Primary intraosseous carcinoma of the mandible: A case report

Objective@#To present a rare case of primary intraosseous carcinoma arising from the mandible and to discuss the ensuing course and the management of the patient. @*Methods@#Design: Case Report. Setting: General Tertiary Government Training Hospital. Patient: One. @*Result@#A 56-year-old man consulted for a right mandibular mass of 4 months that started as a small bony swelling which gradually increased to its present size of 8 x 6 cm. Incisional biopsy revealed invasive squamous cell carcinoma and the patient underwent segmental mandibulectomy and bilateral selective neck dissection (levels 1 to 3). Final histopathologic findings revealed squamous cell carcinoma. @*Conclusion@#Primary intraosseous carcinoma of the mandible was diagnosed since there was no overlying mucosal ulceration, other types of odontogenic carcinoma were ruled out, and no other distant primary tumor was noted from the time of examination until six months post-treatment.

Verrucous carcinoma arising from a previous cystic lesion: a case report / 대한악안면성형재건외과학회지

BACKGROUND: Verrucous carcinoma (VC) accounts for 1–10% of cases of squamous cell carcinoma (SCC) in the oral cavity, and 75% of VC occur in the oral cavity. Only 3% of primary intraosseous squamous cell carcinomas (PIOSCC), which means SCC occurring primarily in the bone, are VC. Verrucous carcinoma arising from odontogenic cysts (OC) is very rare, with only seven cases reported to date. CASE PRESENTATION: This study reported a case of a patient who underwent partial maxillectomy and neck dissection for VC that occurred in the right anterior maxilla. The patient was admitted to the emergency department at our institution 8 years ago and showed cystic lesions in the anterior maxilla on facial computed tomography (CT) images. Treatment through other departments including assessment of laceration in the mental region and only suture was performed. This report highlights a very rare case of VC in the right anterior maxilla arising from a previous cystic lesion. CONCLUSIONS: Since PIOSCC can arise from OC, appropriate treatment of intraosseous cysts and regular radiologic evaluation are necesssary. Surgical exicision of the primary lesion without neck dissection can lead to good prognosis for patients with primary intraosseous verrucous carcinoma.

Carcinoma escamocelular intraóseo primario mandibular: reporte de caso / Primary intraosseous squamous cell carcinoma of the mandible: case report / Carcinoma mandibular intra-ósseio primário de células escamosas: relato do caso

El carcinoma escamocelular intraóseo primario mandibular se encuentra, de acuerdo con la clasificación de la Organización Mundial de la Salud, dentro de los carcinomas odontogénicos. Se trata de una neoplasia poco común, con una relación hombre:mujer de 3,5:1 y una mayor frecuencia de presentación entre la quinta y la sexta década de vida. Su localización más común es en la región posteroinferior mandibular, siendo localmente agresivo, con metástasis a ganglios linfáticos regionales. Debido a que su comportamiento es intraóseo y a que no presenta lesiones iniciales intraorales, su diagnóstico clínico es difícil, durando largos periodos sin que se sospeche su presencia. Confirmar su diagnóstico requiere de un estudio anatomopatológico que detecte la presencia de células epiteliales carcinomatosas intraóseas. Imagenológicamente se evidencia como una lesión quística atípica, mal definida en la mayoría de los casos, radiolúcida y con osteolisis. El tratamiento de elección, con fines curativos, es la realización de una exéresis con amplios márgenes de seguridad oncológica y una posterior cirugía reconstructiva. Se presenta en este artículo el caso de un paciente de 31 años de edad con un carcinoma escamocelular intraóseo primario de la mandíbula tipo sólido, al que se le realizó una resección mandibular derecha en bloque, seguida de cirugías reconstructivas hasta obtener un adecuado resultado funcional y estético...

The primary intraosseous squamous cell carcinoma of the mandible is classified by the World Health Organization within the odontogenic carcinomas. It is a rare disease. Epidemiologically the male: female ratio is 3,5:1. The highest incidence is in the fifth and sixth decades of life. The most affected area is the posteroinferior mandibular region. It is a locally aggressive tumor that metastasizes to regional lymph nodes. The clinical diagnosis is difficult, because their behavior is intraosseous so it can last long periods of time before the diagnosis is made. It requires a pathological study which detects the presence of intraoseus carcinomatous epithelial cells. Imaging shows a radiolucent lesion with osteolysis in the form of atypical cystic lesions poorly defined in most cases. The treatment of choice for curative purposes is to provide an excision with wide safety margins and subsequent reconstructive surgery. We present a 31 years old patient with a primary mandibular intraosseous squamous cell carcinoma (solid type), whose treatment consisted of an en bloc resection and right mandibular reconstructive surgeries to obtain an adequate functional and aesthetic result...

O carcinoma de preliminar intrabony escamocelular a mandibular está, no acordo com a classificação da organização World-wide da saúde, dentro dos carcinomas dos odontogénicos. Neoplasia é um pouco comum, com um homem da relação: mulher de 3,5:1 e uma freqüência mais grande da apresentação entre a quinta e sexta década da vida. Sua posição mais comum está na região do posteroinferior a mandibular, sendo localmente aggressive, com o metástasis ao ganglia lymphatic regional. Porque seu comportamento é intrabony e àquele não se apresentar/exposição os ferimentos iniciais intraoral, seu diagnóstico clínico é períodos longos difíceis, durando sem sua presença é suspeitado. Confirmar seu diagnóstico requer de um estudo do anatomopatológico que detecte a presença de pilhas epithelial dos carcinomatosas intrabony. Imagenológicamente é demonstrado como um ferimento atypical do quística, bad definido em a maioria dos casos, radiolúcida e com o osteolisis no formulário do L. O tratamento da eleição, com alvos dos curativos, é a realização de um exéresis com margens de segurança amplas do oncológica e uma cirurgia mais atrasada do reconstructiva. O exemplo de um paciente de 31 anos de idade com um carcinoma aparece neste artigo de preliminar intrabony escamocelular do tipo contínuo da maxila, a que um resección lhe foi feito à direita mandibular no bloco, seguido de cirurgias dos reconstructivas até obter um resultado funcional e aesthetic apropriado...

Primary intraosseous carcinoma on mandible: A case report

Primary intraosseous carcinoma (PIOC) is a rare odontogenic carcinoma defined as a squamous cell carcinoma arising within a jaw having no initial connection with the oral mucosa, and probably developing from residues of the odontogenic epithelium. PIOC appears more common in male than female, especially at posterior portion of the mandible. Radiographic features of PIOC show irregular patterns of bone destruction with ill defined margins. It could be sometimes misdiagnosed as the cyst or benign tumor because it shows well defined margins. If it couldn't be done appropriate treatment initially, PIOC shows extremely aggressive involvement, extensive local destruction and spreads to the overlying soft tissue. Therefore accurate diagnosis in early state is necessary. The diagnosis criteria proposed for PIOC are : (1) absence of ulcer formation, except when caused by other factors, (2) histologic evidence of squamous cell carcinoma without a cystic component or other odontogenic tumor cell, and (3) absence of another primary tumor on chest radiograph obtained at the time of diagnosis and during a follow-up period of more than 6 month(Suei et al., 1994).

Squamous Cell Carcinoma of the Maxilla Originated in Odontogenic Cyst: A Case Report

Primary intraosseous carcinoma(PIOC) is defined as a squamous cell carcinoma arising within the jaw, having no initial connection with the oral mucosa. The squamous cell carcinoma within the bone can be presumably developed from residues of the odontogenic epithelium, therefore, it is seen in the jaw only. Metastatic carcinoma from another primary site should be excluded in the diagnosis of Primary Intraosseous Carcinoma. This is a case of 62-year-old man, who initially diagnosed as odontogenic cyst on maxilla, but its pathologic examination was diagnosed as squamous cell carcinoma with odontogenic cyst. We treated this patient with partial maxillectomy, modified radical neck dissection(mRND), and postoperative radiation therapy.