The correlation of plasmacytomas variant translocation gene polymorphisms and diabetes nephropathy / 国际检验医学杂志

Objective To research the correlation of single nucleotide polymorphisms(SNPs) of Plasmacytomas Variant Translocation Gene(PVT1) and diabetes nephropathy.Methods To assay PVT1 SNPs (rs10808565,rs13447075,rs2648862,rs2720709,rs2648875) in two groups individuals with diabetes nephropathy and diabetes by MassARRAY system.Then analysis the results by statistical methods to evaluate the relationship between PVT1 SNPs and diabetes nephropathy.Results The distributions of SNPs of PVT1 (rs10808565,rs13447075,rs2648862,rs2720709,rs2648875) were all under the Hard-Weinberg equilibrium in two groups.Difference in PVT1 rs2648875 between two groups was statistically significant(P<0.05);and there were no significant differences in the others SNPs (rs10808565,rs13447075,rs2648862,rs2720709) between two groups.Conclusion PVT1 rs2648875 may contribute to the susceptibility of DN in chinese people and the others PVT1 SNPs (rs10808565,rs13447075,rs2648862,rs2720709) may not be Chinese susceptibility gene in DN.

Distinct Clinical Outcomes between Paramedullary and Extramedullary Lesions in Newly Diagnosed Multiple Myeloma

This retrospective study aimed to compare the clinical features of paramedullary lesions (PLs) and extramedullary lesions (ELs) of plasmacytomas at diagnosis, using positron emission tomography integrated with computed tomography, using glucose labeled with the positron-emitting radionuclide ¹⁸F (¹⁸F-FDG-PET/CT) in newly diagnosed multiple myeloma (NDMM), and to address their prognostic impact. Sixty-four patients with NDMM presenting ELs (n=22) and/or PLs (n=42) were included. Patients with ELs at initial presentation had unfavorable laboratory parameters of calcium and lactate dehydrogenase, a higher percentage of bone marrow plasma cells, and showed a trend toward advanced international staging system (ISS), compared to patients with PLs. Using X-ray imaging, high bone disease (HBD) was observed in 50% and 71% of patients with ELs and PLs, respectively. After a median follow-up of 29.2 months (range, 3.4–76.5 months) in survivors, patients with ELs had a significantly lower overall survival (OS) (p=0.033) than patients with PLs did, whereas the progression-free survival (PFS) did not differ significantly (p=0.818). However, the PFS after 1(st) progression was significantly worse in patients with ELs than in those with PLs (p=0.017). In the multivariate analyses, the negative impact of initial ELs on OS (p=0.033) was sustained. Our results demonstrated the different clinical features and outcomes of ELs and PLs in NDMM. Patients with initial ELs showed a shorter PFS after 1(st) progression, which translated into poor OS, providing insight into the different biological effect of ELs.

Multiple Solitary Plasmacytomas Presenting with Painful Erythematous Swelling of the Upper Eyelid

PURPOSE: To report a case of multiple solitary plasmacytomas that presented with painful erythematous swelling of the upper eyelid. The patient was diagnosed with extramedullary plasmacytoma, and was later found to have multiple metastases of the bone and soft tissue during follow up. CASE SUMMARY: A 55-year-old female patient presented with painful erythematous swelling of the left upper eyelid that persisted for 1 month prior to examination. Under suspicion of lacrimal gland inflammation, anti-inflammatory medication was started but the symptoms worsened. Orbital computed tomography showed that a mass infiltrated the left lacrimal gland. We performed incisional biopsy of the mass via eyelid crease incision. Based on histopathological examination, the mass was diagnosed as extramedullary plasmacytoma and the patient was treated with radiation. After a 10-month follow-up period, multiple metastases on the left parotid gland, thoracic spine, lumbar spine and pelvic bone were observed. Finally, we diagnosed the patient with multiple solitary plasmacytomas. CONCLUSIONS: We report the first case of multiple solitary plasmacytomas presenting with upper eyelid painful erythematous swelling. This condition should be considered for patients presenting with eyelid inflammation. In addition, long term follow up should be conducted to detect metastasis or recurrence.

Successful Treatment of a Gastric Plasmacytoma Using a Combination of Endoscopic Submucosal Dissection and Oral Thalidomide

We report a rare case of a gastric plasmacytoma treated with endoscopic resection and oral thalidomide therapy. A 70-year-old man was admitted to our hospital with indigestion. He had no specific medical history and unremarkable laboratory results. Gastroendoscopic findings revealed a focal, erythematous, flat elevated lesion in the anterior wall of the stomach antrum. A biopsy revealed atypical lymphocytes. Endoscopic submucosal dissection (ESD) with an insulation-tipped knife was performed 45 days after diagnosis. Radiological and hematological evaluations, including a bone marrow biopsy, were performed and showed no involvement of other organs. The patient was diagnosed with extramedullary gastric plasmacytoma. Follow-up gastroendoscopy was performed three times during a 2-year period and showed nonspecific ESD scarring. The patient's condition was found to be stable.

A few questions deserved special attention in diagnosis and treatment of multiple myeloma / 白血病·淋巴瘤

The key point of the diagnosis and therapeutic principle of the multiple myeloma (MM) have been well established due to the past decades of research and clinical practice.But the higher heterogeneity of the MM including the extramedullary plasmacytomas,systemic amyloidosis,venous thrombus and osteopathy that have made the disease more complicated and cause a lot of attention.

Clinical analysis of 18 cases with solitary bone plasmacytoma / 肿瘤研究与临床

Objective To improve the diagnosis level of solitary bone plasmacytoma (SBP) through analysing the clinical characteristics and therapy of this disease. Methods The clinical data of 18 cases were retrospectively analysis since 1999 in five hospitals, the clinical characteristics and therapeutic effect was summarized. Results The average age of 18 cases is 54.2 year (35-78), male were 1.6 times than female. 8 of 10 patients survived for 1-10 year after chemoradiotherapy, 2 of them progressed to multiple myeloma (MM)and died. 5 of 8 patients survived after only chemotherapy or radiotherapy. There were 11 cases of all patients in continue complete remission (CCS), the average CCS time was 47.3 months. Conclusion SBP is a type low-grade malignant tumor. Chemotherapy and radiotherapy is the main therapy. The patients can gain satisfactory prognosis with chemoradiotherapy, part of them can progress to MM.

A case of subcutaneous plasmacytomas of vessel puncture site in multiple myeloma after autologous stem cell transplantation / 대한내과학회지

We report a case of a 61-year-old man with Durie-Salmon stage IB, kappa light chain type, multiple myeloma (MM), who relapsed 6 months after autologous hematopoietic stem cell transplantation (HSCT). One month after vinblastin-mitoxantrone-dexamethasone chemotherapy, he presented with multiple subcutaneous plasmacytomas. These lesions were confined to previous vessel puncture sites such as subclavian central catheter insertion site, anchoring site and sampling site. He had no past history of plasmacytoma. After additional treatment of etoposide, cisplatin, solumedrol, cytosine arabinoside, the plasmacytomas decreased or disappeared. But blasts reappeared in his peripheral blood and the size of the plasmacytomas increased. This case represents the rare report of refractory MM presenting as multiple subcutaneous plasmacytomas with specific tropism to the sites of previous trauma.