Apheresis in Korean Red Cross Nambu Blood Center / 대한수혈학회지

BACKGROUND: The yields of plateletpheresis products are important to meet standard platelet transfusion doses. The use of single donor platelets (SDPs) has been increased substantially worldwide. Korean Red Cross decided to supply and started collection of SDPs since January, 2000. This study evaluates platelet yields of plateletpheresis and plasmapheresis of Korean Red Cross Nambu blood center. METHODS: The records for SDPs collected by Amicus(TM) (Baxter, Deerfield, IL, USA), MCS+ (Haemonetics, Braintree, MA, USA) and Trima (Gambro BCT, Lakewood, USA) between Jan. 2005 and Nov. 2005 were evaluated. The records for plasma collected by Autopheresis-C(TM) (Baxter,Deerfield, IL, USA), MCS(TM), PCS 2 (Haemonetics, Braintree, MA, USA) between Jan. 2005 and Nov. 2005 were also evaluated. RESULTS: Platelet yields of SDP less than 3 x 10(11) accounted for 6.45% of all collections. The rate of SDPs which platelet yields less than 3 x 10(11) collected by AMICUS is 4.84%, MCS+ is 7.72%, TRIMA is 7.01%. The rate of plasmapheresis products under the criteria is 0.7%. Plasma collected with Autopheresis-C(TM) made a concern about break down of filtration pore and occuring of hemolysis during apheresis procedures. CONCLUSION: Platelet yields less than 3 x 10(11) accounted for 6.45% of all collections. The rate of plasmapheresis products under the criteria is 0.7%. This study demonstrated that qualfied management and thorough understanding of the plataletpheresis technology are necessary to increase productivity of SDPs with platelet yields 3x1011 or over.

Plateletpheresis yields: comparison of Baxter Amicus, Haemonetics MCS and Gambro Trima / 대한수혈학회지

BACKGROUND: The plateletpheresis yields are important to meet standard platelet transfusion doses and single donor platelets (SDPs) with fewer than 3.0x1011 can not be issued without approval from hospitals according to the regulations of Korea Red Cross blood center. This study evaluates platelet yields and plateletpheresis parameters of three different cell separators. METHODS: We used Amicus (Baxter, Deerfield, IL, U.S.A.), MCS+ (Haemonetics, Braintree, MA, U.S.A.) and Trima (Gambro BCT, Lakewood, U.S.A.) and collected a total of 2,303 units of leukocyte-reduced SDP(LRSDP). All separators were set up to target a platelet yield of 3.2x1011 and parameters were recorded for each collection. All units were divided into group 1(optimal platelet counts/unit) by platelet yields and separators. RESULTS: Three cell separators did not show any differences in the mean values of platelet yields. SDPs with 3.0x1011 or over were 87%, 91% and 87%, respectively. SDPs with more than optimal platelet counts per unit were 2%, 1% and 2%, respectively. SDPs collected by Trima had significantly higher values for pre-platelet count, total processing blood volume and used ACD volume. SDPs collected by MCS+ showed significant differences between groups in evaluated parameters including longer collecting time. CONCLUSION: All three separators provided satisfactory platelet yields with no significant differences among them. But platelet yields less than 3.0x1011 accounted for 9-13% of all collections. This study demonstrated that qualified management and thorough understanding of the plateletpheresis technology are necessary to increase productivity of SDPs with 3.0x1011 or over. It is also necessary to introduce new regulations and criteria for platelet yields, e.g. the yield-based pricing system.