ABSTRACT
Pyk2(Proline-rich tyrosine kinase 2) is an important member of focal adhesion kinase family. Pyk2 is highly ex-pressed in the central nervous system and the hematopoietic sys-tem . Pyk 2 can trigger a variety of SH 2 domain-containing pro- teins to phosphorylate their substrates, thus it can participate in the regulations including ion channel activation, stress response, cell adhesion, cytoskeleton reorganization, vesicle transport and so on. Through the regulations above, the ability of cell migra-tion, survival, proliferation changes accordingly, suggesting that Pyk2 in many important regulatory processes may become a tar-get for clinical effects. Current drug development for Pyk2 main- ly focuses on cancer, osteoporosis and immune response. This review illustrates the domain structure, regulatory mechanisms, potential drug targets, and the drug development of Pyk2 based on the above three fields, which will provide a theoretical basis for clinical treatment.
ABSTRACT
La interacción de los conceptos caerse y dejarse caer en la tercera edad, así como el conocimiento de las causas y consecuencias de uno y otro, resultan esenciales en la prevención de las fracturas poróticas. El objetivo de este trabajo es mostrar los distintos factores que al actuar sobre el sistema osteomioarticular conducen a caerse y provocar estas fracturas, y qué se debe hacer para evitarlas. Se concluye que no caerse ni dejarse caer, no es una meta sino elementos del viaje de la vida para hacernos, aunque viejos, más libres(AU)
The interaction between the concepts to drop and let yourself drop in the elderly as well as the knowledge of the causes and consequences of these facts are fundamental in the prevention of porous fractures. Therefore, the aim of this work is to show the different factors that, acting on the osteomyoarticular system, lead to drops and cause these types of fractures and what to do to avoid them. It is concluded that, neither drop nor let yourself drop, is not a goal but elements of our life journey that make us be older, but freer(AU)
L'interaction des concepts «tomber¼ et se négliger chez les personnes âgées, ainsi que la connaissance des causes et des conséquences d'un concept et d'un autre, sont associées à la prévention des fractures ostéoporotiques. Le but de ce travail est donc de montrer les différents facteurs conduisant aux chutes et aux fractures, et comment les éviter. On conclu que la notion «ne pas tomber ni se négliger¼ n'est pas un but, mais des éléments essentiels nous rendant plus indépendants au cours de la vie(AU)