ABSTRACT
In the WHO-EORTC (World Health Organization-European Organization for Research and Treatment of Cancer) classification, the primary cutaneous B-cell lymphomas were divided into 4 groups: primary cutaneous marginal zone B-cell lymphoma, primary cutaneous follicle center cell lymphoma, primary cutaneous diffuse large B-cell lymphoma, other, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCLBCL LT). PCLBCL LT is known to have more aggressive clinical behavior and a worse prognosis than the other groups of primary cutaneous B-cell lymphomas. We report here on a case of PCLBCL LT in a 55-year-old male who presented witha multiple erythematous nodules on the right leg. After chemotherapy, the skin lesions had almost cleared, but afterward the tumor was revealed to have metastasized to the brain during 1 year.
Subject(s)
Humans , Male , Middle Aged , B-Lymphocytes , Brain , Leg , Lymphoma , Lymphoma, B-Cell , Lymphoma, B-Cell, Marginal Zone , Neoplasm Metastasis , Prognosis , Skin , World Health OrganizationABSTRACT
Primary cutaneous diffuse large B-cell lymphoma of the leg is characterized by a diffuse non-epidermotropic infiltrate predominantly made up of large non-cleaved B-cells, with variable proportions of centroblast- and immunoblast-like cells. We report a case of a 90-year-old female, who presented with a solitary erythematous nodule and ulceration on the lower leg. Physical examination and staging work-up revealed no evidence of systemic involvement. After total excision and a split-thickness skin graft, the skin lesion was almost cleared. Furthermore, no other skin lesion was observed during a 1 year of follow up period.
Subject(s)
Aged, 80 and over , Female , Humans , B-Lymphocytes , Follow-Up Studies , Leg , Lymphoma, B-Cell , Physical Examination , Skin , Transplants , UlcerABSTRACT
We report herein a case of primary cutaneous diffuse large B-cell lymphoma with multiple skin lesions in a Korean woman. A 56-year-old woman presented with rapidly growing multiple sub-cutaneous nodules in her right flank and right upper arm. Microscopic examination of skin biopsy specimen showed diffuse infiltrates of large atypical lymphocytes with vesicular nuclei, prominent nucleoli and moderate degree of mitotic figures in deep dermis and subcutis. Immunophenotypic studies revealed the lymphoid infiltrates reacted with CD45, CD20 and bcl-2 protein, but none of the sections expressed CD3, bcl-6 protein and CD30. In physical examination and staging work-up, we could not find any other extracutaneous or systemic involvement. She was treated with 2 cycles of high-dose multiagent chemotherapy with the Vanderbilt and the BEAM regimen combined with the autologous peripheral blood stem cell transplantation. Until now, 10 months after termination of treatment, she has shown improvement of all skin lesions and no development of extracutaneous disease.
Subject(s)
Female , Humans , Middle Aged , Arm , B-Lymphocytes , Biopsy , Dermis , Drug Therapy , Lymphocytes , Lymphoma, B-Cell , Peripheral Blood Stem Cell Transplantation , Physical Examination , SkinABSTRACT
Primary cutaneous diffuse large B-cell lymphomas are characterized by a non-epidermotropic monotonous infiltrate of large follicular center cells with various proportions of centroblasts, large centrocytes, multilobated cells or immunoblasts without extracutaneous manifestations. We report a case of a 61-year-old man, who presented with several, annular plaques on the trunk. The clinicopathologic features and immunohistochemical profiles were diagnostic of primary cutaneous diffuse large B-cell lymphoma.