ABSTRACT
Objective To investigate the reference interval of neonatal nutrition assessment biochemical factor,including total protein (TP),serum albumin (ALB),serum prealbumin (PA) and serum retinol binding protein (RBP).Methods From December 2016 to August 2017,403 serum specimens were collected from health neonates in Hunan Children's Hospital and the serum concentration of TP,ALB,RBP and PA was detected.The results of each item were grouped according to sex and age,and then the reference interval of each item was established.Results When data was separated by gender of each item,there was no statistical significance between each group of each item (P ＞ 0.05).For the TP,ALB and RBP,separating the data of each item by weeks,there were also no statistical significance between each group (P ＞ 0.05).But there was statistical difference between one week old group and the rest groups in the data of PA (P ＜ 0.05).The normal reference interval of neonatal serum total protein,albumin,retinol binding protein and pre-albumin are as follow:(40.69-65.72) g/L,(28.77-42.3) g/L,(12.13-33.19) mg/L,(42.26-161.52) mg/L (no more than 7 days old) and (59.05-170.23) mg/L (range from 8 to 28 days old).Conclusions We can establish the reference interval of TP,ALB and RBP without differentiating gender and weeks.But for the PA,the reference interval of one-week-old neonate needs to differentiate from other neonates.
ABSTRACT
Objective To explore the clinical application value of the prealbumin (PA),total bile acid (TBA),and red blood cell volume distribution width (RDW) in chronic liver disease.Methods Totally 393 cases of patients with chronic liver disease admitted by Xiangya Hospital of Central South University from March 2015 to March 2016 were selected as group observation,and were divided into chronic hepatitis,compensated liver cirrhosis,decompensated liver cirrhosis and primary liver cancer.At the same time,200 cases of healthy volunteers were collected as normal control.Serum prealbumin and total bile acids were tested as well as the RDW of all cases.SPSS 17.0 software was used for data statistics processing.The receiver-operating characteristic curve (ROC) was drawn to evaluate the diagnosis value of the indexes in chronic liver disease severity.Results PA in the observation group was significantly lower than normal control,while its TBA and RDW were significantly higher than normal control.All of three parameters in patients,especially with liver cirrhosis and decompensated liver cirrhosis,had higher positive rate.When the clinical diagnosis was taken as gold standard,the best level of PA to diagnose primary liver cancer,chronic hepatitis and decornpensated liver cirrhosis was 244.7 mg/L,238.5 mg/L and 132.8 mg/L,the AUC was 0.973,0.909 and 0.879,the sensitivity was 92.3％,95.1％ and 85.6％,and the specificity was 95.8％,72.8％ and 79.7％;the best level of RDW to diagnose primary liver cancer,chronic hepatitis and decompensated liver cirrhosis was 13.2％,13.8％ and 14.3％,the AUC was 0.816,0.827 and 0.818,the sensitivity was 66.7％,77.4％ and 72.2％,and the specificity was 79.5％,73.8％ and 77.3％.When combined detection of PA and RDW,the diagnostic performance had improved significantly.Conclusions Serum prealbumin and total bile acid,as well as the whole blood RDW may objectively reflect the injury of liver metabolism and synthesis function,and for the early diagnosis and prognosis of patients with chronic liver disease has a important clinical significance.