ABSTRACT
Alzheimer∗ s disease (AD) is a typical central nervous degenerative disease characterized by progressive cognitive impairment and behavioral damage, which is associated with the major pathological manifestations of extracellular amyloid deposition, intracellular neurofibrillary tangles, and neuron loss. Mild cognitive impairment ( MCI) is a kind of cognitive impairment status between normal cognition and AD, which is linked with a high risk of converting into AD. Previous studies mostly establish the animal models with clinical AD characteristics for mechanism research, drug screening, and new drug development. In recent years, researchers have attempted to establish animal models with clinical MCI characteristics, trying to intervene ear-ly at MCI stage to effectively prevent the occurrence of AD. There are many types of AD experimental animal models, and the MCI model should be distinguished from the AD model. Based on the systematic introduction of the characteristics of AD and MCI, this study aims to preliminarily evaluate the commonly used AD and MCI experimental animal models, providing sug-gestions for the research of AD and MCI.