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1.
Chinese Journal of Perinatal Medicine ; (12): 778-782, 2021.
Article in Chinese | WPRIM | ID: wpr-911968

ABSTRACT

Monochorionic triplet and dichorionic triplet pregnancies result in a higher risk of complications than trichorionic triplet due to its monochorionic part, and often lead to adverse pregnancy outcomes. We discuss the impact of different fetal reduction numbers, object and surgical methods on the outcome of monochorionic triplet and dichorionic triplet pregnancies. Compared with expectant management, several common fetal reduction strategies can reduce the risk of premature birth, prolong gestational weeks, and increase fetal birth weight. Reduction of the fetus with a separate placenta does not avoid the complications of monochorionic twins, and reducing one of the monochorionic pairs might cause the death of the remaining fetus, thereby requiring skilled surgeons. So, reduction of the monochorionic pair was preferred. More study are needed to evaluate the reduction strategy of monochorionic triplet.

2.
Chinese Journal of Obstetrics and Gynecology ; (12): 268-273, 2015.
Article in Chinese | WPRIM | ID: wpr-475776

ABSTRACT

Objective To investigate and evaluate the pregnancy outcomes and fetal loss after fetal reduction of triplets to twins or singleton pregnancy. Methods 282 cases of triplets who received multi-fetal pregnancy reduction (MFPR) at Shandong Provincial Hospital affiliated to Shandong University were recruited from Sep 2001 to Mar 2014. According to the remaining fetal number after MFPR, 231 cases were opted to reduce to twins (twins group) while 51 cases were opted to singleton pregnancy (singleton group).The indication of the former group was fetal abnormalities under ultrasound or on patients′ demand; while the indication for the later group included dichorionic triamniotic (DCTA) triplets or patients′ aspiration. Potassium chloride was injected into the targeted fetal heart until cardiac standstill was obtained. The pregnancy outcomes, gestational age at delivery, birth weight of newborns of the two groups were recorded. Successful pregnancy was defined as take-home at least one baby. Results (1)The overall rate of successful pregnancy was 91.5%(258/282).There were 413 neonates in the twins group, including 4 neonatal deaths and 409 live babies, with the successful rate of 90.5%(209/231). There were 49 neonates in the singleton group, including 2 cases of fetal loss. Thus the successful rate was 96.1%(49/51). There was no difference of successful pregnancy rate between the two groups(P>0.05).(2)The mean gestational age at operation for the twins group and singleton group were(16.5±3.5)weeks and (14.2±2.0) weeks, respectively. Each group was divided into three periods,11-13+6 weeks, 14-16+6 weeks and≥17 weeks.In the twins group, the cases in each time period were129(55.8%,129/231), 50(21.6%,50/231)and 52(22.5%,52/231), respectively. While in the singleton group, the cases in each time period were 27(53%,27/51), 16(31%, 16/51)and 8(16%,8/51).There was no difference between the two groups at each time period(P>0.05). (3)The fetal loss rate in the twins group were 7%(9/129), 12%(6/50), 10%(5/52) at each time period, respectively. While for the singleton group they were 4%(1/27), 0(0/16)and 1/8, respectively. There was no significant difference between the two groups at each time period(P>0.05).(4)The mean birth weight of the twins group was lower than the singleton group [(2 555±447) g vs (3 084±550) g, respectively, P0.05).(5)The gestational age at delivery of the twins group was earlier than the singleton group [(36.2 ± 2.4) weeks vs(38.3 ± 2.2)weeks, respectively,P0.05].Conclusions Reduction to one fetus led to significantly better outcome than two fetuses, with no significant difference in fetal loss rate. It is better to advise patients with triplets reduce to singleton pregnancy.

3.
Rev. bras. ginecol. obstet ; 36(9): 393-397, 09/2014. tab
Article in English | LILACS | ID: lil-723268

ABSTRACT

PURPOSE: To evaluate the obstetric and perinatal outcomes evolution of triplet pregnancies. METHODS: A prospective observational study was conducted in triplet pregnancies delivered over 16 years in a tertiary obstetric center with differentiated perinatal support. Evaluation of demographic factors, obstetric complications, gestational age at delivery, mode of delivery, birth weight and immediate newborn outcome were done over a 16 years period. A global characterization of the sample was performed considering the listed parameters. Variables were categorized in three groups according to year of occurrence: 1996-2000, 2001-2006, 2007-2011, and all parameters were compared. RESULTS: Of the 33 triplets included, 72.7% resulted from induced pregnancies. All except one patient received prenatal corticosteroids and five received tocolytics. All women delivered prenatally and no significant differences were seen in the mean gestational age at delivery or birth weight towards time. There were three intrauterine fetal deaths. Neonatal immediate outcomes were not significantly different over the years. CONCLUSION: Despite remarkable progresses in perinatal and neonatal cares, no noticeable impact in triplet gestations' outcomes was seen, sustaining that triplets should be avoided due to their great risk of prematurity and neonatal morbidities, either by limiting the numbers of embryos transferred or by fetal reduction. .


OBJETIVO: Avaliar a evolução obstétrica e os resultados perinatais das gestações triplas. MÉTODOS: Um estudo observacional prospectivo foi realizado em gestações triplas durante 16 anos num centro obstétrico terciário com apoio perinatal diferenciado. Foram realizadas avaliações dos fatores demográficos, de complicações obstétricas, da idade gestacional ao parto, do tipo de parto, peso do recém-nascido e resultado neonatal imediato por um período de 16 anos. A caracterização global da amostra foi realizada considerando os parâmetros listados. As variáveis ​​foram divididas em três grupos de acordo com o ano de ocorrência: 1996-2000, 2001-2006, 2007-2011, e todos os parâmetros foram comparados. RESULTADOS: Das 33 gestações triplas incluídas, 72,7% resultaram de gravidezes induzidas. Exceto uma paciente, todas receberam corticosteroides pré-natal e cinco efetuaram tocolíticos. Todas as mulheres tiveram um parto pré-termo e não se observaram diferenças significativas na idade gestacional média ao parto nem no peso ao nascer ao longo do tempo. Houve três óbitos fetais. Os resultados neonatais imediatos não foram significativamente diferentes ao longo dos anos. CONCLUSÃO: Apesar dos avanços notáveis ​​em cuidados perinatais e neonatais, nenhum impacto perceptível nos resultados de gestações triplas foi verificado. Essas gestações devem ser evitadas devido ao grande risco de prematuridade e morbilidade dos recém-nascidos, tanto por limitação do número de embriões transferidos como por redução fetal. .


Subject(s)
Adult , Female , Humans , Infant, Newborn , Pregnancy , Pregnancy Outcome , Pregnancy, Triplet , Prospective Studies , Time Factors
4.
São Paulo; s.n; 2014. [145] p. ilus, tab, graf.
Thesis in Portuguese | LILACS | ID: lil-730769

ABSTRACT

O presente estudo tem como objetivo descrever a mortalidade perinatal em gestações trigemelares, e analisar os fatores preditores dos seguintes desfechos: número de crianças vivas no momento da alta hospitalar, nenhuma criança viva no momento da alta hospitalar (desfavorável) e pelo menos uma criança viva no momento da alta hospitalar (favorável). Realizado de forma retrospectiva, envolveu pacientes com gestações trigemelares que apresentavam três fetos vivos na primeira ultrassonografia realizada após 11 semanas, no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP), no período de 1998 a 2012. Foram incluídas 67 pacientes das quais 77,6% referiam concepção espontânea. Quanto à corionicidade, 49,2% eram tricoriônicas e 50,8% eram não tricoriônicas; 16,4% apresentavam antecedente clínico prévio à gestação e 49,2% eram nulíparas. Em relação às intercorrências, a incidência de complicações obstétricas e/ou clínicas na gestação foi de 52,2%, e de intercorrências fetais, 25,2%, dentre as quais: 13,4% mal formações, 7,5% sindrome da transfusão feto fetal (STFF), 5,9% óbito fetal (OF), 4,5% insuficiência placentária, 4,4% fetos unidos, 1,5% feto acárdico. A idade gestacional média do parto foi de 31,9 ± 3,1 semanas, dos quais 83,5% foram cesáreas. O peso médio dos recém-nascidos vivos de 1.683 ± 508 g. Em relação à discordância de peso ao nascer: 57% apresentaram até 20%, 23,2% entre 20 e 30% e 19,6% acima de 30%. A taxa de óbitos fetais foi de 31,7%o nascimentos (IC95%: 11,7 - 67,8) e a mortalidade perinatal 249%o nascimentos (IC95%: 189 - 317). O tempo médio de internação dos recém-nascidos, que foram de alta vivos, foi de 29,3 ± 24,7 dias. A predição dos desfechos foi investigada por meio de regressão logística "stepwise", e incluiu as seguintes variáveis: idade materna, paridade (nulípara ou um ou mais partos anteriores), antecedente clínico, idade gestacional do primeiro ultrassonografia no HCFMUSP, corionicidade (gestações...


The present study, involving triplet pregnancies, describes perinatal mortality and investigates predictors of the following outcomes: number of children alive, no child alive (unfavorable outcome) and at least one child alive (favorable outcome) at hospital discharge. It is a retrospective study involving triplet pregnancies with live fetuses at the first ultrasound scan, performed after 11 weeks of gestation, at the Department of Obstetrics and Gynecology, São Paulo University Medical School Hospital, between 1998 and 2012. Final sample included 67 women, 77.6% reported spontaneous conception. Regarding the chorionicity, 49.2% were trichorionic; 16.4% had a medical complication prior to pregnancy, and 49.2% were nulliparous. The incidence of obstetric and/or clinical complications during pregnancy was 52.2%, and fetal complications occurred in 25.2%, (13.4% of major fetal abnormalities, 7.5% twin-to-twin transfusion syndrome, 5.9% stillbirth, 4.5% placental insufficiency, 4.4% conjoined twins and 1.5% acardic twin). The average gestational age at delivery was 31.9 ± 3.1 weeks, and 83.5% were cesarean. The average birthweight was 1683 ± 508 g and birth weight discordance up to 20% occurred in 57% of the cases; 23,2% had 20 to 30% discordance and 19.6%, was greater than 30%. The rate of stillbirth was 31.7%o births (95%CI: 11.7 - 67.8) and the perinatal mortality was 249%o births (95%CI: 189 - 317). The average hospital stay was 29.3 ± 24.7 days amongst children that were discharged alive. Stepwise logistic regression analysis was used to investigate prediction according to: maternal age, parity (nuliparous/multiparous), prior clinical history, gestational age at the first ultrasound scan at HCFMUSP, pregnancy chorionicity (trichorionic/non trichorionic), occurrence of clinical and/or obstetric complications during pregnancy, occurrence of fetal complications and gestational age at delivery. Significance level was set at 0.05. The number of children alive at...


Subject(s)
Humans , Female , Pregnancy , Fetal Death/epidemiology , Perinatal Mortality , Pregnancy Complications , Pregnancy, Triplet , Prenatal Diagnosis , Risk Factors , Ultrasonography, Prenatal
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