ABSTRACT
The outcome of this review is to assess the association between pre-pregnancy obesity and PPCM incidence. There were a total of 5.373.581 participants were included in this study. Pre-pregnancy obesity was significantly associated with PPCM incidence compared to normal-weight subjects (OR ¼ 1.79 (1.16,2.76); p ¼ 0.008; I 2 ¼ 59%, Pheterogeneity ¼ 0.04). The sub-group analysis showed that pre-pregnancy women with obesity class I (OR ¼ 1.58 (1.20,2.07); p ¼ 0.001; I 2 ¼ 0%, Pheterogeneity ¼ 0.64) and class II and III (OR ¼ 2.65 (2.04,3.45); p < 0.001; I 2 ¼ 6%, Pheterogeneity ¼ 0.36) was significantly associated with PPCM incidence compared to normal-weight subjects.
ABSTRACT
The prevalence of obesity among pregnant women is increasing,that include pre-pregnancy obesity and/or over gestational weight gain diagnosed by different criteria in different countries.Emerging evidance suggests that maternal obesity before and during pregnancy have not only short-term effects on both of mother and offspring,but also long-term adverse influences on offspring health.Evidence from both animal and human studies indicates that maternal obesity increases the weight and adiposity,alters body composition and increases the risk of metabolic disorders.These changes further result in the increased risk of metabolic syndrome of offspring in their later life.Further studies are required to elucidate the programming mechanisms of disease risk in the offspring as a consequence of matemal obesity.Strategies to prevent and reduce the impact of maternal obesity on long-term health of offsprings are required.