ABSTRACT
Lung cancer is one kind of malignant tumors with the highest morbidity and mortality, and lung cancer metastasis is the leading cause of death in patients. Lung cancer metastasis is a complex process. A large number of studies have confirmed that lung tumors can secrete soluble molecules, mobilize and recruit related bone marrow cells or immune cells, regulate the matrix remodeling in distant organs which leads to the formation of pre-metastatic niche, therefore, promote tumor cells metastasis and implantation in distant organs. Detection of key target factor molecules and cellular components involving in pre-metastatic niche is of great clinical significance for diagnosis and prognostic evaluation. This article will summarize the progression of lung cancer metastasis modulated by the pre-metastatic niches and its clinical application status.