ABSTRACT
ABSTRACT Polymeric films associating different concentrations of Eudragit(r) FS 30 D (EFS) and chondroitin sulfate (CS) were produced by casting for the development of a new target-specific site material. Formed films kept a final polymer mass of 4% (w/v) in the following proportions: EFS 100:00 CS (control), EFS 95:05 CS, EFS 90:10 CS and EFS 80:20 CS. They were analyzed for physical and chemical characteristics using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and Raman spectroscopy. Furthermore, they were characterized by their water vapor permeability and degree of hydration at different conditions simulating the gastrointestinal tract. No chemical interactions were observed between CS and EFS, suggesting only a physical interaction between them in the different combinations tested. The results suggest that EFS and CS, when combined, may form films that are candidates for coating processes seeking a modified drug delivery, especially due to the synergism between pH dependency and specific biodegradability properties by the colonic microbiota. EFS 90:10 CS proved to be the most suitable for this purpose considering hydration and permeability characteristics of different associations analyzed.
Subject(s)
Polymers/adverse effects , Chondroitin Sulfates/analysis , /classification , Spectrum Analysis, Raman/instrumentation , Microscopy, Electron, Scanning/instrumentation , Administration, Oral , Spectroscopy, Fourier Transform Infrared/instrumentation , Drug LiberationABSTRACT
The objective of the present study was to evaluate the effect of different plasticizers on the ethylcellulose coatings of capsules and its timed release characteristics. Various plasticizers such as dibutyl phthalate (DBP), triacetin (TA), glycerol, triethyl citrate (TEC), polyethylene glycol-4000 and polyethylene glycol-6000 (PEG) were studied. The physicochemical properties of the casted polymeric films such as mechanical resistance, water uptake and dry weight loss were determined. Also the type and concentration of plasticizer on timed release of the capsule was studied. The drug release was found to be strongly dependent on the type of plasticizer and was in the order of GY>TA>PEG 6000>PEG 4000>TEC>DBP. Capsules coated with hydrophobic DBP (5%) showed good release with a lag time of 6 ± 0.5 h. DBP provided mechanically resistant coatings on the capsule and remained within the polymeric films without leaching upon exposure to the release media which helped in maintaining the lag time.