A biologic study on toothash - plaster of paris mixture with absorbable collagen membrane in the treatment of peri-implant defects

Expression of transforming growth factor-1 in bone regeneration after the implantation of particulate dentin and plaster of paris

PURPOSE: This study was performed to investigate the expression of the transforming growth factor (TGF)-1, in a rat calvarium defect model using particulate dentin and/or plaster of Paris, and correlate the bone regeneration process with the histologic events. MATERIALS AND METHODS: Thirty-two Sprague-Dawley rats were divided into 4 groups of 8 animals each. A 1.0 cm-sized calvarial defects were made and the defect was filled with different graft materials as follows : Group A, the defects were filled with a mixture of particulate dentin and plaster of Paris with a 2:1 ratio; Group B, the defects were filled with plaster of Paris only; Group C, defects were filled with particulate dentin only; Group D, untreated control group. The animals were sacrificed by 1, 2, 4, 8 weeks after implantation. Excised wound tissues were processed for histology, immunohistochemistry and RT-PCR for the analysis of TGF-1 expression. RESULTS: Gene expression of TGF-1 was detected for all experimental groups. The highest gene expression was observed in the specimen taken at the first week after implantation in Group A. According to the histologic and immunohistochemical studies, TGF- 1 positive osteoblast-like cells were found in the early stage of healing after the implantation of particulate dentin and plaster of Paris. CONCLUSION: These findings suggest that TGF-1 may be related to new bone formation at the early healing process after the implantation of particulate dentin and plaster of Paris.

Effect on the bone regeneration of the mixture of human or bovine tooth-ash and plaster of paris in rats

EFFECT ON THE BONE REGENERATION OF THE MIXTURE OF HUMAN, BOVINE, PIG, RABBIT, OR DOG TOOTH-ASH AND THE PLASTER OF PARIS IN RATS

Evaluation of bone graft materials in the treatment of artificial bone defects around dental implant

Functional cast bracing as a treatment for humeral shaft fractures

Sixty-eight fractures of the shaft of the humerus were treated with a function cast brace consisting of a plaster of Paris individually-molded. A good alignment of fracture fragments is maintained and permitted rapid and uninterrupted osteogenesis. The early presumption of functional activity to the entire extremity resulted in condition conclusive to fracture healing and the prevention of contractures and joint stiffness secondary to prolonged immobilization which is fairly common in other forms of treatmentThere are no non-unions encountered, and morbidity is minimum.(Summary)

The Effect of Aloe, Gelfoam, Plaster on Bone Formation in applying to the bone defect / 대한구강악안면방사선학회지

PURPOSE: This study was to evaluate the effects of Aloe, Gelfoam, and Plaster of Paris on bone healing. MATERIALS AND METHODS: Four experimental defects were created for placement of the three materials in the right femur of dogs. One defect served as an empty control site. The evaluation was performed at 1-, 6-, and 12-weeks by light microscopy and NIH image program. RESULTS: Radiographic and Histologic examinations showed new bone formation in the presence of Aloe, Gelfoam, and Plaster of Paris and similar bone healing reactions. CONCLUSION: On the basis of these findings, it was concluded that Aloe, Gelfoam, and Plaster of Paris may be adequate agents for use in bone procurement.

Antibiotic loaded Plaster of Paris as a Prevention of Experimental Osteomyelitis in Rats / 대한정형외과학회잡지

Plaster of Paris is an effective ancillary treatment in the surgery of infected cavities in bone. It is well tolerated and spontaneously absorbed over the period of weeks to months, being replaced by bone of normal architecture. When the antibiotics incorporated into plaster of Paris, the antibiotics are capable of prolonged local release in bactericidal concentrations. Therefore it is proposed that antibiotics loaded plaster of Paris might be a simple adjuvant technique after good surgical debridement for the treatment of bone infection. The authors carried out an experiment to study the effect of plaster of Paris containing antibiotics for a prevention of experimental osteomyelitis, using 45 rats, which were divided into 3 groups. In the Group 1, a defect was made at the proximal metaphysis of the tibia, inoculated by Staphylococcus aureus sensitive to Cephradine and Tobramycin and then filled with plaster of Paris pellet. In the Group 2, a defect was filled with Cephradine loaded plaster of Paris pellet. In the Group 3, a defect was filled with Tobramycin loaded plaster of Paris pellet. Then we observed the healing process of the bone defect in the point of view of the gross findings, radiologic findings and histologic findings at 4th, 8th and 12th week after operation. The results of this study were as follows:l. In the control Group;all 30 cases were infected. 2. In the Group 2;only 4 of 30 cases were infected. 3. In the Group 3;all 30 cases were not infected. 4. The plaster of Paris filled into the defect was absorbed continuously and stimulated the new bone formation.

An In-vitro Experimental Study on Antibacerial Effects of Antibiotic-mixed Plaster of Paris Pellets / 대한정형외과학회잡지

Various kinds of bone cements mixed with antibiotics have been widely used for treatment and prevention of infections, especially combined with bone defects. But bone cements have some disadvantages in that they are rather expensive and capable of incurring some complications such ss fibrosis of surrounding soft tissue or local erosion of bone, and furthermore, they must be removed after infection is controlled for bone graft to fill up the defects because they do not have properties of osteoconduction or osteoinduction. So we have come to the idea of using theoretically advantageous plaster of paris to take place of bone cements, and performed in-vitro experiment upon the effectiveness of plaster of paris pellets containing antibiotics, then obtained good results comparable to those from many experimental studies using bone cements. By this, we think that it would be possible in the future to treat and prevent infections supervening bone defects with plaster of paris mixed up with antibiotics. The results are as follows : 1. Sustained release of large amount of antibiotics from plaster of paris enough to exert inhibitory activity on abcterial growth, and there was a direct relationship between concentrations of eluted antibiotics and diameters of inhibitory zones. 2. Tobramycin was capable of inhibiting the growth of S. aureus, E. coli, and Ps. aeruginosa for 7 days at maximum. 3. Cephradine inhibited the growth of S. aureus and E. coli but did not affect that of Ps. aeruginosa. 4. The maximum antibacterial activity wss reached within first 24 hours from the start of elution of antibiotics from plaster of paris.

EXPERIMENTAL AND CLINICAL OBSERVATIONS ON THE PARTICULATE PLASTER OF PARIS IMPLANT AFTER CY-STECTOMY OF THE JAW / 第二军医大学学报

This report describes the participate plaster of Paris implant into the cystic cavity after cystectomy of the jaw in 18 cases.It was found that the plaster of Paris is one of the satisfactory soluble alloplastic materials and may promote new bone formation with no harmful reaction.The prevention of complications.and the surgical procedure are also discussed.

EFFECTS OF PLASTER-OF-PARIS PARTICULATE IMPLANTS IN MANDIBULAR BONE CAVITY: AN EXPERIMENTAL STUDY / 第二军医大学学报

This paper describes the experimental research on effects of plaster-of-Paris par-ticulate implants in mandibular bone cavity . Eighteen animals used in this experiment were divided into Groups A and B.Group A consisted of 9 rabbits and Group B, 9 dogs.In all the animals the right side of the mandible served as the experimental side and the left side, the control one.They were sacrificed for examination at 1, 3, 6 months after surgery. The experimental results show that the plaster-of Paris particulate implants in mandibular bone cavity were safe, tissue tolerant, absorbable and stimulative to bone formation.