Clinical observation of Ranibizumab on retinopathy of prematurity with or without preretinal hemorrhage / 国际眼科杂志(Guoji Yanke Zazhi)

@#AIM: To compare the therapeutic effect of Ranibizumab on retinopathy of prematurity(ROP)with or without preretinal hemorrhage(PRH). <p>METHODS: From April 2017 to January 2018, a retrospective study was carried out on the diagnosed and treated ROP cases 66 eyes of 34 in the Affiliated Eye Hospital of Nanchang University. All the infants were divided into two groups according to PRH or not. All patients were treated with intravitreal Ranibizumab under tropical anesthesia. The infants were followed up, and the cure and retreatment rate between the two groups after initial treatment were compared. <p>RESULTS: After the initial treatment of intravitreal Ranibizumab, the cure rate was 65%(17)and 98%(39), and the retreatment rate was 35%(9)and 2%(1)in bleeding and non-bleeding group, respectively. 9 eyes with PRH needed retreatment; however, only 1 eye retreatment in the non-bleeding group. Notably, all the retreatment cases were cured by once more intravitreal Ranibizumab. The cure rate between two groups was statistically significant. <p>CONCLUSION: The curative effect with initial treatment of ROP with PRH was significantly lower than that without PRH. The retreatment cases were attenuated by repeated intravitreal Ranibizumab treatment.

A Case of Valsalva Retinopathy Associated with Straining at Stool / 영남의대학술지

The Valsalva maneuver is described as an expiratory effort against a closed glottis or airway. It leads to elevation of retinal venous pressure and may result in retinal hemorrhage. A fifty two-year-old man presented with an acute reduction of central visual acuity in his right eye which occurred after considerable straining at stool. Detailed past medical history revealed that he suffered from chronic constipation and hypertension. There were one disc sized subhyaloid hemorrhage and three small intraretinal hemorrhages around the fovea at the dilated fundus examination. After three months of follow-up without any treatment, the retinal hemorrhages resolved without any sequelae. Here we report a patient with sudden visual loss and retinal hemorrhage.

Treatment of Retinal Arterial Macroaneurysm

PURPOSE: To evaluate the visual prognosis of retinal arterial macroaneurysm with various treatment. METHODS: We did retrospective study in 16 patients(16 eyes) of retinal arterial macroaneurysm diagnosed at our hospital from March 1996 to January 2003. RESULTS: The range of patient's age was from 26 to 92 year-old, and 10 patients were female and 6 patients were male. In 6 eyes without treatment, spontaneous absorption of hemorrhage or edema occurred in 4 eyes. In 2 eyes with preretinal hemorrhage involving the macular area, vision was improved 2 lines or more as hemorrhage was subsided. Two eyes with Nd: YAG laser photodisruption obtained visual improvement of 4 lines or more. In 2 eyes misdiagnosed as CNV, argon laser photocoagulation was performed. In 6 eyes treated surgically with tPA injection or pars plana vitrectomy, 5 eyes showed visual improvement of 4 lines or more. CONCLUSIONS: Laser therapy or vitrectomy seems to be an effective method for the treatment of retinal arterial macroaneurysm involving the macular area.