ABSTRACT
Chinese materia medica (CMM) is a multi-component system. In addition to the study on single-component druggability, the focus should be also on how to integrate the rules of single-component druggability to construct a research system of suitable multi-component druggability of CMM. According to the basic theory of CMM guidance, the druggability of CMM has been accumulated by long-term clinical practice experience, and the curative effect is affirmed. The most critical issue is how to determine the attribution and intermolecular interaction of the well-defined CMM component group and develop a component CMM. However, how to integrate the physicochemical and biological apparent properties of the multi-component based on the apparent physical and chemical properties of the single-component is the key to the study on druggability and preparation modification of CMM. Therefore, the druggability study of the single-component medicine and the study of the change rules of multi-component CMM druggability by using compatibility principle of CMM and modern supramolecular chemistry theory are needed to performed to study on the druggability of CMM. The combination of CMM druggability, preparations and chemical modifications can maximize the success rate of the development of new CMMs. The characteristic of the autonomous “Qi-xi” for CMM “imprinting template” of supramolecules has an important guiding role in druggability research of CMM both in theory and practice.