Neuropatia periférica e sinais clínicos de síndrome coronariana aguda em pacientes com diabetes mellitus / Peripheral neuropaty and clinical signs of acute coronary syndrome in patients with diabetes mellitus / Neuropatía periférica y signos clínicos de síndrome coronario agudo en pacientes con diabetes mellitus

Objetivou-se avaliar o nível de neuropatia periférica em pacientes diabéticos com síndrome coronariana aguda e sua associação com a intensidade dos sinais clínicos. Estudo prospectivo, transversal e quantitativo. Os dados foram coletados de novembro de 2015 a fevereiro de 2016 em um hospital na cidade de São Paulo. Foram analisados os sinais clínicos apresentados pelos pacientes com síndrome coronariana aguda portadores de diabetes mellitus e o nível de neuropatia periférica pela Escala de Sintomas Neuropáticos. Foram avaliados 50 pacientes, apresentaram dor precordial em aperto em 33 (66%) participantes, além da sudorese e dispneia. Sintomas neuropáticos foram identificados em 33 (66%) pacientes, não observada associação entre o nível de neuropatia e a intensidade dos sinais clínicos da síndrome coronariana aguda. A avaliação clínica realizada pelo enfermeiro em pacientes diabéticos com síndrome coronariana aguda deve ser feita de forma rigorosa, principalmente nos pacientes que podem apresentar sinais clínicos atípicos dependendo do grau de neuropatia periférica (AU).

This study aimed to assess the severity of peripheral neuropathy in diabetic patients with acute coronary syndrome and its association with the severity of clinical signs. Prospective, cross-sectional and quantitative study. Data were collected from November 2015 to February 2016 in a hospital in the city of São Paulo. The clinical signs of diabetic patients with acute coronary syndrome were analyzed and the intensity of peripheral neuropathy was assessed using the Neuropathic Symptom Score (NSS). Fifty patients were assessed, and 33 (66%) participants had precordial catch syndrome, as well as sweating and dyspnea. Neuropathic symptoms were also identified in 33 (66%) patients, and there was no association between intensity of neuropathy and intensity of clinical signs of acute coronary syndrome. The clinical assessment of diabetic patients with acute coronary syndrome by nurses should be very careful, especially in patients with atypical clinical signs, depending onthe degree of peripheral neuropathy (AU).

El objetivo fue evaluar el nivel de la neuropatía periférica en los pacientes diabéticos con síndrome coronario agudo y su asociación con la gravedad de los signos clínicos. Un estudio prospectivo, transversal y cuantitativo. Los datos fueron recolectados a partir de noviembre 2015 a febrero 2016 en un hospital de Sao Paulo. Se analizaron los signos clínicos observados en pacientes con síndrome coronario agudo, diabetes mellitus y el nivel de los síntomas Neuropatía periférica Neuropatía Scale. Se analizaron 50 pacientes tenían dolor en el pecho en 33 (66%) participantes, así como la sudoración y la disnea. síntomas neuropáticos se identificaron en 33 (66%) pacientes, y no hay asociación entre neuropatía y el nivel de intensidad de los signos clínicos de síndrome coronario agudo. La evaluación clínica llevada a cabo por la enfermera en pacientes diabéticos con síndrome coronario agudo debe realizarse con precisión, en particular en pacientes que pueden tener signos clínicos atípicos en función del grado de la neuropatía periférica (AU).

Caracterización clinicoepidemiológica de pacientes con infarto agudo del miocardio / Clinical epidemiologic characterization of individuals with severe heart attack

Se realizó un estudio descriptivo, transversal y retrospectivo de 33 pacientes con diagnóstico de infarto agudo del miocardio, ingresados en la unidad de cuidados intensivos del Hospital Emilio Bárcenas Pier del municipio de II Frente de la provincia de Santiago de Cuba, durante el año comprendido de enero a diciembre del 2007. En la casuística se halló un predominio de esa cardiopatía en los ancianos con alto riesgo coronario y del dolor precordial como manifestación clínica. Solo fallecieron 3 de los integrantes de la serie, pero ninguno de los tratados con medicación trombolítica

A descriptive, cross-sectional and retrospective study of 33 patients with acute heart attack diagnosis, admitted in the intensive care unit of the Emilio Bárcenas Pier Hospital in the municipality of II Frente, Santiago de Cuba province was carried out during the year 2007, from January to December. In the case material a predominant heart condition was found in elderly with high coronary risk and precordial pain sensation as a clinical feature. From the case material only three of the integrants died, but none of them treated with thrombolytic drugs

Analysis on One Case of Percardial Pain Induced by Drug Combination of Omeprazole / 中国药房

OBJECTIVE:To analyze one case of pericardial pain induced by drug combination of omeprazole so as to provide reference for drug combination in the clinic. METHODS:A 79-year-old male patient was admitted because of stage Ⅲ hypertension,coronary heart disease,acute attack of chronic bronchitis in Dec. 2 of 2009. He was treated with omeprazole and pericardial pain was observed during treatment. ADR caused by omeprazole were put forward in the clinic. RESULTS & CONCLUSION: Omeprazole combined with other drugs can easily cause ADR for example,pericardial pain. The universality of ADR induced by drug combination of omeprazole should be further confirmed because of limited sample.

Freqüência de precordialgia em mulheres chagásicas e não-chagásicas / Frequency of precordialgia in chagasic and non-chagasic women

O objetivo do estudo foi comparar a freqüência de precordialgia em mulheres chagásicas com grupo de não-chagásicas. Realizou-se estudo retrospectivo, amostral, do tipo corte transversal, com mulheres (n = 647), de idade ³ 40 anos, chagásicas (n = 362) e controles (n = 285). Precordialgia foi definida por queixa de dor retroesternal relacionada ou não a esforço físico. As chagásicas foram classificadas nas formas indeterminada (n = 125), megas (n = 58) e cardíaca (n = 179). A idade (57,0 ± 11,3 vs 57,3 ± 10,4 anos) e porcentagem de brancas (75,8% vs 77,1%) foram similares entre chagásicas e controles, respectivamente. Precordialgia foi mais freqüente (p < 0,01) entre chagásicas (14,6%) que entre controles (5,6%), com maior prevalência na forma cardíaca (risco relativo = 2,41; variação: 1,38-4,23), fenômeno possivelmente relacionado com distúrbios de inervação autonômica cardíaca ou esofágica, ou da inflamação em território da microcirculação coronariana.

The aim of this study was to compare the frequency of precordialgia between chagasic and non-chagasic women. A cross-sectional study comprised 647 female aged > or = 40, chagasic (n = 362) and controls (n = 285) was done at a Brazilian university hospital. Chagasic were classified as cardiac (n = 179), megas (n = 58) or indeterminate (n = 125) clinical forms. Chest pain was ascertained by typical or atypical retrosternal pain. Age (57.0 +/- 11.3 vs 57.3 +/- 10.4 years), and percentage of white women (75.8% vs 77.1%) were similar between chagasic and controls, respectively. Chest pain was more prevalent (p < 0.01) among chagasic (14.6%) than controls (5.6%), mainly in the cardiac form (relative risk = 2.41; range: 1.38-4.23), a phenomenon possibly related to cardiac parasympathetic denervation and myocardial microvascular changes.