ABSTRACT
Precious Tibetan medicine formula is a characteristic type of medicine commonly used in the clinical treatment of central nervous system diseases. Through the summary of modern research on the precious Tibetan medicine formulas such as Ratnasampil, Ershiwuwei Zhenzhu Pills, Ershiwewei Shanhu Pills, and Ruyi Zhenbao Pills, it is found that they have obvious advantages in the treatment of stroke, Alzheimer's disease, epilepsy, angioneurotic headache, and vascular dementia. Modern pharmacological studies have shown that the mechanisms of precious Tibetan medicine formulas in improving central nervous system diseases are that they promote microcirculation of brain tissue, regulate the permeability of the blood-brain barrier, alleviate inflammation, relieve oxidative stress damage, and inhibit nerve cell apoptosis. This review summarizes the clinical and pharmacological studies on precious Tibetan medicine formulas in prevention and treatment of central nervous system diseases, aiming to provide a reference for future in-depth research and innovative discovery of Tibetan medicine against central nervous diseases.
Subject(s)
Humans , Blood-Brain Barrier , Brain , Central Nervous System Diseases , Medicine, Tibetan Traditional , Stroke/drug therapyABSTRACT
To explore the pharmacogenomic markers that affect the platinum-based chemotherapy response in non-small-cell lung carcinoma (NSCLC), we performed a two-cohort of genome-wide association studies (GWAS), including 34 for WES-based and 433 for microarray-based analyses, as well as two independent validation cohorts. After integrating the results of two studies, the genetic variations related to the platinum-based chemotherapy response were further determined by fine-mapping in 838 samples, and their potential functional impact were investigated by eQTL analysis and in vitro cell experiments. We found that a total of 68 variations were significant at P < 1 × 10-3 in cohort 1 discovery stage, of which 3 SNPs were verified in 262 independent samples. A total of 541 SNPs were significant at P < 1 × 10-4 in cohort 2 discovery stage, of which 8 SNPs were verified in 347 independent samples. Comparing the validated SNPs in two GWAS, ADCY1 gene was verified in both independent studies. The results of fine-mapping showed that the G allele carriers of ADCY1 rs2280496 and C allele carriers of rs189178649 were more likely to be resistant to platinum-based chemotherapy. In conclusion, our study found that rs2280496 and rs189178649 in ADCY1 gene were associated the sensitivity of platinum-based chemotherapy in NSCLC patients.
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Background@#The medical works written by Darmo Maaramba Luvsanchoidog have been an important source for the theory, treatment, training and research of traditional Mongolian medicine. In recent years, number of his medical books written by dbu med (in English headless scriptures) have been found, but they are difficult to read or translate and have not been studied at all in Mongolia. Therefore, the study has been carried out to facilitate the use of handwriting medical scriptures by Darmo Maaramba Luvsanchoidog for research, teaching, and to explain complex words in his books.@*Purpose@#Explain the difficult words related to precious medicines in the book called “legs bshad be ed’u dkar poi ‘phreng ba zhes bya ba bzhugs so” written by Darmo Maaramba Luvsanchoidog.@*Research methods@#Methods of textual analysis for ancient books and analysis and synthesis were used in the study.@*Conclusion@#In the book “legs bshad be ed’u dkar poi ‘phreng ba zhes bya ba bzhugs so” written by Darmo Maaramba Luvsanchoidog clearly outlines the method of analyzing the sources of many precious medicines. Furthermore, the research identified that “legs bshad be ed’u dkar poi ‘phreng ba zhes bya ba bzhugs so” is a significant work to understand precious medicines in the main scriptures of medicine and thoroughly explained their content and terminology. In particular, ring srel (in English relic), which has long been forgotten in traditional medicine, has gained practical significance as it clearly explains its classification, nature, and use.
ABSTRACT
Chile es un país mundialmente conocido por su elevada producción de cobre. También reviste especial importancia el aporte de ingresos que realiza al Estado provenientes de las exportaciones. A partir del año 2003, se inicia el "super ciclo del cobre" como resultado del significativo aumento del precio a nivel internacional. Esta tendencia impactó positivamente en diversos sectores de la sociedad: académicos, empresarios y gobernantes; al punto de impulsar nuevos proyectos y millonarias inversiones. En este periodo, los mayores traspasos al fisco permitieron no solo ahorrar parte de los ingresos fiscales, sino que también financiar gastos estatales y varias reformas sociales comprometidas por los gobiernos de la época. A partir de 2013, se inicia una caída de los precios, incluso dramáticamente en los años siguientes, arrastrando a la industria a una compleja crisis. En los últimos quince años la productividad ha caído permanentemente y la producción se ha visto estancada, cuyo trasfondo son la reducción sostenida de las leyes del mineral y el alza de los costos de producción. Esta severa crisis "económica" que enfrenta el ciclo de explotación capitalista del cobre está en contradicción con la degradación indiscriminada e irreversible del ciclo de vida del metal y los recursos naturales. Esta situación, más el fracaso de la reforma tributaria, ha tenido serias repercusiones para las cuentas fiscales.
Chile is known worldwide for its high copper production. The export income that it generates for the state is also especially important. In 2003, the copper super cycle was unleashed as a result of the significant jump in copper prices. This trend had a positive impact on various sectors of society - academics, businessmen and government - sparking new projects and millions in investments. In this period, large transfers to the treasury not only permitted saving part of this tax revenue, but also financed state expenditures and various social reforms undertaken by governments during this time. In 2013, prices started dropping, even dramatically in the following years, dragging the industry into a complicated crisis. In the last 15 years, productivity has permanently fallen and production has been stagnant, set against the sustained decrease in ore grades and rising production costs. This severe "economic" crisis facing the capitalist copper mining cycle is in contradiction with the indiscriminate and irreversible degradation of the life cycle of metal and natural resources. This situation, combined with the failure of the tax reform, has had serious consequences on tax revenues.
Subject(s)
Economics , Chile , Materials ScienceABSTRACT
Objective:To investigate the effects of the treatment of early cracked teeth with vital pulp preservation.Methods:63 early cracked teeth with vital pulp in 56 patients were treated by light cured composite resin filling with or without MTA rebasing,and restored by precious metal crown.The patients were followed up for 2 years.Results:After 2 years follow-up,57 teeth were successfully treated and failure was found in 6 teeth,the effective rate was 90.4％.Conclusion:Light cured resin filling directly or with MTA rebasing for early cracked teeth with vital pulp,and restoration by precious metal crown are effective in the treatment of early cracked teeth with vital pulp.
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Este artigo foi escrito a partir da biografia Desejos secretos, a história de Sidonie C., a paciente homossexual de Freud (Rieder & Voigt, 2008) e do arranjo colocado em cena pelo Amor Cortês (Capelão, 2000) e pelo movimento As Preciosas. Nossa discussão está norteada por uma particular posição do sujeito em relação ao amor: quando o amor se sustenta somente mediante a segurança de um impedimento, de uma distância que prive e preserve, ao menos em parte, o sujeito do contato com seu amado. A necessidade de um amor inacessível, que visa precisamente à não realização, parece revelar que há algo insuportável em se deixar tomar em um enlace que consiga acolher alguma coisa de real, que implique transitar pelo desejo do Outro e que requeira alguma mudança de posição.
This article has been written from the biography Desejos secretos, a história de Sidonie C., a paciente homossexual de Freud (Rieder & Voigt, 2008) and from the arran gement brought to light by Courtly Love (Capelão, 2000) and by The Precious movement. Our discussion is guided by a particular subject's position in relation to love, when love is sustained only by the security of a constraint, a distance that deprives and preserves, at least in parts, the subject, from contacting the loved one. The need for an unattainable love, which specifically aims its non-achievement, seems to reveal that there is something unbearable in letting oneself engage into a bond which shelters something real, involves transiting through the desire of the Other and which requires some change of position.
Subject(s)
Humans , Sexual Abstinence/psychology , Love , Emotions , Homosexuality/psychology , PsychoanalysisABSTRACT
Heavy metal pollution has become one of the most serious environmental problems today. Biosorption, regarded as a cost-effective biotechnology for treating heavy metal of low concentration in wastewater, has not been utilized at large scale successfully. It’s helpful to increase the knowledge of biosorption mechanism and decreasing the costs of biosorbents for the biosorption application. The yeast of Saccharomyces cerevisiae is an ideal biomaterial to be used for exploring the mechanism and for actual utilization because of its unique characteristics in spite of its relatively mediocre capacity of metal uptake to other fungi. The yeast can grow easily in cheap media, and is widely used in food and beverage manufacture. It’s also a safe by-product in large quantity as a waste of the fermentation industry, and easily manipulated at molecular level. The metal uptake specifically by S. cerevisiae was addressed. Firstly, it was discussed to use dead or live cells in biosorption . The yeast can absorb toxic heavy metals (Pb, Hg, Cd, etc), precious metals (Au, Ag, Pd, etc) and radionuclides (U, Am, etc). Secondry, metal-binding capacity of various heavy metals by S. cerevisiae in different conditions were compared. Lead and uranium, for instances, can be effectively removed from dilute solutions, while copper is not easily removed. Thirdly, various mechanism of metal uptake by S. cerevisiae were summarized in details according to the position in which metals are located. Metal uptake process is influenced by the ratio of the initial concentration of metal ions and the concentration of biomass. Cellular wall and its components are important for metal uptake. Functional groups for metallic ion fixation have been identified. Uptake is typically accompanied by ion exchange and complexation, sometimes with precipitation (for Pb) and redox (for Au or Ag). Intracellularly accumulated metal is associated with the cell membrane, vacuole and GSH, but may also be bound to other cellular organelles and biomolecules. The equilibrium and kinetic models used in the metal-yeast biosorption systems were also introduced. In most cases, classic Langmiur model and Freundlich model, widely used to describe single metal biosorption system of equilibrium, fit the experimental data very well. Pseudo-second order equation is often employed to describe biosorption process by S. cerevisiae. Finally, futher researches in metal biosorpiton by S. cerevisiae were proposed.
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The traditional medical treasures of zhouyi and qianjin have much in common in the aspects of logic approach,recognition characteristics,values conception,theory construction,and category system,which demonstrate that the two doctrines are closely related both geographically and historically. Bearing the same cultural genes and value orientation,sharing similar constructions of logic approaches and recognition characteristics,the two doctrines contain a great deal of wisdom in recognition and practice.