ABSTRACT
Objective To assess the efficacy of bowel preparation and tolerability, adverse reactions, re-examination willingness in different dose and taking method of compound polyethylene glycol electrolyte solution (PEG) before colonoscopy. Method This was a prospective, randomized, single-blind trial. From March 2017 to April 2017, 200 patients underwent colonoscopy were randomized to 3 group as 2L group (n = 60), (2+1)L group (n = 75) or 3L group (n = 65). The primary outcome was preparation quality from procedure photos using the Boston Bowel Preparation Scale. Additional aims of this study were to compare patient's tolerability, side reaction, and the re-examination willingness. Results Over the course of the study we identified 184 eligible outpatients to participate in the study, including 2L group (n = 58), (2+1)L group (n = 70) and 3L group (n = 56). The average of BBPS scores for (2+1)L group and 3L group were higher than 2L group's score (P < 0.05). The scores according to BBPS of the (2+1)L group and 3L group were similar (P > 0.05) but the score of right colon of 3L group was higher than (2+1)L group (P < 0.05). The tolerability, adverse reactions and re-examination willingness of 2L group and (2+1)L group were better than 3L group (P < 0.05). Conclusions The (2+1)L PEG preparation for colonoscopy had higher efficacy than 2L PEG, reduced the adverse reaction of patients and improved the tolerance and the re-examination willingness.
ABSTRACT
Colonoscopy has been accepted as the standard method for evaluation of colon and rectum,its success rate depends on the quality of bowel preparation. Aims:To evaluate the cleanliness and tolerance of fractionated dose versus single dose polyethylene glycol electrolyte solution( PEG-ES) bowel preparation regimens for colonoscopy. Methods:A total of 427 consecutive asymptomatic individuals undergoing colorectal cancer screening were enrolled and randomly assigned into 2 groups. Subjects in group A drank 1. 5 L PEG-ES on the eve and 4 hours before colonoscopy, respectively;subjects in group B received a single dose of 3 L PEG-ES 5 hours before colonoscopy. Score and degree of Boston bowel preparation scale(BBPS)and PEG-ES related adverse effects of the two groups were assessed and compared. Results:There were no significant differences in gender,age and cecal insertion rate between group A and group B(P ﹥ 0. 05). Score of BBPS was significantly higher in group A than in group B(P ﹤0. 01). Both regimens met the requirement of conventional colonoscopy,however,the cleanliness of colon was graded as excellent in more subjects of group A( P ﹤ 0. 01),and less subjects of group A complained PEG-ES related nausea(P ﹤0. 05). Logistic regression analysis revealed that the PEG-ES drinking pattern was associated with cleanliness of colon and occurrence of nausea( P ﹤ 0. 05). Conclusions:Fractionated dose PEG-ES regimen provides a better colonic cleansing quality and tolerance for bowel preparation of colonoscopy,which is superior to that of single dose regimen.