ABSTRACT
Antecedentes: Los angiosarcomas son infrecuentes y corresponden a menos del 1 por ciento de tumores de tejidos blandos, pueden presentarse en cualquier localización fundamentalmente en la piel. El angiosarcoma primario uterino fue por primera vez reportado en 1902 por Silberberg con informes ulteriores esporádicos que suman un total de 33 casos incluyendo el presente. Objetivo: Exponer un caso diagnosticado en el Departamento de Patología de la Universidad Industrial de Santander (Bucaramanga-Colombia), y revisar la literatura de los casos previamente descritos. Caso clínico: Paciente de 25 años, con 2 años de evolución de menometrorragias y dolor pélvico crónico. Se realiza ablación endometrial encontrándose tumor maligno de endometrio pobremente diferenciado, infiltrante, el cual no es posible categorizar. Se efectúa una histerectomía ampliada, salpingooforectomía bilateral, linfadenectomía pélvica y omentectomía. El examen microscópico reveló lesión tumoral pobremente diferenciada compatible con un angiosarcoma uterino de alto grado.
Background: Angiosarcomas are rare and account for less than 1 percent of soft tissue tumors can occur at any location primarily in the skin. The primary uterine angiosarcoma was first reported in 1902 by Silberberg with sporadic subsequent reports, with a total of 33 cases including the present. Objective: To present a case diagnosed in the Department of Pathology, Universidad Industrial de Santander (Bucaramanga, Colombia) and review the literature of the cases previously described. Case report: A 25 years old woman, with 2 years of chronic pelvic pain and menometrorrhagia. Endometrial ablation is performed and an endometrial malignancy was found, poorly differentiated and infiltrating, which is not possible to categorize. It makes an extended hysterectomy, bilateral salpingo-oophorectomy, pelvic lymphadenectomy, and omentectomy. Microscopic examination revealed poorly differentiated tumor, compatible with a high-grade uterine angiosarcoma.
Subject(s)
Humans , Female , Adult , Hemangiosarcoma/diagnosis , Hemangiosarcoma/pathology , Uterine Neoplasms/diagnosis , Uterine Neoplasms/pathology , Hemangiosarcoma/surgery , Immunohistochemistry , Uterine Neoplasms/surgeryABSTRACT
Angiosarcoma is defined as a malignant tumor of the endothelial cells present in blood vessels and represents less than 1% of all soft tissue sarcomas. Primary uterine angiosarcomas are particularly rare, and tend to have poor prognosis mostly related to the aggressive nature and the metastatic potential of these tumors. They present most commonly with vaginal bleeding or with weight loss and a pelvic mass. Although postoperative radiation and combination chemotherapy are options being utilized, the results have only shown limited success. We report a case of primary uterine angiosarcoma with a brief review of literature.