survey in order to study three biochemical parameters: zinc in plasma (ZnP), zinc in erythrocyte (ZnE) and the relationship zinc I Hemoglobin (Hb) in a group of female university students. Methods: The sample included 48 university students without pathologies who accepted to participate in the survey. Participants were evaluated by anthropometric measurements and Body Mass Index (BMI) was calculated. Fasting blood samples were obtained and plasma Zn and erythrocyte Zn levels were determined by atomic absorption spectrometry. Results: The group had a mean +/- standard deviation of 22,3 +/- 3,3 years and the anthropometric characteristics were: weight (kg)...
Introducción: en Argentina es muy escasa la información bioquímica respecto al estado nutritional con respecto al zinc (Zn) en mujeres en edad fértil. Según la Encuesta Nacional de Nutrición y Salud el 33,5 por ciento de las mujeres de 10 a 49 años presentan una ingesta inadecuada. Objetivos: La finalidad de este trabajo exploratorio fue estudiar el comportamiento de tres indicadores bioquímicos: Zn en plasma (ZnP), Zn en eritrocito (ZnE) y la relación Zn/Hb en un grupo de estudiantes universitarias. Métodos: La muestra estuvo constituida por 48 estudiantes universitarias clínicamente sanas, que aceptaron ser incluidas en el estudio. Se les realizó una evaluación antropométrica mediante la determinación del IMC. Se les extrajo sangre venosa en ayunas, determinando ZnP y ZnE por espectofotometría de absorción atómica. Resultados: El grupo estudiado presentó una edad promedio de 22.3 +/- 3.3 años y las siguientes características antropométricas (Media +/- DE): peso (kg): 56.0 +/- 6.8; talla (m): 1.62 +/- 0,05; IMC (kg/m2):21.3 +/- 2.2. Las estadísticas descriptivas: media +/- DE, (IC 95 por ciento) y...