ABSTRACT
We studied the healing course and histologic change of ablated rabbit cornea following excimer laser photorefractive keratectomy using three different corneal wound healing methods; pressure patch, T-lens, collagen shield. Nine rabbits(18 eyes) were divided into three different groups according to its treatment method. Corneal status including the corneal haze, conjunctival injection, discharge amount at postoperative 1st day, 2nd day and 3rd day were the same, irrespective to the treatment method and corneal wound healing rate show no significant differentces in all the groups. The histologic feature revealed irregular epithelial hyperplasia and keratacyte infiltration in the superficial stromal layer on postoperative 3rd day and 7th day. These reactions lessened at postoperative 1 month. The cornea treated with pressure patch group revealed more severe tissue reaction when compared with the other groups, T-lens and collagen shield. These results suggest that the corneal wounds produced by excimer laser can be managed by T-lens as an another alternative method of wound treatment.
Subject(s)
Collagen , Cornea , Hyperplasia , Lasers, Excimer , Photorefractive Keratectomy , Wound Healing , Wounds and InjuriesABSTRACT
We studied the effects of three different treating methods on corneal repithelization after PRK such as pressure patch, therapeutic contact lens and collagen shield. The degree of pain among three different treating groups showed same results without difference. The postoperative corneal wound healing rate in collagen shield group was slower than the other groups at first day. The corneal wound healing duration in therapeutic contact lens was faster than the other groups. Therefore we could obtained the results that therapeutic contact lens treated group is clinically excellent method for accelerating corneal wound healing after excimer laser photorefractive keratectomy.
Subject(s)
Collagen , Epithelium, Corneal , Lasers, Excimer , Photorefractive Keratectomy , Wound Healing , Wounds and InjuriesABSTRACT
This study was performed to investigate the corneal epithelial healing time and rate according to the method for promoting the reepithelization after myopic epikeratoplasty. A prospective study was conducted on 30 myopic epikeratoplasties which were divided into 3 groups according to the method for promoting the epithelial healing. The groups consisted of 10 eyes with pressure patches, 10 eyes with Acuvue(R) disposable contact lens (CL) and 10 eyes with SeeQuence(R) disposable CL. The cornea epithelial healing time were 3.4, 3.5 and 3.4 postoperative days for the pressure patch, Acuvue(R) CL and SeeQuence(R) CL groups, respectively. The corneal epithelial healing rates during postoperative 1, 2, and 3 days were 0.33, 0.78, and 0.44 mm2/hour for the pressure patch group; 0.24, 0.92 and 0.37 mm2/hour for the Acuvue(R) CL group; and 0.30, 0.79 and 0.38 mm2/hour for the SeeQuence(R) CL group. These results suggest that a disposable contact lens may not hinder epithelial healing compared with a pressure patch.
Subject(s)
Adult , Female , Humans , Male , Middle Aged , Bandages , Contact Lenses , Cornea/physiology , Corneal Transplantation , Epithelium/physiology , Myopia/physiopathology , Prospective Studies , Time Factors , Wound Healing/physiologyABSTRACT
To investigate the effect of disposable contact lenses (CL) on the corneal epithelial healing, a prospective study of 30 myopic epikeratoplasties which were divided into 3 groups according to the method for promoting the corneal epithelial healing was conducted. The groups are consisted of 10 eyes with pressure patch, 10 eyes with Acuvue(R) disposable CL and 10 eyes with SeeQuence(R) disposable CL. Corneal epithelial healing was completed in the pressure patch, Acuvue(R) CL and SeeQuence(R) CL group at 3.4, 3.5 and 3.4 postoperative days, respectively. Corneal epithelial healing rate during postoperative 1, 2 and 3 days are 0.33, O.78, and O.44mm2/hour in pressure patch group, O.24, O.92 and O.37mm2/hour in Acuvue(R) CL group, and O.30, O.79 and O.38mm2/hour in SeeQuence(R) CL group respectively. From the above results, it is concluded that there was no statistically significant difference of the corneal epithelial healing time and rate between the pressure patching and disposable bandage CL wearing after myopic epikeratoplasty.