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Objective To investigate the clinical effect of Compound Danshen Dripping Pill (CDCP) combined with polyene phosphatidyl choline in the treatment of nonalcoholic fatty liver disease.Methods Patients with nonalcoholic fatty liver disease (116 cases) treated in Xi'an Medical University Affiliated Baoji Hospital from January 2012 to December 2015 were selected and divided into two groups randomly.Control group was treated with CDDP,and observation group was treated with CDDP combined with polyene phosphatidyl choline,the two groups were treated for 3 months.The clinical efficiency of two groups was compared.The following indicators were detected before and after treatment respectively,such as liver function indicators:aspartate aminotransferase (AST),alanine aminotransferase (ALT),γ-glutamyltransferase (γ-GT) and total bile acid (TBIL);blood lipid indicators:total cholesterol (TC),triacylglycerol (TG);and liver triglyceride fibrosis indicators:laminin (LN),hyaluronic acid (HA),procollagen Ⅲ (PC Ⅲ),and type Ⅳ collagen (Ⅳ-C),and carried on the upper abdomen CT plain scan,the liver/spleen CT ratio were calculated.Results After treatment,the effective rate of the observation group was 91.4％ (53/58),significantly higher than that of the control group 72.4％ (42/58) (P ＜ 0.05).After treatment,the levels of AST,ALT,γ-GT,TBIL,TC and TG in two groups were decreased significantly compared with the same group before treatment and lower in the observation group (P ＜ 0.05),and liver/spleen CT ratio was increased significantly and higher in the observation group (P ＜ 0.05).After treatment,the levels of LN,PC Ⅲ,Ⅳ-C and HA in two groups were decreased significantly compared with the same group before treatment and lower in the observation group (P ＜ 0.05).Conclusion CDDP combined with polyene phosphatidyl choline can significantly improve the liver function and liver fibrosis in patients with nonalcoholic fatty liver disease,and lower blood lipid,which has high clinical value.
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Objective: To analyze the compatibility taboo of polyene phosphatidyl choline injection with several kinds of commonly used clinical drugs.Methods: The medical literatures on the compatibility taboos of polyene phosphatidyl choline injection with several commonly used drugs were retrieved and statistically analyzed.Results: After the compatibility of polyene phosphatidyl choline injection with vitamin C, raceanisodamine injection, doxofylline and sodium chloride injection,ambroxol hydrochloride injection,ondansetron hydrochloride injection and the other commonly used drugs, physical and chemical reactions happened in varying degrees.Conclusion: Polyene phosphatidyl choline injection has compatibility taboos with a variety of commonly used drugs.
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Objective To observe the expression of insulin-like growth factor 1 (IGF-1),insulin-like growth factor binding protein 3 ( IGFBP-3) in rats’ serum with non-alcoholic fatty liver disease ( NAFLD) and the impact of Polyene phosphatidyl choline .Methods NAFLD model was induced by feeding the SD rats with a high-fat diet, with Polyene phosphatidyl choline to intervene .Observe the pathological changes of the rats ’ liver tissue dynamically after HE staining . Detect the contents of IGF-1,IGFBP-3 in serum dynamically through the immuno radio metric assay ( IRMA).Results There were no obvious exception of the liver tissue pathology in the normal group at each time .With the extension of a high-fat diet,the liver tissue of the model group increased on fatty change ,the degree of inflammation ,the balloon sample change , the NAFLD activity score at 4,8,12weeks.IGF-1,IGFBP-3 in serum were decreased significantly ,and the model set was significantly lower than the normal group at the same phase .After the application of polyene phosphatidyl choline ,the degree of rat liver tissue inflammation and the NAFLD activity score were reduced significantly when compared with model group , while the level of IGF-1,IGFBP-3were significantly higher .Conclusion The levels of IGF-1,IGFBP-3 in the rats’ serum reduce in the development of non-alcoholic fatty liver disease .
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Objective:To observe the efficacy of polyene phosphatidyl choline combined with Hugan tablets in the treatment of drug-induced liver injury. Methods:Totally 80 cases of drug-induced liver injury were randomly divided into the observation group (40 cases )and the control group(40 cases). The observation group was given polyene phosphatidyl choline injections 697. 5mg+5%glucose injections 250ml,ivd,qd,combined with Hugan tablets 1. 44g,po,tid,the control group was given polyene phosphatidyl choline injections 697. 5mg+5%glucose injections 250ml,ivd,qd,and the symptomatic treatment in the two groups was the same. The two groups were treated for 20d. Alanine aminotransferase ( ALT), aspartate aminotransferase ( AST), total bilirubin ( TBIL), glutamyl transpeptidase(GGT) and alkaline phosphatase(ALP)were detected respectively before and after the treatment, and the therapeutic effects were compared between the two groups. Results: After the treatment,the total effective rate in the observation group was 97. 5%,which was significantly higher than that in the control group(P <0. 01),Symptoms,signs and biochemical indices in the two groups were improved obviously. The decrease of ALT,AST and GGT in the observation group after the treatment was obviously lower than that in the control group(P<0. 05). Conclusion: Polyene phosphatidylcholine injections combined with Hugan tablets in the treatment of liver injury is better than polyene phosphatidyl choline, which is worthy of clinical application.
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OBJECTIVE:To observe the therapeutic efficacy and safety of polyene phosphatidyl choline and atorvastatin in the treatment of alcoholic liver disease. METHODS:112 patients with alcoholic liver disease were randomly divided into control group (n=56)and treatment group(n=56). Both groups were given a cure for alcoholism,vitamin and polyene phosphatidyl choline (465mg,qd,i.v. gtt)therapy. Treatment group were additionally treated with torvastatin(10 mg,po)once a day before bed for 4 weeks. Clinical symptoms,signs,liver function,blood lipid changes of two groups before and after treatment were observed. RESULTS:Treatment group was superior to control group in respect of clinical symptoms,signs,liver function and blood lipid changes(P