ABSTRACT
Objective To systematically assess the clinical effect and safety of Poractant Alfa Injection and ambroxol hydro-chloride in treating neonatal respiratory distress syndrome (NRDS) .Methods The home and abroad randomized controlled trials ( RCTs ) on the comparison of clinical effect and safety of Poractant Alfa Injection and ambroxol hydrochloride in treating NRDS were retrieved by computer .The literature quality was evaluated by the modified JADAD scale .Rev Man5 .3 .1 software was used for conducting the meta analysis .Results Twenty-four RCT were included .The meta analysis results showed that compared with ambroxol hydrochloride ,Poractant Alfa Injection for treating NRDS could more significantly increase the PH value (MD= -0 .02 , 95% CI:-0 .03- -0 .01 ,P<0 .01) ,increased the PaO2 value(MD= -2 .92 ,95% CI:-4 .59 - -1 .26 ,P<0 .01) ,decreased the PaCO2 value (MD=0 .95 ,95% CI:0 .12-1 .77 ,P=0 .02) ,reduced the FiO2 value(MD=0 .03 ,95% CI:0 .01-0 .05 ,P<0 .01) ,en-hanced the Pa O2/FiO2 ratio (MD= -7 .62 ,95% CI:-10 .87 - -4 .37 ,P<0 .01) ,reduced the short term complications (RR=1 .67 ,95% CI:1 .31-2 .12 ,P<0 .01) and long-term complications (RR=2 .85 ,95% CI:1 .14-7 .07 ,P=0 .02) ,shortened the hos-pitalization days (RR=3 .03 ,95% CI:0 .94 -5 .11 ,P<0 .01) as well as decreased the mortality rate (RR=1 .96 ,95% CI:1 .15-3 .34 ,P=0 .01) .However ,there were no statistical differences in the durations of continuous positive airway pressure (CPAP) me-chanical ventilation ,oxygen inhalation time ,time of clinical symptom outcome ,incidence rate of NRDS and total effective rate of treatment between the two groups .Conclusion Currently published evidences show that Poractant Alfa Injection is superior to am-broxol hydrochloride in treating NRDS ,however ,due to limited number of included RCD and medium quality ,the conclusion needs large scale and multicenter RCT verification .
ABSTRACT
Objective To observe and analyze the Poractant Alfa Injection treatment of neonatal respiratory distress syndrome and the effect of nursing. Methods A total of 60 cases of neonatal respiratory distress syndrome were used as the research object, the patients were divided into two groups of test analysis, study group and control group of 30 patients, two groups of children were using Poractant Alfa Injection for treatment, the control group with routine nursing, the study group using humanized nursing, nursing effect comparison. Results After treatment and nursing, blood gas monitoring index in the study group, mechanical ventilation parameters were better than the control group, P<0.05, the difference was statistically significant. At the same time the study group with family satisfaction with care and compared with the control group increased significantly (P<0.05). Conclusion For children with neonatal respiratory distress syndrome during the treatment by Poractant Alfa Injection, The effect of humanistic nursing is more obvious, which can effectively improve the clinical symptoms of children, and the implementation of nursing intervention can also improve the satisfaction of the families of the children and the effect of treatment.
ABSTRACT
Objective To observe and analyze the Poractant Alfa Injection treatment of neonatal respiratory distress syndrome and the effect of nursing. Methods A total of 60 cases of neonatal respiratory distress syndrome were used as the research object, the patients were divided into two groups of test analysis, study group and control group of 30 patients, two groups of children were using Poractant Alfa Injection for treatment, the control group with routine nursing, the study group using humanized nursing, nursing effect comparison. Results After treatment and nursing, blood gas monitoring index in the study group, mechanical ventilation parameters were better than the control group, P<0.05, the difference was statistically significant. At the same time the study group with family satisfaction with care and compared with the control group increased significantly (P<0.05). Conclusion For children with neonatal respiratory distress syndrome during the treatment by Poractant Alfa Injection, The effect of humanistic nursing is more obvious, which can effectively improve the clinical symptoms of children, and the implementation of nursing intervention can also improve the satisfaction of the families of the children and the effect of treatment.
ABSTRACT
Objective To investigate the effect of poractant alfa injection(PS) on neonatal respiratory distress syndrome(NRDS).Methods According to the digital table,80 cases of NRDS were randomly divided into the control group (40 cases) and the treatment group (40 cases).Both two groups were treated by mechanical ventilation and conventional symptomatic,supportive treatment.The treatment group was given PS intratracheal injection,the control group was given 0.9％ sodium chloride injection intratracheal injection.The clinical symptoms,blood gas analysis and the improvement of X-ray chest film were dynamicly observed,the clinical efficacy was compared between the two groups.Results In the treatment group,PaO2 returned to ＞ 60mmHg time,PaCO2 returned to ＜ 50mmHg time,mechanical ventilation time were (2.13 ± 0.21) h,(12.56 ± 0.11) h,(18.2 ± 0.33) h,which were shorter than those in the control group [(12.41 ± 0.13) h,(89.87 ± 0.26) h,(76.13 ± 0.65) h,t =2.632,2.403,1.895,all P ＜ 0.05] ;39 cases in the treatment group were cured(97.5％),30 cases in the control group were cured(75.0％),the difference of cure rate between the two groups was statistically significant(x2 =8.53,P ＜ 0.05).The incidence rate of comnplications such as pulnonary hemorrhage,pneumothorax,intracranial hemorrhage in the treatment group was 7.5％,which was significantly lower than 32.5％ in the control group (x2 =7.81,P ＜ 0.05).Conclusion PS in the treatment of NRDS has obvious curative effect and less adverse reactions,it can be used in clinical application.