Post-COVID-19 unilateral upper lip numbness: A case report

@#This is a case of a 63-year-old female with post-COVID-19 unilateral upper lip pain and numbness. Neurologic examination did not reveal any deficits other than deficits on pinprick in the maxillary division (V2) of the left trigeminal nerve. Brain neuroimaging showed signs of acute inflammation of the left maxillary sinus. Neuropraxia of the infraorbital nerve, a branch of the trigeminal nerve, was the diagnosis considered. Reports on trigeminal neurosensory changes following acute sinusitis are few, and isolated trigeminal neuropathy is rare except in cases of dental disorders. Up to this writing, there have been no reports on post-COVID-19 unilateral upper lip numbness and pain. This study will also serve as a concise review on the correlative neuroanatomy of the trigeminal nerve.

Proceso formativo del estudiante de Medicina en la detección de secuelas discapacitantes pos-COVID-19 / Training process of the medical student in the detection of post-COVID-19 incapacitating sequelae i: en

Introducción: En el proceso de capacitación continua de los estudiantes de Medicina resulta necesario incorporar temas de actualidad; asimismo, es importante conocer los problemas para buscar soluciones con el apoyo de la ciencia. Objetivo: Diagnosticar el proceso formativo del estudiante de Medicina en cuanto a la detección de secuelas discapacitantes pos-COVID-19. Métodos: Se realizó un estudio observacional, descriptivo y transversal, con enfoque cualitativo, de 20 estudiantes del quinto año de la carrera de Medicina, pertenecientes a la Universidad de Ciencias Médicas de Camagüey, durante su estancia por la asignatura Salud Pública, desde julio hasta diciembre del 2022. Para tal propósito se diseñó y aplicó un instrumento evaluativo con dimensiones e indicadores. Resultados: Se halló que 50,0 % de dichos estudiantes se ubicó en el rango de edad de 21-26 años, mientras que 65,0 % correspondió al sexo femenino. La dimensión cognitiva fue evaluada de mal, pues 3 indicadores, de los 4 que la integraban, recibieron esa calificación; del mismo modo sucedió con la dimensión instrumental. En cambio, la dimensión actitudinal y sus 2 indicadores fueron calificados de bien. Conclusiones: Existieron insuficiencias en el proceso formativo del estudiante de Medicina, lo que obstaculiza su desempeño profesional. Sobre la base del diagnóstico realizado, se confirma como fortaleza el interés por la búsqueda de información relacionada con la detección de secuelas discapacitantes pos-COVID-19.

Introduction: In the continuous training process of medical students, it is necessary to incorporate current issues; likewise, it is important to know the problems to seek solutions with the science support. Objective: To diagnose the training process of medical students as for the detection of incapacitating sequelae post-COVID-19. Methods: An observational, descriptive and cross-sectional study, with qualitative approach, of 20 students from 5th year of Medicine career, belonging to the University of Medical Sciences in Camagüey was carried out during their stay for the Public Health subject, from July to December, 2022. For such a purpose it was designed and applied an evaluative instrument with dimensions and indicators. Results: It was found that 50.0% of these students were in the age range of 21-26 years, while 65.0% were female. The cognitive dimension was evaluated as bad because 3 indicators, of the 4 that made it up, received that qualification; the same happened with the instrumental dimension. On the other hand, the attitudinal dimension and its 2 indicators were qualified as good. Conclusions: Inadequacies existed in the training process of medical students, which block their professional performance. On the base of the diagnosis, the interest in searching for information related to the detection of post-COVID-19 incapacitating sequelae is confirmed as strength.

Analysis of pulmonary function in post-Covid-19 patients at a university hospital / Análise da função pulmonar de pacientes com síndrome pós-covid-19 em um hospital universitário

Objective: Evaluate the spirometry pattern of patients who persisted with respiratory symptoms after infection with SARS-Cov-2. Methods: Cross-sectional, observational, retrospective study in a single center, approved by the local Ethics Committee (registration number: 5,120,720). Patients who underwent spirometry due to Post-Covid Syndrome were evaluated to analyze the spirometric pattern presented. The following were collected: exam identification data, sex, age, symptom time, the need for mechanical ventilation, and quality of spirometry, in addition to the following exam parameters: FVC, FEV1, FEV1/FVC, FEV 25-75/FVC, and FEV 75, evaluating the Lower Limit of Normality, pre-bronchodilator and post-bronchodilator values. Results: Data from 72 patients were collected. Of these, 55.5% of patients had spirometry results within normal limits. The most frequent respiratory alteration was obstructive respiratory disorder, present in 29.2% of the patients. Conclusions: The presence of dyspnea in patients with normal spirometry may indicate further evaluation of lung function and other etiologies for dyspnea (AU).

Objetivo: Avaliar o padrão de espirometria de pacientes que persistiram com sintomas respiratórios após a infecção pelo SARS-CoV-2. Métodos: Estudo transversal, observacional e retrospectivo realizado em um único centro, aprovado pelo Comitê de Ética local (número do parecer: 5.120.720). Foram avaliados pacientes submetidos a espirometria devido à Síndrome Pós-Covid, a fim de analisar o padrão espirométrico apresentado. Os seguintes dados foram coletados: identificação do exame, sexo, idade, tempo de sintomas, necessidade de ventilação mecânica, qualidade da espirometria, além dos seguintes parâmetros do exame: CVF, VEF1, VEF1/CVF, VEF 25-75/CVF e VEF 75, avaliando o Limite Inferior da Normalidade, valores pré-broncodilatador e pós-broncodilatador. Resultados: Foram coletados dados de 72 pacientes. Destes, 55,5% apresentaram resultados espirométricos dentro dos limites normais. A alteração respiratória mais frequente foi o distúrbio ventilatório obstrutivo, presente em 29,2% dos pa-cientes. Conclusões: A presença de dispneia em pacientes com espirometria dentro da normalidade pode indicar uma avaliação adicional da função pulmonar, assim como outras etiologias para a dispneia (AU).

Pleural empyema after COVID-19: A delayed presentation

Globally, the number of coronavirus disease-2019 (COVID-19) cases and deaths shows a declining trend since a peak in January 2022. For now, the pandemic phase looks to be ended, until a severe new variant may trigger another wave. At present, in India, small pockets of COVID-19 cases and post-COVID complications are still being reported. Therefore, physicians should remain vigilant about the atypical presentations and potential delayed or long-term complications of SARS-CoV-2 infection, even in individuals who had a mild COVID-19 infection. Here, we present the case of a 52-year-old male patient with a history of hypertension, who is a non-smoker and developed culture-negative pleural empyema 7 months after a mild COVID-19 infection. The patient was successfully treated with antibiotics and early video-assisted thoracoscopic surgery

Diarrea en pacientes con COVID-19 y en el síndrome pos-COVID

La COVID-19, actual pandemia global, es causada por el coronavirus SARS-CoV-2, capaz de provocar un síndrome respiratorio agudo grave. Esta enfermedad es multisistémica y heterogénea, y no siempre se relaciona con la gravedad de la enfermedad pulmonar. De hecho, hasta un tercio de los pacientes puede presentar síntomas gastrointestinales como la diarrea -que se ha reportado como uno de los de mayor impacto-, tanto a consecuencia de la infección aguda como del síndrome pos-COVID-19. Además, los diversos esquemas de tratamientos que se indican pueden tener efectos sobre la diarrea, lo que la convierte en un motivo frecuente de consulta en la especialidad de gastroenterología. Los pacientes con enfermedades intestinales previas podrían ser más susceptibles a esta manifestación. Debido a esto, se realizó una búsqueda exhaustiva de artículos sobre el tema, publicados en revistas científicas de alta visibilidad, cubanas y extranjeras, con el objetivo de exponer las causas y características de la diarrea que se presenta en pacientes infectados con SARS-CoV-2. Se recopilaron 168 artículos, de los cuales 30 fueron utilizados en la presente revisión, que permitirá documentar a los médicos de asistencia, para un mejor manejo de la diarrea en pacientes en las fases mencionadas.

COVID-19, the current global pandemic, is produced by the SARS-CoV-2 coronavirus, capable of causing a severe acute respiratory syndrome. This disease is multi-systemic and heterogeneous, and is not always related to the severity of the lung disease. In fact, up to a third of the patients can show gastrointestinal symptoms like diarrhea-which has been reported as one of the most impactful-both as a consequence of the acute infection and of the post-COVID-19 syndrome. In addition, the various treatment schemes indicated may have effects on diarrhea, what makes them a frequent reason for consultation in the specialty of gastroenterology. Patients with previous intestinal diseases could be more susceptible to this manifestation. Due to this, an exhaustive search of articles on the theme, published in Cuban and foreign journals of high visibility, was carried out, with the aim of exposing the causes and characteristics of the diarrhea that occurs in patients infected by SARS-CoV-2. 168 articles were compiled, of which 30 were used in the current review, which will allow documenting the attending physician for a better management of diarrhea in patients in the mentioned phases.

Aged people's health needs in the face of long covid-19 and access to health services / Requerimientos de salud de adultos mayores frente a covid-19 prolongado y acceso a servicios de salud / Necessidades de saúde dos idosos frente à covid longa e o acesso aos serviços de saúde

ABSTRACT Objective: to understand the health needs of aged people who had long Covid-19 and details about access to the health system to meet these demands. Method: an exploratory and qualitative study carried out with 41 aged individuals who had Covid-19 in 2020 and presented residual symptoms 18 months after the infection. Data collection took place between February and July 2022 through semi-structured interviews via telephone calls. In the analysis, initial and focused coding analytical techniques were used and the conceptual basis was grounded on the Primary Health Care "Accessibility" attribute. Results: four categories emerged when analyzing the results, namely: Understanding the need for professional care; Recognizing the demands that led aged people to seek health services; Understanding availability of the services; and Analyzing payment capacity. Conclusion: the aged population has developed specific health demands related to long Covid-19, and public and private health services are heterogeneous in their approach to this new condition, as care based on guidelines proposed by official bodies is not unanimous in public and private services and Health Plan Operators.

RESUMEN Objetivo: averiguar las necesidades de salud de los adultos mayores que tuvieron Covid-19 prolongado y detalles del acceso al sistema de salud para suplir estos requerimientos. Método: estudio cualitativo y exploratorio realizado con 41 adultos mayores que tuvieron Covid-19 en 2020 y presentaron síntomas residuales 18 meses después de la infección. La recolección de datos tuvo lugar entre febrero y julio de 2022 por medio de entrevistas telefónicas semiestructuradas; en el análisis se utilizaron las técnicas analíticas de codificación inicial y focalizada y la base conceptual se fundamentó en el atributo "Accesibilidad" de la Atención Primaria de la Salud. Resultados: surgieron cuatro categorías en el análisis de los resultados, a saber: Comprender la necesidad de atención profesional; Reconocer los requerimientos que llevaron a los adultos mayores a procurar un servicio de salud; Percibir la disponibilidad de los servicios; y Analizar la capacidad de pago. Conclusión: la población anciana desarrolló requerimientos de la salud específicos relacionados con Covid-19 prolongado y los servicios de salud públicos y privados presentan cierta heterogeneidad en relación al enfoque de esta nueva condición, puesto que la atención basada en directrices propuestas por órganos oficiales no es unánime en los servicios públicos, privados y de Operadoras de Planes de Salud.

RESUMO Objetivo: conhecer as necessidades de saúde dos idosos que tiveram a Covid longa e o acesso ao sistema de saúde para atender essas demandas. Método: estudo qualitativo exploratório, realizado com 41 idosos que tiveram Covid-19 no ano de 2020 e apresentaram sintomas residuais após 18 meses da infecção. A coleta de dados ocorreu entre fevereiro e julho de 2022 por meio de entrevistas semiestruturadas via telefone. Na análise foram utilizadas as técnicas de codificação inicial e focalizada e a base conceitual se fundamentou no atributo "Acessibilidade" da Atenção Primária à Saúde. Resultados: na análise dos resultados emergiram quatro categorias: Compreendendo a necessidade de atendimento profissional; Reconhecendo as demandas que levaram os idosos a buscar o serviço de saúde; Percebendo a disponibilidade dos serviços; e Analisando a capacidade de pagamento. Conclusão: a população idosa desenvolveu demandas específicas de saúde relacionadas à Covid longa, e os serviços de saúde público e privado possuem heterogeneidade quanto à abordagem dessa nova condição, uma vez que o atendimento pautado em diretrizes propostas por órgãos oficiais não é unânime nos serviços públicos, privados e Operadoras de Plano de Saúde.

Post-acute COVID-19 in three doses vaccinated autoimmune rheumatic diseases patients: frequency and pattern of this condition

Abstract Background Data on post-acute COVID-19 in autoimmune rheumatic diseases (ARD) are scarce, focusing on a single disease, with variable definitions of this condition and time of vaccination. The aim of this study was to evaluate the frequency and pattern of post-acute COVID-19 in vaccinated patients with ARD using established diagnosis criteria. Methods Retrospective evaluation of a prospective cohort of 108 ARD patients and 32 non-ARD controls, diagnosed with SARS-CoV-2 infection (RT-PCR/antigen test) after the third dose of the CoronaVac vaccine. Post-acute COVID-19 (≥ 4 weeks and > 12 weeks of SARS-CoV-2 symptoms) were registered according to the established international criteria. Results ARD patients and non-ARD controls, balanced for age and sex, had high and comparable frequencies of ≥ 4 weeks post-acute COVID-19 (58.3% vs. 53.1%, p = 0.6854) and > 12 weeks post-acute COVID-19 (39.8% vs. 46.9%, p = 0.5419). Regarding ≥ 4 weeks post-acute COVID-19, frequencies of ≥ 3 symptoms were similar in ARD and non-ARD controls (54% vs. 41.2%, p = 0.7886), and this was also similar in > 12 weeks post-acute COVID-19 (68.3% vs. 88.2%, p = 0.1322). Further analysis of the risk factors for ≥ 4 weeks post-acute COVID-19 in ARD patients revealed that age, sex, clinical severity of COVID-19, reinfection, and autoimmune diseases were not associated with this condition (p > 0.05). The clinical manifestations of post-acute COVID-19 were similar in both groups (p > 0.05), with fatigue and memory loss being the most frequent manifestations. Conclusion We provide novel data demonstrating that immune/inflammatory ARD disturbances after third dose vaccination do not seem to be a major determinant of post-acute COVID-19 since its pattern is very similar to that of the general population. Clinical Trials platform (NCT04754698).

Impacto de la pandemia por COVID-19 en persona sana y físicamente activa. Reporte de un caso y actualización de los principales hallazgos / Impact of the COVID-19 pandemic on a healthy and physically active person. Case report and update of the main findings

Introducción. No todas las personas expuestas al COVID-19 desarrollan una en-fermedad respiratoria grave y el número de personas adultas jóvenes sin patologías previas, afectadas gravemente por el virus, viene en aumento. Se ha evidenciado un gran número de síntomas inespecíficos y complicaciones, posterior a la recuperación. Objetivo. Evaluar las repercusiones en un sujeto sano y físicamente activo que pre-sentó complicaciones médicas graves y complicaciones posteriores al COVID-19. Reporte de caso. Hombre de 41 años de edad, físicamente activo y sin enfermeda-des conocidas, en quien se documenta infección por SARS-CoV2 con prueba PCR positiva. Requirió 22 días en UCI, 17 días en hospitalización general, 57 días de incapacidad y posterior a doce meses presenta pérdida evidente de peso y de memo-ria, dificultad para pensar y concentrarse, pérdida de masa muscular, compromiso de la función hepática, cansancio y fatiga, dolor muscular, problemas para dormir, cambios en el estado de ánimo y alteraciones del gusto. De acuerdo con los actuales hallazgos, la producción de un tipo de anticuerpo impide que el sistema inmune ten-ga una respuesta adecuada contra la enfermedad. Sumado a esto, se ha descrito una nueva puerta de entrada del virus en el organismo: la proteína neuropilina-1 (NRP1), además de la posible disminución del surfactante que permite la flexibilidad de los pulmones. Lo anterior podría dar respuestas a las complicaciones en personas sanas y físicamente activas posterior a la infección por COVID-19. Conclusiones. Entendiendo que el COVID-19 es una enfermedad reciente, aún hay mucha información por recolectar para así entender su comportamiento en el cuerpo humano. Sin embargo, las investigaciones van dando evidencia del porqué el COVID-19 puede generar graves complicaciones médicas en personas sanas y físicamente activas. Son necesarias más investigaciones con esta población, para así realizar planteamientos de manejo clínico acordes a la enfermedad y evitar desenlaces fatales.

Introduction. Not all people exposed to COVID-19 develop a severe respiratory disease and the number of young adults without previous pathologies, seriously af-fected by the virus, is increasing. Many of non-specific symptoms and complications have been evidenced after the recovery. Objective. To evaluate the repercussions in a healthy and physically active subject who presented serious medical complications and post-COVID-19 complications.Case report. A 41-year-old man, physically active and without known diseases, in whom SARS-CoV2 infection with a positive PCR test is documented. He required 22 days in the ICU, 17 days in general hospitalization, 57 days of disability and after twelve months there is evident weight and memory loss, difficulty thinking and con-centrating, loss of muscle mass, compromised liver function, tiredness and fatigue, muscle pain, sleep problems, changes in mood, and alterations in the taste. According to the current findings, the production of a type of antibody prevents the immune system from having an adequate response against the disease. In addition to this, a new gateway for the virus into the body has been described: the protein neuropilin- 1 (NRP1), as well as the possible decrease in surfactant that allows the flexibility of the lungs. This could provide answers to complications in healthy and physically active people after COVID-19 infection. Conclusions. Understanding that COVID-19 is a recent disease, there is still a lot of information to collect to understand its behavior in the human body. However, research is providing evidence on why COVID-19 can cause serious medical compli-cations in healthy and physically active people. Understanding that it is a multifac-torial situation, more research is necessary with this population in order to carry out clinical management approaches according to the disease and avoid fatal outcomes.

Síndrome pos-COVID-19: solo sabemos que sabemos poco / Pos-COVID-19 syndrome: we only know how little we know

La COVID-19 puede producir síntomas persistentes luego de la infección inicial. En cuadros más graves, pueden corresponder a la evolución propia de una patología crítica o a secuelas inflamatorias/fibróticas pulmonares, entre otras. Esto puede confirmarse por estudios respiratorios e imagenológicos. En el caso de la COVID-19 no grave, el denominado síndrome pos-COVID-19, se trata de síntomas persistentes luego de al menos 28 días sin una secuela orgánica clara. Los síntomas más comunes en este caso son fatiga, cefalea y disnea, que pueden persistir meses luego de la infección inicial. Su curso puede ser oscilante e incluso aumentar progresivamente. El espectro de síntomas es muy amplio y requiere una adecuada evaluación del paciente. Se cree que tiene su origen en la desregulación inmunológica luego de la infección inicial. Su evaluación y seguimiento requieren un adecuado manejo sintomático y acompañamiento por el profesional a cargo. (AU)

Patients who underwent COVID-19 can develop persisting symptoms and sequelae. Severe cases may exhibit systemic complications of critical care and/or inflammatory/fibrotic lung injury. Imaging and respiratory function tests can assist in the evaluation of both. Nonsevere cases can also develop persisting symptoms for more than 28 days, which has been defined as the post COVID-19 syndrome. The most common symptoms in said syndrome are fatigue, headache and dyspnea, which can last for months. Its course can be oscillating or even increase progressively within the first months. The considerable range of symptoms requires proper patient assessment. Post-infectious immune disregulation is believed to be the source of this syndrome. Proper assessment and followup warrant measured symptom management and emphatic care by the attending physician. (AU)

Clinical characteristics of a group of patients who persist with respiratory symptoms after the acute phase of COVID-19

Abstract In convalescence from the SARS-CoV-2 infection, a high number of patients require medical consultation due to persisting symptoms. Objective: To describe the clinical characteristics of patients who attend the Department of Respiratory Medicine due to persisting respiratory or thoracic symptoms after COVID-19 epidemiological discharge, and to assess their etiology by applying a follow-up protocol. Materials and Methods: we included patients previously diagnosed with COVID-19 through PCR or with a combination of symp toms and epidemiological criteria who attended the Department of Respiratory Medicine spontaneously or referred by another health professional. Clinical examination, chest X-ray, spirometry, laboratory analysis, and the EQ-5D quality of life and PHQ-9 depression questionnaires were performed. According to the findings, the evaluation was complemented with D-dimer, six-minute walk test (6MWT), computed tomography (CT) and cardiac evaluation, following a predetermined algorithm. Mental health consultation was offered to patients with a result ≥ 10 in the PHQ-9 questionnaire. Results: 95 patients were included: age 48 ± 11 years, BMI (Body Mass Index) = 28.4 ± 4.9 kg/m2, 57 (60%) women and 64 (67.5%) Argentinians. Among foreigners: 19 (20%) were Bolivian, 8 (8.5%) Peruvian and 4 (4%) Paraguayan. 91 patients had a PCR-confirmed diagnosis; and from the remaining patients, two had positive serology and two clinical and epidemiological criteria. The most frequent comorbidities were: smoking (34%), arterial hypertension (21%), diabetes (16%), asthma (11%) and tuberculosis (5%); 38% did not refer any. 45 patients had been hospitalized, and 8 of them required treatment in the intensive care unit (ICU). The consultation time from epidemiological discharge was 46 ± 34 days (median = 38 days), and the most frequent symptoms were dyspnea (60%), cough (32%), chest pain (26%), low back pain (22%) and asthenia (10.5%); 50 patients required non-steroidal anti-inflammatory drugs (NSAIDs) for pain management. Regarding the depression questionnaire: 79% presented PHQ-9 > 4 (mild depression) and 36% ≥ 10 (moderate and severe depression); in the latter group we found higher prevalence in women: 44 vs. 24%, p= 0.03. We didn't find a relationship between depression assessed with PHQ-9 and age, nationality or isolation location; 13 patients agreed to consult with the Department of Mental Health (PHQ-9 14.9 ± 4; EQ-5D 39 ± 10). In 6 patients, the spirometry showed values of forced expiratory volume in the first second (FEV1) and/or forced vital capacity (FVC) < 80%; they had history of pneumoconiosis (n = 1), asthma (n = 1) and obesity (n = 1), two presented an abnormal chest X-ray and the other one had been treated in the intensive care unit (ICU). Additional studies were performed in 24 patients (six-minute walk test [6MWT]: 3, CT: 6, echocardiogram: 2, D-dimer: 21). Persistence of ground-glass densities was found in 5 of the 6 tomographies. None of the patients required an additional medical approach during follow-up. Conclusion: In post-COVID-19 patients, the most frequent symptoms for consultation were dyspnea, cough and chest or lumbar pain, as well as the finding of depression assessed by a questionnaire. The results favor the holistic approach in the evaluation and follow-up of these cases.

Long term effect of acute COVID-19 / Монголын Анагаах Ухаан

@#Most of the infected patients completely recovered after covid-19 infection. However, a substantial proportion of patients who have been infected with SARS-CoV-2 continue to have symptoms long past the time that they recovered from the initial phases of covid-19 disease. At NICE guideline, </br> 1. Acute covid-19: signs and symptoms of covid-19 for up to 4 weeks, </br> 2. Ongoing symptomatic covid-19: signs and symptoms of covid-19 from 4 to 12 weeks, </br> 3. Post-covid-19 syndrome: signs and symptoms that develop during or after an infection consistent with covid-19, continue for more than 12 weeks and are not explained by an alternative diagnosis. </br> In addition to the clinical case definitions, ‘long covid’ is commonly used to describe signs and symptoms that continue or develop after acute covid-19. As the pandemic of covid-19 continues, numerous additional symptoms, such as fever, dry cough, shortness of breath, fatigue, myalgias, vomiting or diarrhea, headache and weakness. Other critical and severe complications of covid-19 can include impaired function of the heart, brain, lung, liver, kidney, and coagulation system. Early reports have now emerged on post-acute infectious consequences of covid-19, with studies from the United States, Europe and China reporting outcomes for those who survived hospitalization for acute covid-19. An observational cohort study from 38 hospitals in Michigan, United States evaluated the outcomes of 1,250 patients discharged alive at 60 day. Of 488 patients who completed the telephone survey in this study, 32.6% of patients reported persistent symptoms. Dyspnea while walking up the stairs 22.9% was most commonly reported, while other symptoms included cough 15.4% and persistent loss of taste/smell 13.1%. Post-hospital discharge care of COVID-19 survivors has been recognized as a major research priority by professional organizations.

Recurrent headache as a post-COVID-19 sequela: A case report

@#Post-COVID condition is the presence of new, recurring, or ongoing signs and symptoms for greater than four weeks after a SARS-CoV-2 infection. Persistent headache as a neurologic sequalae of COVID-19 infection is a common prolonged symptom with limited characterization in the literature. This was a case of a 27-year-old female diagnosed with mild COVID-19 who presented with fever, colds, fatigue, headache, decreased hearing, sore throat, dry cough, pleuritic chest pain, anosmia, ageusia, myalgia, and severe low back pain. Headache was described as remitting, frontally located, squeezing and moderate to severe in pain intensity. She was admitted in a tertiary COVID referral hospital for 8 days and was managed supportively. On the 10th day of illness, symptoms had resolved except for an on and off headache. The residual recurrent headache lasted for more than 5 months after being tested negative for SARSCOV2 on repeat reverse transcriptase-polymerase chain reaction (RT-PCR). The possible pathophysiologic mechanisms for neurologic manifestations and prolonged headache were hypoxia, endothelial damage through angiotensin converting enzyme receptor, and cytokine reactions. The characteristics of the symptoms remained unclear despite the proposed mechanisms for prolonged headache among COVID-19 patients.