ABSTRACT
Background Traumatic brain injury (TBI) is a common cause of death and disability, worldwide. Early recognition of patients with brain cellular damage allows for early rehabilitation and patient outcome improvement. Serum protein S-100B determinations have been widely suggested the most promising biomarker for TBI. It has been proposed that this marker is useful in a Neurointensive Care Unit (NICU) as a monitoring parameter. The main objective of this study is to assess the value of including acute S100B levels in standard clinical data as an early screening tool for brain death after severe TBI. Material and methods In this prospective study, the clinical conditions of patients with mild to moderate TBI were assessed and patient serum S100B levels measured within 24h of injury were eligible for inclusion in the study using by electro chemi luminescence (ECL). Patients were admitted to The Govt. Trauma Centre, P.B.M. Hospital, Bikaner in NICU and followed up one month later and evaluated for level of consciousness, presence or absence of post-traumatic headache, and daily activity performance (using the Barthel scale). Student's t-test and the chi-square test were used for the data analysis, which was performed using SPSS software. Result and discussion The mean serum S100B value was significantly lower for patients with minor TBI than for patients with moderate TBI (20.4 ± 12.6 ng/dl and 124.0 ± 235.0 ng/dl, respectively). Patients with normal CT scans also had statistically significantly lower serum S100B levels than patients with abnormal CT findings. The mean S100B value was statistically significantly higher for patients with suspected diffused axonal injury (596.18 ± 502.1 ng/dl) than for patients with other abnormal CT findings (p=0.000): 20.97 ± 19.9 ng/dl in patients with normal CT results; 39.56 ± 21.7 ng/dl in patients with skull bone fracture; 50.38 ± 22.9 ng/dl in patients with intracranial haemorrhage; and 70.23 ± 31.3 ng/dl in patients with fracture plus intracranial haemorrhage. Conclusion Serum S100B levels increase in patients with minor to moderate TBIs, especially in those with diffused axonal injury. However, serum S100B values cannot accurately predict one-month neuropsychological outcomes and performance.
ABSTRACT
ABSTRACT. Post-traumatic headache (PTH) is the most common symptom found in the post-traumatic syndrome, whose onset occurs within seven days of the trauma. The condition is characterized as acute when it persists for up to 3 months. PTH beyond this period is considered chronic. Objectives: The objective of this study was to determine the clinical features of chronic post-traumatic headache (cPTH) and its association with depression, anxiety and quality of life. Methods: A total of 73 female subjects were evaluated. Patients were divided into three groups: (a) group without headache, CONTROL, n=25; (b) cPTH group, n=19; and (c) MIGRAINE, n=29, with all subjects in the 11-84 year age group. Symptoms of anxiety and depression were evaluated by the Beck inventories of anxiety and depression, and quality of life assessed by the Lipp and Rocha quality of life inventory. Qualitative variables were analyzed using the Chi-square or Fisher's exact tests and expressed as percentages whereas quantitative variables were analyzed by ANOVA, Mann-Whitney or Kruskal-Wallis tests with data expressed as mean±standard deviation, p<0.05. Results: Subjects with cPTH presented with headache manifesting similar features to those found in migraine. The cPTH group was associated with similar levels of anxiety and depression to the migraine group and higher than the CONTROL (p<0.001). Quality of life of individuals with cPTH was similar to that of subjects with migraine and lower than CONTROL subjects (p<0.05). Conclusions: cPTH presents similar clinical characteristics to migraine. Subjects with cPTH had high levels of anxiety and depression symptoms and reduced quality of life.
RESUMO. A cefaleia é o sintoma mais encontrado na síndrome pós-traumática, iniciando-se dentro de sete dias após o trauma. Sua a forma aguda dura até três meses e a crônica persiste após este período. Objetivos: O objetivo deste estudo foi determinar as características clínicas da cefaleia pós-traumática crônica (CPTc) e sua associação com a depressão, ansiedade e com nível de qualidade de vida. Métodos: Foram avaliados 73 sujeitos do gênero feminino, divididos em três grupos: (a) grupo sem cefaleia (CONTROLE, n=25), (b) grupo com CPTc (n=19) e (c) migrânea (MIGRÂNEA, n=29), com idades variando entre 11 e 84 anos. Os sintomas de ansiedade e depressão foram avaliados pelos inventários de ansiedade e depressão de Beck e a qualidade de vida pelo inventário de qualidade de vida de Lipp e Rocha. As variáveis qualitativas foram analisadas pelos testes qui-quadrado ou exato de Fisher e expressas em percentuais e as quantitativas por ANOVA, Mann-Whitney ou Kruskal-Wallis com os dados apresentados em média±desvio padrão, p<0,05. Resultados: Os sujeitos com CPTc apresentaram cefaleia com características semelhantes as encontradas na migrânea. A CPTc esteve associada aos níveis de sintomas de ansiedade e depressão similares ao grupo com migrânea e superior ao CONTROLE (p<0,001). Os níveis de qualidade de vida dos sujeitos com CPTc mostraram-se semelhantes aos dos sujeitos com migrânea e inferior ao CONTROLE (p<0,05). Conclusões: A CPTc apresenta características clínicas semelhantes a migrânea. Os sujeitos com CPTc apresentam elevado nível de sintomas de ansiedade e depressão e nível de qualidade de vida reduzida.
Subject(s)
Humans , Anxiety , Depression , Post-Traumatic Headache , HeadacheABSTRACT
JUSTIFICATIVA E OBJETIVOS: De acordo com a Classificação Internacional das Cefaleias, a cefaleia pós-traumática é caracterizada por dor de intensidade variável, máxima na área do trauma, que se inicia em até sete dias após a lesão. O objetivo deste estudo foi relatar o caso de cefaleia pós-traumática crônica, secundária à lesão por arma de fogo. A dor era desencadeada pela palpação de pontos de gatilho em cicatriz.RELATO DO CASO: Paciente do sexo masculino, 31anos, sofreu lesão por arma de fogo na região cervical esquerda,desenvolvendo cefaleia refratária, com área máxima em região de cicatriz. Observou-se ponto de gatilho nessa região. Foi proposto tratamento com bloqueio periférico com excelente resposta.CONCLUSÃO: Sugere-se que a formação de neuromas em áreas de cicatriz possa estar envolvida com a fisiopatologia da cefaleia pós-traumática.
BACKGROUND AND OBJECTIVES: According to the International Classification of Headache Disorders,post-traumatic headache is characterized by pain of variable intensity, maximum in the trauma area, which starts up to seven days after the injury. This study aimed at reporting a case of post-traumatic chronic headache, secondary to firearm injury. Pain was triggered by palpation of triggering points at the scar.CASE REPORT: Male patient, 31 years old, suffered afirearm injury at the left cervical region, developing refractory headache with maximum area at the scar region.Triggering points at the scar region were observed. A treatment with peripheral block was proposed with excellent response.CONCLUSION: It is suggested that the formation of neuromas in scar areas may be involved with the pathophysiology of post-traumatic headache.
Subject(s)
Male , Neuroma , Post-Traumatic HeadacheABSTRACT
BACKGROUND: Greater occipital nerve block is used in the treatment of headaches and neuralgia in the occipital area. We evaluated the efficacy of ultrasonic doppler flowmeter-guided occipital nerve block in patients experiencing headache in the occipital region in a randomized, prospective, placebo-controlled study. METHODS: Twenty-six patients, aged 18 to 70, with headache in the occipital region, were included in the study. Patients received a greater occipital nerve block performed either under ultrasonic doppler flowmeter guidance using 1% lidocaine or the traditional method. Sensory examination findings in the occipital region were evaluated. RESULTS: The complete block rate of greater occipital nerve blockade in the doppler group was significantly higher than in the control group respectively (76.9% vs. 30.8%, P < 0.05). Only one patient in the control group had a complication (minimal bleeding). CONCLUSIONS: Ultrasonic doppler flowmeter-guided occipital nerve block may be a useful method for patients suffering headache in the occipital region.
Subject(s)
Aged , Humans , Flowmeters , Headache , Lidocaine , Migraine Disorders , Nerve Block , Neuralgia , Post-Traumatic Headache , Prospective Studies , Stress, Psychological , Ultrasonics , Ultrasonography, DopplerABSTRACT
The onset of post-traumatic headache (PTC) occurs in the first seven days after trauma, according to the International Headache Society (IHS) classification. The objective of this study was to evaluate the several forms of headache that appear after mild head injury (HI) and time interval between the HI and the onset of pain. We evaluated 41 patients with diagnosis of mild HI following the IHS criteria. Migraine without aura and the chronic tension-type headache were the most prevalent groups, occurring in 16 (39 percent) and 14 (34.1 percent) patients respectively. The time interval between HI and the onset of headache was less than seven days in 20 patients (48.7 percent) and longer than 30 days in 10 (24.3 percent) patients. The results suggest that PTC may arise after a period longer than is accepted at the present by the IHS.
O início da cefaléia pós-traumática (CPT) ocorre dentro de sete dias após o trauma, de acordo com a classificação da Sociedade Internacional de Cefaléia (SIC). O objetivo deste estudo foi avaliar as diversas formas de cefaléia que surgem após o traumatismo cranioencefálico (TCE) leve e o intervalo de tempo entre o TCE e o início da dor. Foram avaliados 41 pacientes com diagnóstico de cefaléia pós-traumática leve segundo os critérios da SIC. Migrânea sem aura e cefaléia do tipo tensional crônica foram os tipos de cefaléia mais comuns, ocorrendo em 16 (39 por cento) e 14 (34,1 por cento) dos pacientes respectivamente. O intervalo de tempo entre o TCE e o início da cefaléia foi menor que sete dias em 20 pacientes (48 por cento) e maior que 30 dias em 10 (24,3 por cento) pacientes. Estes resultados sugerem que a CPT pode surgir após período maior do que é aceito atualmente pela SIC.